The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Obesity and colorectal cancer
Abstract
Excess body weight, as defined by the body mass index (BMI), has been associated with several diseases and includes subjects who are overweight (BMI≥25–29.9 kg/m 2 ) or obese (BMI≥30 kg/m 2 ). Overweight and obesity constitute the fifth leading risk for overall mortality, accounting for at least 2.8 million adult deaths each year. In addition around 11% of colorectal cancer (CRC) cases have been attributed to overweight and obesity in Europe. Epidemiological data suggest that obesity is associated with a 30–70% increased risk of colon cancer in men, whereas the association is less consistent in women. Similar trends exist for colorectal adenoma, although the risk appears lower. Visceral fat, or abdominal obesity, seems to be of greater concern than subcutaneous fat obesity, and any 1 kg/m 2 increase in BMI confers additional risk (HR 1.03). Obesity might be associated with worse cancer outcomes, such as recurrence of the primary cancer or mortality. Several factors, including reduced sensitivity to antiangiogenic-therapeutic regimens, might explain these differences. Except for wound infection, obesity has no significant impact on surgical procedures. The underlying mechanisms linking obesity to CRC are still a matter of debate, but metabolic syndrome, insulin resistance and modifications in levels of adipocytokines seem to be of great importance. Other biological factors such as the gut microbita or bile acids are emerging. Many questions still remain unanswered: should preventive strategies specifically target obese patients? Is the risk of cancer great enough to propose prophylactic bariatric surgery in certain patients with obesity?
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Cited by
Rex, D. K., Boland, C. R., Dominitz, J. A., Giardiello, F. M., Johnson, D. A., Kaltenbach, T., Levin, T. R., Lieberman, D., & Robertson, D. J. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.013 · Cited by 729
Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women
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High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites
Yang, J., Wei, H., Zhou, Y., Szeto, C.-H., Li, C., Lin, Y., Coker, O. O., Lau, H. C. H., Chan, A. W. H., Sung, J. J. Y., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.08.041 · Cited by 536
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
Sun, L., Cai, J., & Gonzalez, F. J. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00404-2 · Cited by 435
Stefani, C., Miricescu, D., Stanescu-Spinu, I.-I., Nica, R. I., Greabu, M., Totan, A. R., & Jinga, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910260 · Cited by 402
Metadata
- Authors
- Bardou, M., Barkun, A. N., & Martel, M.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2013-03-12
- Volume
- 62
- Issue
- 6
- Pages
- 933-947
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2118224153
- Cited by
- 815
- References
- 169
- FWCI
- 26.56
- Type
- journal article
- Language
- en
- Open access
- closed
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