The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Microbiology of bacterial translocation in humans
Open accessAbstract
BACKGROUND: Gut translocation of bacteria has been shown in both animal and human studies. Evidence from animal studies that links bacteria translocation to the development of postoperative sepsis and multiple organ failure has yet to be confirmed in humans. AIMS: To examine the spectrum of bacteria involved in translocation in surgical patients undergoing laparotomy and to determine the relation between nodal migration of bacteria and the development of postoperative septic complications. METHODS: Mesenteric lymph nodes (MLN), serosal scrapings, and peripheral blood from 448 surgical patients undergoing laparotomy were analysed using standard microbiological techniques. RESULTS: Bacterial translocation was identified in 69 patients (15.4%). The most common organism identified was Escherichia coli (54%). Both enteric bacteria, typical of indigenous intestinal flora, and non-enteric bacteria were isolated. Postoperative septic complications developed in 104 patients (23%). Enteric organisms were responsible in 74% of patients. Forty one per cent of patients who had evidence of bacterial translocation developed sepsis compared with 14% in whom no organisms were cultured (p < 0.001). Septic morbidity was more frequent when a greater diversity of bacteria resided within the MLN, but this was not statistically significant. CONCLUSION: Bacterial translocation is associated with a significant increase in the development of postoperative sepsis in surgical patients. The organisms responsible for septic morbidity are similar in spectrum to those observed in the mesenteric lymph nodes. These data strongly support the gut origin hypothesis of sepsis in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Substantial clinical and experimental evidence supports the gut-lymph hypothesis.”
From The microbiome and critical illness (2016) · cites this paper as [10]
In the citing paper
“detection of bacteria in mesenteric lymph is predictive of subsequent sepsis and infectious complications.”
From The microbiome and critical illness (2016) · cites this paper as [10]
In the citing paper
“In clinical studies of critically ill high-risk surgical patients and in animal studies of shock, bacteria have been cultured from the mesenteric lymph nodes.”
From The microbiome and critical illness (2016) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
Manual for the identification of medical bacteria.
Cowan, S. T., & Steel, K. (1965) · Cambridge University Press eBooks · Cited by 4,823
Cowan and Steel's Manual for the Identification of Medical Bacteria
Cowan, S. T., Feltham, R. K. A., Steel, K., & Barrow, G. I. (1993) · Cambridge University Press eBooks · doi:10.1017/cbo9780511527104 · Cited by 3,244
Berg, R. D., & Garlington, A. W. (1979) · Infection and Immunity · doi:10.1128/iai.23.2.403-411.1979 · Cited by 845
Wolf, S. E. (1999) · CRC Press eBooks · doi:10.1201/9781498713979-15 · Cited by 821
Total parenteral nutrition promotes bacterial translocation from the gut
Alverdy, J. C., Aoys, E., & Moss, G. S. (1989) · Journal of Critical Care · doi:10.1016/0883-9441(89)90136-6 · Cited by 737
The gastrointestinal tract. The “undrained abscess” of multiple organ failure
Marshall, J. C., Christou, N. V., & Meakins, J. L. (1993) · Annals of Surgery · doi:10.1097/00000658-199308000-00001 · Cited by 707
Bacterial translocation from the gastrointestinal tract
Berg, R. D. (1995) · Trends in Microbiology · doi:10.1016/s0966-842x(00)88906-4 · Cited by 443
The Process of Microbial Translocation
ALEXANDER, J. W., Boyce, S. T., Babcock, G. F., Gianotti, L. V., Peck, M. D., Dunn, D. L., Pyles, T., Childress, C. P., & ASH, S. K. (1990) · Annals of Surgery · doi:10.1097/00000658-199010000-00012 · Cited by 436
Human intestinal microflora in health and disease
(1985) · Food and Chemical Toxicology · doi:10.1016/0278-6915(85)90079-1 · Cited by 429
The prevalence of gut translocation in humans
Sedman, P. C., Macfle, J., Sagar, P., Mitchell, C. J., May, J., Mancey-Jones, B., & Johnstone, D. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90110-4 · Cited by 362
Self-citationFUNGÆMIA AND FUNGURIA AFTER ORAL ADMINISTRATION OF CANDIDA ALBICANS
Kŕause, W., Matheis, H., & Wulf, K. (1969) · The Lancet · doi:10.1016/s0140-6736(69)91534-7 · Cited by 351
Michetti, P., Mahan, M. J., Slauch, J. M., Mekalanos, J. J., & Neutra, M. R. (1992) · Infection and Immunity · doi:10.1128/iai.60.5.1786-1792.1992 · Cited by 351
Small Intestine Bacterial Overgrowth
King, C. E., & Toskes, P. P. (1979) · Gastroenterology · doi:10.1016/s0016-5085(79)91337-4 · Cited by 339
Obstructive jaundice promotes bacterial translocation from the gut
Deitch, E. A., Sittig, K. M., Ma, L., Berg, R. D., & Specian, R. D. (1990) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)80610-5 · Cited by 300
Bacterial Translocation and Gram-Negative Bacteremia in Patients with Hematological Malignancies
Tancrède, C., & Andremont, A. O. (1985) · The Journal of Infectious Diseases · doi:10.1093/infdis/152.1.99 · Cited by 291
The human intestinal microflora
Simon, G. L., & Gorbach, S. L. (1986) · Digestive Diseases and Sciences · doi:10.1007/bf01295996 · Cited by 286
Simple Intestinal Obstruction Causes Bacterial Translocation in Man
Deitch, E. A. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410060065013 · Cited by 279
Steffen, E. K., Berg, R. D., & Deitch, E. A. (1988) · Journal of Infectious Diseases · doi:10.1093/infdis/157.5.1032 · Cited by 234
Ambrose, N. S., Johnson, M., Burdon, D. W., & Keighley, M. R. B. (1984) · British journal of surgery · doi:10.1002/bjs.1800710821 · Cited by 195
Food without fiber promotes bacterial translocation from the gut.
Spaeth, G., Berg, R. D., Specian, R. D., & Deitch, E. A. (1990) · PubMed · Cited by 160
Berg, R. D. (1983) · Current Microbiology · doi:10.1007/bf01577729 · Cited by 143
Function of Various Intestinal Bacteria in Converting Germfree Mice to the Normal State
Freter, R., & Abrams, G. D. (1972) · Infection and Immunity · doi:10.1128/iai.6.2.119-126.1972 · Cited by 138
Total parenteral nutrition, bacterial translocation, and host immune function
Shou, J., Lappin, J. A., Minnard, E. A., & Daly, J. M. (1994) · The American Journal of Surgery · doi:10.1016/0002-9610(94)90065-5 · Cited by 124
van der Waaij, D., Vries, J. M. B.-D., & der Wees, J. E. C. L.-V. (1972) · Journal of Hygiene · doi:10.1017/s0022172400022385 · Cited by 124
Intestinal obstruction promotes gut translocation of bacteria
Sagar, P. M., Macfie, J. M., Sedman, P. C., May, J. P., Mancey-Jones, B., & Johnstone, D. J. (1995) · Diseases of the Colon & Rectum · doi:10.1007/bf02054126 · Cited by 123
Self-citationAlexander, J. W. (1990) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719001400505 · Cited by 117
BACTERIAL TRANSLOCATION OCCURS IN HUMANS AFTER TRAUMATIC INJURY
BRATHWAITE, C. E. M., Ross, S. E., Nagele, R., Mure, A. J., O’Malley, K. F., & Garcia-Perez, F. A. (1993) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199304000-00017 · Cited by 106
Translocation of Indigenous Bacteria from the Intestinal Tract
Berg, R. D. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-341280-5.50021-5 · Cited by 99
Apter, F. M., Lencer, W. I., Finkelstein, R. A., Mekalanos, J. J., & Neutra, M. R. (1993) · Infection and Immunity · doi:10.1128/iai.61.12.5271-5278.1993 · Cited by 88
Yao, Y.-M., Bahrami, S., Leichtfried, G., Redl, H. R., & Schlag, G. (1995) · Annals of Surgery · doi:10.1097/00000658-199504000-00011 · Cited by 85
Clinical trials of selective decontamination of the digestive tract
Reidy, J., & Ramsay, G. (1990) · Critical Care Medicine · doi:10.1097/00003246-199012000-00028 · Cited by 64
Small Intestinal Bacterial Overgrowth
Bushyhead, D. W., & Quigley, E. M. M. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.02.008 · Cited by 48
Bacterial translocation from the gastrointestinal tracts of thymectomized mice
Owens, W. E., & Berg, R. D. (1982) · Current Microbiology · doi:10.1007/bf01568970 · Cited by 38
Bacterial Translocation in Patients with Colorectal Cancer
Vincent, P., Colombel, J. F., Lescut, D., Fournier, L., Savage, C., Cortot, A., Quandalle, P. A., Vankemmel, M., & Leclerc, H. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/158.6.1395 · Cited by 38
Small Intestinal Bacterial Overgrowth
Maneerattanaporn, M., & Chey, W. D. (2010) · doi:10.1002/9781444328417.ch35 · Cited by 28
Flagged first, then by citations
1 of the 37 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Guzman-Stein, 1987, Intestinal handling facilitates enteric bacterial translocation., Surg Forum, 38, 75
- Berg, 1982, Bacterial translocation from the gastrointestinal tract of thymectomized mice., Curr Microbiol, 7, 169, 10.1007/BF01568970 · DOI
- Penn, 1985, Leukaemia promotes the translocation of indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs., Microecology Therapy, 15, 85
- 10.1136/gut.38.Suppl_1.A68 · DOI
Cited by
Sorted by citations
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927
Interactions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,683
Dickson, R. P., Singer, B. H., Newstead, M. W., Falkowski, N. R., Erb-Downward, J. R., Standiford, T. J., & Huffnagle, G. B. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.113 · Cited by 724
Liver — guardian, modifier and target of sepsis
Strnad, P., Tacke, F., Koch, A., & Trautwein, C. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.168 · Cited by 692
Metadata
- Authors
- O’Boyle, C. J., MacFie, J., Mitchell, C. J., Johnstone, D., Sagar, P. M., & Sedman, P. C.
- Affiliations
- Combined Gastroenterology Service, Scarborough Hospital, Scalby Road, Scarborough, North Yorkshire, UK
- Scarborough General Hospital (GB)
- Corresponding author
- MacFie, J
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1998-01-01
- Volume
- 42
- Issue
- 1
- Pages
- 29-35
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1726947
- OpenAlex
- W2116727622
- Cited by
- 393
- References
- 37
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 18 · 2023: 6 · 2022: 12 · 2021: 21 · 2020: 12 · 2019: 14 · 2018: 11 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 17 · 2013: 16 · 2012: 9
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Abdominal Surgery and Complications
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- bacterial translocation, postoperative sepsis, mesenteric lymph nodes, Escherichia coli, laparotomy, surgical patients, bacterial diversity, enteric bacteria, multiple organ failure
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Infections, Bacteriological Techniques, Escherichia coli, Female, Humans, Laparotomy, Lymph Nodes, Male, Middle Aged, Postoperative Complications, Prevalence, Bacterial Translocation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
