Cited by 313Gastrointestinal motility and disordersMast cells and histamineInflammatory Bowel Disease

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Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat

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Santos, J, Yang, P-C, Söderholm, J D, Benjamin, M, Perdue, M H·2001·Gut

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Abstract

BACKGROUND AND AIMS: Stress may be an important factor in exacerbating inflammatory bowel disease but the underlying mechanism is unclear. Defective epithelial barrier function may allow uptake of luminal antigens that stimulate an immune/inflammatory response. Here, we examined the effect of chronic stress on colonic permeability and the participation of mast cells in this response. METHODS: Mast cell deficient Ws/Ws rats and +/+ littermate controls were submitted to water avoidance stress or sham stress (one hour/day) for five days. Colonic epithelial permeability to a model macromolecular antigen, horseradish peroxidase, was measured in Ussing chambers. Epithelial and mast cell morphology was studied by light and electron microscopy. RESULTS: Chronic stress significantly increased macromolecular flux and caused epithelial mitochondrial swelling in +/+ rats, but not in Ws/Ws rats, compared with non-stressed controls. Stress increased the number of mucosal mast cells and the proportion of cells showing signs of activation in +/+ rats. No mast cells or ultrastructural abnormalities of the epithelium were present in Ws/Ws rats. Increased permeability in +/+ rats persisted for 72 hours after stress cessation. CONCLUSIONS: Chronic stress causes an epithelial barrier defect and epithelial mitochondrial damage, in parallel with mucosal mast cell hyperplasia and activation. The study provides further support for an important role for mast cells in stress induced colonic mucosal pathophysiology.

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Mitochondria and Apoptosis
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832
The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.
Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., FERNÁNDEZ-SUEIRO, J. L., Balish, E., & Hammer, R. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2359 · Cited by 1,156
Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum
Rutgeerts, P., Peeters, M., Hiele, M. I., Vantrappen, G. R., Pennincx, F., Aerts, R., Kerremans, R., & Goboes, K. (1991) · The Lancet · doi:10.1016/0140-6736(91)90663-a · Cited by 758
II. Stress and intestinal barrier function
Söderholm, J. D., & Perdue, M. H. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g7 · Cited by 467
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Levenstein, S., Prantera, C., Varvo, V., Scribano, M. L., Andreoli, A., Luzi, C., Arcà, M., Berto, E., Milite, G., & Marcheggiano, A. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02012.x · Cited by 451
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Drossman, D. A. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00007 · Cited by 388
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Madara, J. (1987) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1987.253.1.c171 · Cited by 342
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Somasundaram, S. G., Rafi, S., Hayllar, J. S., Sigthorsson, G., Jacob, M., Price, A. B., Macpherson, A. J., Mahmod, T., Scott, D. L., Wrigglesworth, J. M., et al. (1997) · Gut · doi:10.1136/gut.41.3.344 · Cited by 314
Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes.
Aloe, L., Bracci‐Laudiero, L., Alleva, E., Lambìase, A., Micera, A., & Tirassa, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10440 · Cited by 258

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Prospective Evaluation of the Relationship Between Stress and Relapse in Ulcerative Colitis
Hart, A. L., Plamondon, S., Emmanuel, A. V., & Kamm, M. A. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318178d1ba
Barrier Function of the Follicle-Associated Epithelium in Stress and Crohn's disease
Keita, Å. V. (2007)
Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
Sand, E. (2010) · Lund University Publications (Lund University)
The Effect of Stress on Gastrointestinal Physiology in Irritable Bowel Syndrome
Park, J. (2012) · Korean Journal of Medicine · doi:10.3904/kjm.2012.82.2.164
A study of mechanisms underlying inflammation-induced abnormal nociceptive signaling from the colon in models of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)
Ibeakanma, C. O. (2011) · QSpace (Queen's University Library)
Evaluation of Frequency of Mastocytic Enterocolitis in Patients with Diarrhea Predominant Irritable Bowel Syndrome and Assessment of Their Response to Mast Cell Inhibitor Therapy
Hassan, V., Bahari, A., Ghafarzadegan, K., Ali, M., Mohammad, K., لاری, س., Farzad, S., & Amirmajdi, E. M. (2014) · مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
MAST HÜCRELERİNİN ENFLAMASYONDAKİ ROLÜ: İNSAN VE DENEYSEL HAYVAN MODELLERİ ÜZERİNDE YAPILAN ÇALIŞMALARIN DEĞERLENDİRİLMESİ
Ercan, F., & Çetınel, Ş. (2008) · DergiPark (Istanbul University)
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Jedel, S., Hankin, V., Voigt, R. M., & Keshavarzian, A. (2012)
Función Barrera Epitelial en un Modelo de Disfunción Intestinal Inducido por Parasitosis con Trichinella spiralis en la Rata
Blanco, F., & Antoni, J. (2012) · TDX (Tesis Doctorals en Xarxa)
Inflammation in irritable bowel syndrome: Myth or new treatment target? 2016 Irritable Bowel Syndrome: Global view
Sinagra, E., Rossi, F., Raimondo, D., Pietra, C., Pisciotto, P., Pompei, G., Tomasello, G., Cappello, F., Morreale, G. C., Amvrosiadis, G., et al. (2016)
El mastocito: célula clave en la microinflamación intestinal y en la regulación de la función barrera mediada por el estrés en el síndrome del intestino irritable con predominio de diarrea
Guilarte, M. (2014) · TDX (Tesis Doctorals en Xarxa)
Criopreservação de sêmen humano em meio Test Yolk Buffer ou meio sintético suplementado com fosfolipídio e antioxidante: ensaio clínico controlado
Silva, A. B. (2018) · doi:10.11606/d.17.2018.tde-23032018-121409
Efeito protetor do estradiol na disfunção da barreira epitelial intestinal induzida pela endotoxemia
Ribeiro, A. B. (2018) · doi:10.11606/t.17.2018.tde-23072018-094941
Evaluation of Food Specific Immunoglobulin G (IgG)-Guided Exclusion Diet in the Treatment of Irritable Bowel Syndrome and Inflammatory Bowel disease
Uzunısmaıl, H. (2020) · Edelweiss Journal of Biomedical Research and Review · doi:10.33805/2690-2613.110
Neuro-immuno-regulation of inflammation in the colonic mucosa : Focus on mast cells and eosinophils in bowel disorders
Bedmar, M. T. C. (2020) · Linköping University medical dissertations · doi:10.3384/diss.diva-171432
erve Growth Factor Mediates Alterations of Colonic Sensitivity nd Mucosal Barrier Induced by Neonatal Stress in Rats
Barreau, R. (2004)
Therapeutic role and importance of gut microbiota in brain and related disorder: A review
Kundu Smita, S., & Rana, D. G. (2021) · Asian Journal of Pharmacy and Pharmacology · doi:10.31024/ajpp.2021.7.1.6
Morphological manifestations of irritable bowel syndrome
Stepanov, Y. М., Budzak, I. Y., & Gaidar, Y. А. (2021) · GASTROENTEROLOGY · doi:10.22141/2308-2097.55.2.2021.233635
스트레스에 의한 소화 생리학적 변화: 과민성 장증후군 발생과 관련하여
Park, J. H. (2012)
鹿鸣春回辽北职教谱金曲——记西丰职教中心
田绍平 (2004) · 职业技术教育研究
Characterization of Colonic Macrophages in Mice Exposed to Social Stressor During Oral Challenge with Citrobacter rodentium.
Easterling, R. S. (2013) · The Knowledge Bank (The Ohio State University)
State-of-the Art Lecture: Irritable bowel syndrome: the new inflammatory bowel disease?
Spiller, R. E. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5702-1_31
Nutritional Support in Stroke Neurorehabilitation
Herguedas, A. J. U., & González, E. J. G. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106180
What factors contribute to the prevalence of allergic diseases in the contemporary era?Preprint
He, T., & Weiqing, Q. (2023) · doi:10.22541/au.169267947.73061246/v1

Authors: Santos, J., Yang, P.-C., Söderholm, J. D., Benjamin, M., & Perdue, M. H.
Affiliations: McMaster University (CA)
Corresponding author: Perdue, M H
ORCID: Santos, J
Söderholm, J D
Venue: Gut
Publisher: BMJ
Published: 2001-05-01
Volume: 48
Issue: 5
Pages: 630-636
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.48.5.630
PMC: PMC1728291
OpenAlex: W2141354880
Cited by: 313
References: 46
Citations by year: 2026: 2 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 11 · 2021: 11 · 2020: 16 · 2019: 18 · 2018: 13 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 10 · 2013: 16 · 2012: 22
FWCI: 6.35
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: mast cells, chronic stress, colonic permeability, inflammatory bowel disease, water avoidance stress, mitochondrial swelling, mast cell activation
MeSH terms: Analysis of Variance, Animals, Cell Membrane Permeability, Electric Conductivity, Gastrointestinal Transit, Horseradish Peroxidase, Intestinal Mucosa, Mast Cells, Microscopy, Electron, Mitochondria, Rats, Mutant Strains, Stress, Psychological, Statistics, Nonparametric, Rats

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Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat

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