Effect of bran particle size on gastric emptying and small bowel transit in humans: a scintigraphic study.
Open accessAbstract
Bran is an effective treatment for constipation but its use is often limited by heartburn and bloating. This study examined the effect of fine and coarse bran (15 g) on the gastric emptying and small bowel transit of a 325 kcal rice test meal. Twelve healthy volunteers underwent a three way cross over study, ingesting the technetium-99m labelled rice meal with or without 15 g of indium-111m labelled fine or coarse bran, in random order. Serial scintigraphic images were obtained to define gastric emptying and colonic arrival of label. Compared with control values (99 (9) minutes) (mean (SEM)), the time to 50% gastric emptying was significantly delayed by coarse but not fine bran, being 121 (6) and 104 (9) minutes respectively, p < 0.05, n = 12. Fundal emptying was unchanged but both brans seemed to increase the proportion of isotope in the antrum at 90 minutes. Small bowel transit was slightly faster with both bran types but in this study the difference was not significant. Both the bran and rice labels moved down the gut without significant separation. Fine bran causes less disturbance of gastric physiology than coarse bran.
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Gastric emptying is enhanced with decreased fat, fiber, and increased liquids.
“Other investigations indicate that gastric emptying is enhanced with decreased fat (Frost et al. 2003), fiber (Vincent et al. 1995), and increased liquids (Hellström et al. 2006).”
From Males and females exhibit similar muscle glycogen recovery with varied recovery food sources (2020) · cites this paper as Vincent et al. 1995
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- Authors
- Vincent, R., Roberts, A., Frier, M., Perkins, A. C., MacDonald, I. A., & Spiller, R. C.
- Affiliations
- Queen's Medical Centre (GB)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1995-08
- Volume
- 37
- Issue
- 2
- Pages
- 216-219
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1382721
- OpenAlex
- W2004699839
- Cited by
- 72
- References
- 21
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 3
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- bran particle size, gastric emptying, small intestinal transit, constipation treatment, technetium-99m scintigraphy, colonic transit
- MeSH terms
- Adult, Colon, Dietary Fiber, Female, Gastric Emptying, Gastrointestinal Transit, Humans, Indium Radioisotopes, Intestine, Small, Male, Particle Size, Radionuclide Imaging, Oryza, Stomach, Technetium, Triticum
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