The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract
Open accessAbstract
Background: Sonic hedgehog (Shh) is an important endodermal morphogenetic signal during the development of the vertebrate gut. It controls gastrointestinal patterning in general, and gastric gland formation in particular. We have previously shown that Shh regulates gastric gland proliferation in the adult but detailed analysis of its expression along the adult gastrointestinal tract has never been undertaken. We therefore studied Shh expression along the normal human and rodent adult gastrointestinal tract as well as in intestinal metaplasia of the stomach, gastric and intestinal metaplasia of the oesophagus, and gastric heterotopia in Meckel’s diverticulum. Methods: The studies were performed with in situ hybridisation and by immunohistochemistry using an antibody that recognises the Shh precursor form. Results: We found that in the normal gastrointestinal tract, high levels of Shh were expressed in the fundic glands of the stomach. Shh expression was also found in fundic gland metaplasia and heterotopia. However, Shh expression was lost in intestinal metaplasia of the stomach. Conclusion: We found a strong correlation between Shh expression and fundic gland differentiation. Our current study therefore provides evidence that in addition to its role in gastric epithelial development, Shh plays a unique role in gastric epithelial differentiation in adults.
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Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370
Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin
Tytgat, K. M. A. J., Büller, H. A., Opdam, F. J. M., Kim, Y. S., Einerhand, A. W. C., & Dekker, J. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90537-1 · Cited by 241
Cited by
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
van den Brink, G. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00054.2006 · Cited by 301
Self-citationWei, D., Gong, W., Kanai, M., Schlunk, C., Wang, L., Yao, J. C., Wu, T.-T., Huang, S., & Xie, K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3619 · Cited by 299
McDonald, S. A. C., Greaves, L. C., Gutierrez–Gonzalez, L., Rodriguez–Justo, M., Deheragoda, M., Leedham, S. J., Taylor, R. W., Lee, C. Y., Preston, S. L., Lovell, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.035 · Cited by 242
Metadata
- Authors
- van den Brink, G. R., Hardwick, J. C. H., Nielsen, C., Xu, C., ten Kate, F. J., Glickman, J., van Deventer, S. J. H., Roberts, D. J., & Peppelenbosch, M. P.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2002-11
- Volume
- 51
- Issue
- 5
- Pages
- 628-633
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2138556068
- Cited by
- 169
- References
- 2
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van den Brink, G. R., Hardwick, J. C. H., Nielsen, C., Xu, C., ten Kate, F. J., Glickman, J., van Deventer, S. J. H., Roberts, D. J., & Peppelenbosch, M. P. (2002). Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut. https://doi.org/10.1136/gut.51.5.628
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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