The DOI matches its Crossref record.
Frequency of glucocorticoid resistance and dependency in Crohn's disease.
Open accessAbstract
The outcome of the first steroid treatment course was prospectively studied in a regional cohort of 196 patients with Crohn's disease diagnosed 1979-1987. The immediate outcome after 30 days, and the prolonged outcome 30 days after treatment had stopped, are described. In all 109 patients treatment was analysed. Complete remission was obtained in 48%, partial remission in 32%, and no response in 20% within 30 days of treatment. Among primary responders (complete and partial remission), 55% remained in prolonged response after treatment had finished, while 45% relapsed or could not be withdrawn from treatment within one year. Localisation of disease, age, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.
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Cited by
Faubion, W. A., Loftus, E. V., Harmsen, W. S., Zinsmeister, A. R., & Sandborn, W. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.26279 · Cited by 1,144
The Natural History of Adult Crohn's Disease in Population-Based Cohorts
Peyrin-Biroulet, L., Loftus, E. V., Colombel, J.-F., & Sandborn, W. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.579 · Cited by 1,047
Vind, I., Riis, L., Jess, T., Knudsen, E., Pedersen, N., Elkjær, M., Andersen, I. B., Wewer, V., Nørregaard, P., Moesgaard, F., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00552.x · Cited by 532
Self-citationMutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
Abreu, M. T., Taylor, K. D., Lin, Y.-C., Hang, T., Gaiennie, J., Landers, C. J., Vasiliauskas, E. A., Kam, L. Y., Rojany, M., Papadakis, K. A., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.35393 · Cited by 428
Lichtenstein, G. R., Abreu, M. T., Cohen, R., & Tremaine, W. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.048 · Cited by 417
Metadata
- Authors
- Munkholm, P., Langholz, E., Davidsen, M., & Binder, V
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1994-03-01
- Volume
- 35
- Issue
- 3
- Pages
- 360-362
- ISSN
- 0017-5749 (ISSN-L)
- OpenAlex
- W2154117979
- Cited by
- 654
- References
- 0
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Frequency of glucocorticoid resistance and dependency in Crohn's disease. https://app.cochat.ai/papers/10.1136/gut.35.3.360
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- Munkholm, P., Langholz, E., Davidsen, M., & Binder, V. (1994). Frequency of glucocorticoid resistance and dependency in Crohn's disease. Gut. https://doi.org/10.1136/gut.35.3.360
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
