The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.
Open accessAbstract
Little is known of the function of the T cells in the inflammatory infiltrate in Helicobacter pylori associated gastritis. This study thus measured T cell in vivo activation by enumerating the frequency of interferon gamma (IFN gamma) and interleukin 4 (IL 4) secreting cells isolated from the gastric antral mucosa in patients with or without gastritis and in H pylori positive and negative gastritis. Fifty four samples were examined for cytokine secretion. Four antral biopsy specimens from each patient (n = 51) were taken during diagnostic endoscopy. One was used to estimate histological gastritis and the presence of H pylori, and three of the samples were used to isolate T cells by enzymatic digestion. IFN gamma and IL 4 secreting cells were enumerated by ELISPOT. Thirty four samples had gastritis and 79% of those were H pylori positive. None of the samples from non-inflamed mucosa had H pylori. The numbers of IFN gamma secreting cells per 10(5) T cells were higher in gastritis than in normal mucosa (145 v 20 IFN gamma spots, p < 0.01), and higher in H pylori negative than H pylori positive gastritis (371 v 110 IFN gamma spots, p < 0.05). The frequencies of IL 4 secreting cells did not differ between gastritis and non-inflamed mucosa. In conclusion, there is an increase in IFN gamma secreting cells but not in IL 4 secreting cells in H pylori positive and negative gastritis. It is not known if this TH1 type reaction has a pathogenetic or protective role.
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Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
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Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype
Bamford, K. B., Fan, X., Crowe, S. E., Leary, J. F., Gourley, W. K., Luthra, G. K., Brooks, E. G., Graham, D. Y., Reyes, V. E., & Ernst, P. B. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70531-1 · Cited by 573
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Wilson, K. T., & Crabtree, J. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.008 · Cited by 278
Metadata
- Authors
- Karttunen, R., Karttunen, T., Ekre, H. P., & MacDonald, T. T.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1995-03
- Volume
- 36
- Issue
- 3
- Pages
- 341-345
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2028247108
- Cited by
- 254
- References
- 14
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Karttunen, R., Karttunen, T., Ekre, H. P., & MacDonald, T. T. (1995). Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis. Gut. https://doi.org/10.1136/gut.36.3.341
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