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Cited by 393Sepsis Diagnosis and TreatmentAbdominal Surgery and ComplicationsAbdominal vascular conditions and treatments

The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.

Microbiology of bacterial translocation in humans

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O’Boyle, C J, MacFie, J, Mitchell, C J, Johnstone, D, Sagar, P M, Sedman, P C·1998·Gut
DOI 10.1136/gut.42.1.29PMC PMC1726947
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Abstract

BACKGROUND: Gut translocation of bacteria has been shown in both animal and human studies. Evidence from animal studies that links bacteria translocation to the development of postoperative sepsis and multiple organ failure has yet to be confirmed in humans. AIMS: To examine the spectrum of bacteria involved in translocation in surgical patients undergoing laparotomy and to determine the relation between nodal migration of bacteria and the development of postoperative septic complications. METHODS: Mesenteric lymph nodes (MLN), serosal scrapings, and peripheral blood from 448 surgical patients undergoing laparotomy were analysed using standard microbiological techniques. RESULTS: Bacterial translocation was identified in 69 patients (15.4%). The most common organism identified was Escherichia coli (54%). Both enteric bacteria, typical of indigenous intestinal flora, and non-enteric bacteria were isolated. Postoperative septic complications developed in 104 patients (23%). Enteric organisms were responsible in 74% of patients. Forty one per cent of patients who had evidence of bacterial translocation developed sepsis compared with 14% in whom no organisms were cultured (p < 0.001). Septic morbidity was more frequent when a greater diversity of bacteria resided within the MLN, but this was not statistically significant. CONCLUSION: Bacterial translocation is associated with a significant increase in the development of postoperative sepsis in surgical patients. The organisms responsible for septic morbidity are similar in spectrum to those observed in the mesenteric lymph nodes. These data strongly support the gut origin hypothesis of sepsis in humans.

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Research works printed but not linked: 4

  1. Guzman-Stein, 1987, Intestinal handling facilitates enteric bacterial translocation., Surg Forum, 38, 75
  2. Berg, 1982, Bacterial translocation from the gastrointestinal tract of thymectomized mice., Curr Microbiol, 7, 169, 10.1007/BF01568970 · DOI
  3. Penn, 1985, Leukaemia promotes the translocation of indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs., Microecology Therapy, 15, 85
  4. 10.1136/gut.38.Suppl_1.A68 · DOI

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Metadata

Authors
O’Boyle, C. J., MacFie, J., Mitchell, C. J., Johnstone, D., Sagar, P. M., & Sedman, P. C.
Affiliations
  • Combined Gastroenterology Service, Scarborough Hospital, Scalby Road, Scarborough, North Yorkshire, UK
  • Scarborough General Hospital (GB)
Corresponding author
MacFie, J
ORCID
Venue
Gut
Publisher
BMJ
Published
1998-01-01
Volume
42
Issue
1
Pages
29-35
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gut.42.1.29
PMC
PMC1726947
OpenAlex
W2116727622
Cited by
393
References
37
Citations by year
2026: 3 · 2025: 6 · 2024: 18 · 2023: 6 · 2022: 12 · 2021: 21 · 2020: 12 · 2019: 14 · 2018: 11 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 17 · 2013: 16 · 2012: 9
FWCI
13.31
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Abdominal Surgery and Complications
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
Keywords
bacterial translocation, postoperative sepsis, mesenteric lymph nodes, Escherichia coli, laparotomy, surgical patients, bacterial diversity, enteric bacteria, multiple organ failure
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Infections, Bacteriological Techniques, Escherichia coli, Female, Humans, Laparotomy, Lymph Nodes, Male, Middle Aged, Postoperative Complications, Prevalence, Bacterial Translocation

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