The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis
Open accessAbstract
BACKGROUND: Decreased synthesis of the predominant secretory human colonic mucin (MUC2) occurs during active ulcerative colitis. AIMS: To study possible alterations in mucin sulphation and mucin secretion, which could be the cause of decreased mucosal protection in ulcerative colitis. METHODS: Colonic biopsy specimens from patients with active ulcerative colitis, ulcerative colitis in remission, and controls were metabolically labelled with [ 35 S]-amino acids or [ 35 S]-sulphate, chase incubated and analysed by SDS-PAGE, followed by quantitation of mature [ 35 S]-labelled MUC2. For quantitation of total MUC2, which includes non-radiolabelled and radiolabelled MUC2, dot blotting was performed, using a MUC2 monoclonal antibody. RESULTS: Between patient groups, no significant differences were found in [ 35 S]-sulphate content of secreted MUC2 or in the secreted percentage of either [ 35 S]-amino acid labelled MUC2 or total MUC2. During active ulcerative colitis, secretion of [ 35 S]-sulphate labelled MUC2 was significantly increased twofold, whereas [ 35 S]-sulphate incorporation into MUC2 was significantly reduced to half. CONCLUSIONS: During active ulcerative colitis, less MUC2 is secreted, because MUC2 synthesis is decreased while the secreted percentage of MUC2 is unaltered. Furthermore, sulphate content of secreted MUC2 is unaltered by a specific compensatory mechanism, because sulphated MUC2 is preferentially secreted while sulphate incorporation into MUC2 is reduced.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin
Tytgat, K. M. A. J., Büller, H. A., Opdam, F. J. M., Kim, Y. S., Einerhand, A. W. C., & Dekker, J. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90537-1 · Cited by 241
Self-citationMUC2 is the prominent colonic mucin expressed in ulcerative colitis.
Tytgat, K. M., Opdam, F. J., Einerhand, A. W., Büller, H. A., & Dekker, J. (1996) · Gut · doi:10.1136/gut.38.4.554 · Cited by 85
Self-citation
Cited by
Ordás, I., Eckmann, L., Talamini, M., Baumgart, D. C., & Sandborn, W. J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60150-0 · Cited by 2,078
Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684
Self-citationKobayashi, T., Siegmund, B., Le Berre, C., Wei, S. C., Ferrante, M., Shen, B., Bernstein, C. N., Danese, S., Peyrin-Biroulet, L., & Hibi, T. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0205-x · Cited by 1,649
Heazlewood, C. K., Cook, M. C., Eri, R., Price, G. R., Tauro, S. B., Taupin, D., Thornton, D. J., Png, C. W., Crockford, T. L., Cornall, R. J., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050054 · Cited by 701
Intestinal barrier dysfunction in inflammatory bowel diseases
McGuckin, M. A., Eri, R., Simms, L. A., Florin, T. H. J., & Radford-Smith, G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20539 · Cited by 627
Metadata
- Authors
- Van Klinken, B. J.-W., Van der Wal, J.-W. G., Einerhand, A. W. C., Büller, H. A., & Dekker, J.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1999-03-01
- Volume
- 44
- Issue
- 3
- Pages
- 387-393
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2169401839
- Cited by
- 162
- References
- 2
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis. https://app.cochat.ai/papers/10.1136/gut.44.3.387
- The paper
- Van Klinken, B. J.-W., Van der Wal, J.-W. G., Einerhand, A. W. C., Büller, H. A., & Dekker, J. (1999). Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis. Gut. https://doi.org/10.1136/gut.44.3.387
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
