Cited by 312Colorectal Cancer Screening and DetectionGut microbiota and healthGenetic factors in colorectal cancer

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index, and 1 are not checked yet.

Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia

Open access

Wong, Sunny H, Kwong, Thomas N Y, Chow, Tai-Cheong, Luk, Arthur K C, Dai, Rudin Z W, Nakatsu, Geicho, Lam, Thomas Y T, Zhang, Lin, Wu, Justin C Y, Chan, Francis K L, Ng, Simon S M, Wong, Martin C S, Ng, Siew C, Wu, William K K, Yu, Jun, Sung, Joseph J Y·2017·Gut

DOI 10.1136/gutjnl-2016-312766PMC PMC5530471

Open this paper in CoChat — free account Open PDF

Abstract

Objective There is a need for an improved biomarker for colorectal cancer (CRC) and advanced adenoma. We evaluated faecal microbial markers for clinical use in detecting CRC and advanced adenoma. Design We measured relative abundance of Fusobacterium nucleatum (Fn), Peptostreptococcus anaerobius (Pa) and Parvimonas micra (Pm) by quantitative PCR in 309 subjects, including 104 patients with CRC, 103 patients with advanced adenoma and 102 controls. We evaluated the diagnostic performance of these biomarkers with respect to faecal immunochemical test (FIT), and validated the results in an independent cohort of 181 subjects. Results The abundance was higher for all three individual markers in patients with CRC than controls (p<0.001), and for marker Fn in patients with advanced adenoma than controls (p=0.022). The marker Fn, when combined with FIT, showed superior sensitivity (92.3% vs 73.1%, p<0.001) and area under the receiver-operating characteristic curve (AUC) (0.95 vs 0.86, p<0.001) than stand-alone FIT in detecting CRC in the same patient cohort. This combined test also increased the sensitivity (38.6% vs 15.5%, p<0.001) and AUC (0.65 vs 0.57, p=0.007) for detecting advanced adenoma. The performance gain for both CRC and advanced adenoma was confirmed in the validation cohort (p=0.0014 and p=0.031, respectively). Conclusions This study identified marker Fn as a valuable marker to improve diagnostic performance of FIT, providing a complementary role to detect lesions missed by FIT alone. This simple approach may improve the clinical utility of the current FIT, and takes one step further towards a non-invasive, potentially more accurate and affordable diagnosis of advanced colorectal neoplasia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/gutjnl-2016-312766

Cites

32 of 33 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 The diagnostic performance of faecal immunochemical test (FIT), marker Fusobacterium nucleatum (Fn) and their combined test. Sensitivity and area under the receiver-operating characteristic curve (AUC) for diagnosing colorectal cancer (A) and advanced adenoma (B). ***p<0.001.CC BY-NC · PubMed Central

Figure 2 The diagnostic performance of faecal immunochemical test (FIT), marker Fusobacterium nucleatum (Fn) and their combined test indicated by the receiver operating characteristic (ROC) curve analysis for colorectal cancer in the discovery (A) and validation (B) cohorts. ***p<0.001. AUC, area under the receiver-operating characteristic curve.CC BY-NC · PubMed Central

Figure 3 The colorectal cancer samples detected by faecal immunochemical test (FIT) (red), missed by FIT and detected by marker Fusobacterium nucleatum (Fn) (blue), and missed by both tests (yellow). The dotted lines indicate the threshold of the individual test above which samples are regarded as positive.CC BY-NC · PubMed Central

Figure 4 The sensitivities of faecal immunochemical test (FIT), marker Fusobacterium nucleatum (Fn) and the combined test stratified by clinical stage (A), and location of the colorectal cancer (CRC) (B).CC BY-NC · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. D., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,468
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718
Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043
Multitarget Stool DNA Testing for Colorectal-Cancer Screening
Imperiale, T. F., Ransohoff, D. F., Itzkowitz, S. H., Levin, T. R., Lavin, P., Lidgard, G. P., Ahlquist, D. A., & Berger, B. M. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311194 · Cited by 1,900
Quality indicators for colonoscopy
Rex, D. K., Schoenfeld, P. S., Cohen, J., Pike, I. M., Adler, D. G., Fennerty, M. B., Lieb, J. G., Park, W. G., Rizk, M. K., Sawhney, M. S., et al. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2014.07.058 · Cited by 1,764
Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial
Atkin, W. S., Edwards, R., Kralj‐Hans, I., Wooldrage, K., Hart, A. R., Northover, J. M. A., Parkin, D. M., Wardle, J., Duffy, S. W., & Cuzick, J. M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60551-x · Cited by 1,618
Gut microbiome development along the colorectal adenoma-carcinoma sequence
Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms7528 · Cited by 1,506
American College of Gastroenterology Guidelines for Colorectal Cancer Screening 2008
Rex, D. K., Johnson, D. A., Anderson, J. C., Schoenfeld, P. S., Burke, C. A., & Inadomi, J. M. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.104 · Cited by 1,397
Potential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375

Show all 32 references

Sorted by citations

Items 101–200 of 312

Shifts in gut microbiome and metabolome are associated with risk of recurrent atrial fibrillation
Li, J., Zuo, K., Zhang, J., Hu, C., Wang, P., Jiao, J., Liu, Z., Yin, X., Liu, X., Li, K., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15959 · Cited by 41
Detection of Fusobacterium nucleatum in feces and colorectal mucosa as a risk factor for colorectal cancer: a systematic review and meta-analysis
Janati, A. I., Karp, I., Laprise, C., Sabri, H., & Emami, E. (2020) · Systematic Reviews · doi:10.1186/s13643-020-01526-z · Cited by 42
Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?
Tarashi, S., Siadat, S. D., Badi, S. A., Zali, M. R., Biassoni, R., Ponzoni, M., & Moshiri, A. (2019) · Microorganisms · doi:10.3390/microorganisms7110561 · Cited by 39
Colorectal carcinogenesis: an archetype of gut microbiota–host interaction
Alexander, J. L., Scott, A. J., Pouncey, A. L., Marchesi, J. R., Kinross, J. K., & TEARE, J. P. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.865 · Cited by 38
Establishing a novel colorectal cancer predictive model based on unique gut microbial single nucleotide variant markers
Ma, C., Chen, K., Wang, Y., Cen, C., Zhai, Q., & Zhang, J. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1869505 · Cited by 39
Fusobacterium Nucleatum-Induced Tumor Mutation Burden Predicts Poor Survival of Gastric Cancer Patients
Hsieh, Y., Kuo, W.-L., Hsu, W.-T., Tung, S., & Li, C. (2022) · Cancers · doi:10.3390/cancers15010269 · Cited by 38
The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress
El-Baz, A. M., Shata, A., Hassan, H. M., El‐Sokkary, M. M. A., & Khodir, A. E. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107757 · Cited by 37
Human Gut Microbiome-Based Knowledgebase as a Biomarker Screening Tool to Improve the Predicted Probability for Colorectal Cancer
Zhou, Z., Ge, S., Li, Y., Ma, W., Liu, Y., Hu, S., Zhang, R., Ma, Y., Du, K., Syed, A., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.596027 · Cited by 33
Fecal Enterotoxigenic Bacteroides fragilis–Peptostreptococcus stomatis–Parvimonas micra Biomarker for Noninvasive Diagnosis and Prognosis of Colorectal Laterally Spreading Tumor
Shen, X., Li, J., Li, J., Zhang, Y., Li, X., Cui, Y., Gao, Q., Chen, X., Chen, Y., & Fang, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.661048 · Cited by 33
The Composition of Colonic Commensal Bacteria According to Anatomical Localization in Colorectal Cancer
Zhao, L., Zhang, X., Zuo, T., & Yu, J. Q. (2017) · Engineering · doi:10.1016/j.eng.2017.01.012 · Cited by 35
Self-citation
Study Insights into Gastrointestinal Cancer through the Gut Microbiota
Kong, F., & Cai, Y. (2019) · BioMed Research International · doi:10.1155/2019/8721503 · Cited by 33
The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis
Datorre, J. G., de Carvalho, A. C., Guimarães, D. P., & Reis, R. M. (2020) · Pathobiology · doi:10.1159/000512175 · Cited by 32
Colorectal carcinoma screening: Established methods and emerging technology
Hissong, E. M., & Pittman, M. E. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1670614 · Cited by 33
Circulating microbiome DNA: An emerging paradigm for cancer liquid biopsy
Chen, H., Ma, Y., Liu, Z., Li, J., Li, X., Yang, F., & Qiu, M. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.08.036 · Cited by 32
Development and validation of a panel of five proteins as blood biomarkers for early detection of colorectal cancer
Chen, H., Qian, J., Werner, S., Ćuk, K., Knebel, P., & Brenner, H. (2017) · Clinical Epidemiology · doi:10.2147/clep.s144171 · Cited by 30
Diagnostic Performance of Intestinal Fusobacterium nucleatum in Colorectal Cancer
Peng, B., Cao, C.-Y., Li, W., Zhou, Y., Zhang, Y., Nie, Y., Cao, Y., & Li, Y. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.232814 · Cited by 30
A novel therapeutic combination of dapagliflozin, Lactobacillus and crocin attenuates diabetic cardiomyopathy in rats: Role of oxidative stress, gut microbiota, and PPARγ activation
Khalaf, E. M., Hassan, H. M., El-Baz, A. M., Shata, A., Khodir, A. E., Yousef, M. E., Elgharabawy, R. M., Nouh, N. A. T., Saleh, S., Bin-Meferij, M. M., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175172 · Cited by 30
Genetic and epigenetic markers in colorectal cancer screening: recent advances
Singh, M. P., Rai, S., Suyal, S., Singh, S. K., Singh, S. K., Agarwal, A., & Srivastava, S. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1337511 · Cited by 30
Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer
Löwenmark, T., Li, X., Löfgren‐Burström, A., Zingmark, C., Ling, A., Kellgren, T. G., Larsson, P. G., Ljuslinder, I., Wai, S. N., Edin, S., et al. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03179-4 · Cited by 29
Gut microbiome in tumorigenesis and therapy of colorectal cancer
Wang, L., Yu, K., Hou, Y., Guo, M., Yao, F., & Chen, Z. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30917 · Cited by 31
Exploring the interplay between Fusobacterium nucleatum with the expression of microRNA, and inflammatory mediators in colorectal cancer
Bostanghadiri, N., Razavi, S., Shariati, A., Talebi, M., Mirkalantari, S., Razavi, À. E., & Darban‐Sarokhalil, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1302719 · Cited by 27
Unveiling the Hidden Links: Periodontal Disease, Fusobacterium Nucleatum, and Cancers
Akbari, E., Epstein, J. B., & Samim, F. (2024) · Current Oncology Reports · doi:10.1007/s11912-024-01591-w · Cited by 30
Diagnostic accuracy of Fusobacterium nucleatum IgA and IgG ELISA test in colorectal cancer
Kurt, M., & Yumuk, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-81171-1 · Cited by 27
Berberine might block colorectal carcinogenesis by inhibiting the regulation of B-cell function by Veillonella parvula
Qian, Y., Kang, Z., Zhao, L., Chen, H., Zhou, C., Gao, Q., Wang, Z., Liu, Q., Cui, Y., Li, X., et al. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002752 · Cited by 27
Noninvasive early diagnosis of intestinal diseases based on artificial intelligence in genomics and microbiome
Zhang, W., Chen, X., & Wong, K. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15500 · Cited by 25
Fusobacterium Nucleatum Is a Risk Factor for Metastatic Colorectal Cancer
Chen, W., Zhang, X., Zhang, Y.-P., Yue, C.-B., Wang, Y.-L., Pan, H., Zhang, Y., Liu, H., & Zhang, Y. (2022) · Current Medical Science · doi:10.1007/s11596-022-2597-1 · Cited by 26
Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract
Guo, S., Wang, H., Nian, Z., Wang, Y.-D., Zeng, Q., & Zhang, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-11127-x · Cited by 27
A framework for effective application of machine learning to microbiome-based classification problemsPreprint
Topçuoğlu, B. D., Lesniak, N. A., Ruffin, M. T., Wiens, J., & Schloss, P. D. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/816090 · Cited by 26
Supplementation of triple viable probiotics combined with dietary intervention is associated with gut microbial improvement in humans on a high‑fat diet
Qian, L., Gao, R., Huang, J., & Qin, H. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7801 · Cited by 25
Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract
Harold, K. M., MacCuaig, W. M., Charkrabarty, J. H., Williams, K. M., Hill, K. B., Arreola, A. X., Sekhri, M., Carter, S., Gómez-Gutiérrez, J. G., Salem, G., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416109 · Cited by 23
Statistical modeling of gut microbiota for personalized health status monitoring
Zhu, J., Xie, H., Yang, Z., Chen, J., Yin, J., Tian, P., Wang, H., Zhao, J., Zhang, H., Lu, W., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01614-x · Cited by 24
Biomarkers to Detect Early-Stage Colorectal Cancer
Keenan, J. I., & Frizelle, F. (2022) · Biomedicines · doi:10.3390/biomedicines10020255 · Cited by 22
Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a pilot study
Idrissi Janati, A., Karp, I., Von Renteln, D., Bouin, M., Liu, Y., Tran, S. D., & Emami, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-09587-x · Cited by 21
Guizhi Shaoyao Zhimu decoction inhibits neutrophil extracellular traps formation to relieve rheumatoid arthritis via gut microbial outer membrane vesicles
Ye, H., Wang, H., Han, B., Chen, K., Wang, X., Ma, F., Cheng, L., Zheng, S., Zhao, X., Zhu, J., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156254 · Cited by 21
A fecal-based test for the detection of advanced adenoma and colorectal cancer: a case-control and screening cohort study
Cao, L., Peng, X., Xue, W., Zhang, R., Zhang, J., Zhou, T., Wu, Z., Li, G.-R., Wang, T., He, Y., et al. (2021) · BMC Medicine · doi:10.1186/s12916-021-02123-0 · Cited by 22
Enhanced Metagenomic Deep Learning for Disease Prediction and Reproducible Signature Identification by Restructured Microbiome 2D-Representations
Shen, W. X., Liang, S. R., Jiang, Y., & Chen, Y. (2022) · Patterns · doi:10.1016/j.patter.2022.100658 · Cited by 21
Fusobacterium nucleatum produces cancer stem cell characteristics via EMT-resembling variations.
Wang, Q. L., Chen, Y., Yue, C., & Liu, X. (2020) · PubMed Central · Cited by 21
Role of Microbial Infection-Induced Inflammation in the Development of Gastrointestinal Cancers
Kouzu, K., Tsujimoto, H., Kishi, Y., Ueno, H., & Shinomiya, N. (2021) · Medicines · doi:10.3390/medicines8080045 · Cited by 22
Detection of Colorectal Carcinoma Based on Microbiota Analysis Using Generalized Regression Neural Networks and Nonlinear Feature Selection
Arabameri, A., Asemani, D., & Teymourpour, P. (2018) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2018.2870124 · Cited by 20
Fusobacterium�nucleatum‑positive colorectal cancer (Review)
Yang, Z., & Ji, G. (2019) · Oncology Letters · doi:10.3892/ol.2019.10433 · Cited by 20
Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients
Löwenmark, T., Köhn, L., Kellgren, T. G., Rosenbaum, W., Bronnec, V., Löfgren‐Burström, A., Zingmark, C., Larsson, P. G., Dahlberg, M. L., Schroeder, B. O., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05720-8 · Cited by 19
The Gut Microbiome and Its Multifaceted Role in Cancer Metabolism, Initiation, and Progression: Insights and Therapeutic Implications
Xu, K., Motiwala, Z. Y., Corona‐Avila, I., Makhanasa, D., Alkahalifeh, L., & Khan, M. W. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338251331960 · Cited by 22
Leveraging Fecal Microbial Markers to Improve the Diagnostic Accuracy of the Fecal Immunochemical Test for Advanced Colorectal Adenoma
Zhang, Y., Lu, M., Lu, B., Liu, C., Ma, Y., Liu, L., Miao, X., Qin, J., Chen, H., & Dai, M. (2020) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000389 · Cited by 18
Effects of n-acetyl-cysteine supplementation in late gestational diet on maternal-placental redox status, placental NLRP3 inflammasome, and fecal microbiota in sows1.
Luo, Z., Xu, X., Sho, T., Luo, W., Zhang, J., Xu, W., Yao, J., & Xu, J. (2019) · Europe PMC (PubMed Central) · doi:10.1093/jas/skz058 · Cited by 18
Novel Biomarkers in the Diagnosis of Benign and Malignant Gastrointestinal Diseases
Jonaitis, P., Kiudelis, V., Streleckienė, G., Gedgaudas, R., Skiecevičienė, J., & Kupčinskas, J. (2021) · Digestive Diseases · doi:10.1159/000515522 · Cited by 17
Valuable effects of lactobacillus and citicoline on steatohepatitis: role of Nrf2/HO-1 and gut microbiota
El-Baz, A. M., El-Ganiny, A. M., Hellal, D., Anwer, H. M., El-Aziz, H. A. A., Tharwat, I. E., El-Adawy, M. A., Helal, S. E.-D. M., Mohamed, M. T. A., Azb, T. M., et al. (2023) · AMB Express · doi:10.1186/s13568-023-01561-8 · Cited by 17
Colorectal Cancer Screening in Inflammatory Bowel Diseases—Can Characterization of GI Microbiome Signatures Enhance Neoplasia Detection?
Pratt, M., Forbes, J. D., Knox, N., Domselaar, G. V., & Bernstein, C. N. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.12.287 · Cited by 19
A novel promising diagnosis model for colorectal advanced adenoma and carcinoma based on the progressive gut microbiota gene biomarkers
Xu, J., Zheng, Z., Yang, L., Li, R., Ma, X., Zhang, J., Yin, F., Liu, L., Xu, Q., Shen, Q., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00940-1 · Cited by 17
The association between Fusobacterium nucleatum and cancer colorectal: A systematic review and meta-analysis
Villar-Ortega, P., Ruíz, M. E., Gutiérrez-Soto, M., Jiménez, M. R.-C., Navarro‐Marí, J. M., & Fernández, J. G. (2022) · Enfermedades infecciosas y microbiologia clinica (English ed ) · doi:10.1016/j.eimce.2022.02.007 · Cited by 17
Gut microbiota alterations in colorectal adenoma-carcinoma sequence based on 16S rRNA gene sequencing: A systematic review and meta-analysis
Wu, Y., Xiong, J., Zhan, C.-N., & Xu, H. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106889 · Cited by 17
Fecal fusobacterium nucleatum for detecting colorectal cancer: a systematic review and meta-analysis
Huang, Q., Peng, Y., & Xie, F. (2018) · The International Journal of Biological Markers · doi:10.1177/1724600818781301 · Cited by 16
Fecal Fusobacterium nucleatum as a predictor for metachronous colorectal adenoma after endoscopic polypectomy
Xue, J., Xie, Y., Zou, T., Qian, Y., Kang, Z., Zhou, C., Pan, S., Xia, T., Chen, Y., & Fang, J. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15559 · Cited by 16
Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/β-Catenin Pathway
Zhou, Z., Wang, Y., Ji, R., Zhang, D., Ma, C., Ma, W., Ma, Y., Jiang, X., Du, K., Zhang, R., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.841918 · Cited by 16
Gut microbiome and gastric cancer: microbial interactions and therapeutic potential
El-Ghannam, M., Hassanien, M. H., Ameen, Y. A., Turky, E. A., ELattar, G. M., Ray, A. A. E., & Eltalkawy, M. D. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00729-w · Cited by 16
Insights into the oral microbiota in human systemic cancers
Su, L., Yang, R., Sheng, Y., Ullah, S., Zhao, Y., Shunjiayi, H., Zhao, Z., & Wang, Q. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1369834 · Cited by 15
Investigating the causal relationship of gut microbiota with GERD and BE: a bidirectional mendelian randomization
Liu, Y., Yu, J., Yang, Y., Han, B., Wang, Q., & Du, S. (2024) · BMC Genomics · doi:10.1186/s12864-024-10377-0 · Cited by 15
Self-citation
Predictive Value of a Gastric Microbiota Dysbiosis Test for Stratifying Cancer Risk in Atrophic Gastritis Patients
Zaramella, A., Arcidiacono, D., Duci, M., Benna, C., Pucciarelli, S., Fantin, A., Rosato, A., Re, V. D., Cannizzaro, R., Fassan, M., et al. (2024) · Nutrients · doi:10.3390/nu17010142 · Cited by 15
Our Microbiome: On the Challenges, Promises, and Hype
Federici, S., Suez, J., & Elinav, E. (2020) · Results and problems in cell differentiation · doi:10.1007/978-3-030-51849-3_20 · Cited by 15
Bacteria-Mediated Oncogenesis and the Underlying Molecular Intricacies: What We Know So Far
Prasad, S. K., Bhat, S., Shashank, D., Akshatha, C. R., Sindhu, R., Rachtanapun, P., Devegowda, D., Santhekadur, P. K., & Sommano, S. R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.836004 · Cited by 15
Long-term follow-up of colorectal cancer screening attendees identifies differences in Phascolarctobacterium spp. using 16S rRNA and metagenome sequencing
Bucher-Johannessen, C., Birkeland, E. E., Vinberg, E., Bemanian, V., Hoff, G. S., Berstad, P. M., & Rounge, T. B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1183039 · Cited by 16
A Peptide‐Derived Aggregation‐Induced Emission Nanobioprobe: Unlocking Selective Detection of Fusobacterium nucleatum and Noninvasive Screening of Colorectal Cancer
Liu, H., Wu, T., Yu, Y., Xin, Y., Lu, H., Zhao, S., Su, M., Ga, L., Dong, A., Elsabahy, M., et al. (2025) · Aggregate · doi:10.1002/agt2.740 · Cited by 14
Dynamic interplay of intratumoral microbiota within the colorectal cancer microenvironment
Wu, Y., Wang, P., Zhao, X., Liu, T., Situ, B., & Zheng, L. (2023) · Open Research (University of Surrey) · doi:10.1002/viw.20230100 · Cited by 14
Both endogenous and exogenous miR-139–5p inhibit Fusobacterium nucleatum-related colorectal cancer development
Zhao, Y., Tao, Q., Li, S., Zheng, P., Liu, J., & Liang, X. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173459 · Cited by 14
Fusobacterium nucleatum in Health and Disease
Yang, X., Zhang, S., Ning, T., & Wu, J. (2025) · MedComm · doi:10.1002/mco2.70465 · Cited by 15
Self-citation
Beta-defensin index: A functional biomarker for oral cancer detection
Ghosh, S. K., Man, Y., Fraiwan, A., Waters, C., McKenzie, C., Lu, C. Y., Pfau, D., Kawsar, H. I., Bhaskaran, N., Pandiyan, P., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101447 · Cited by 13
Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies
Yu, L.-C., Li, Y.-P., Xin, Y.-M., Mao, M., Pan, Y.-X., Qu, Y.-X., Luo, Z.-D., Zhang, Y., & Zhang, X. (2024) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v16.i6.2271 · Cited by 13
Potential and application of Fusobacterium nucleatum in the diagnosis and treatment of colorectal cancer
He, X., Zhao, Q., Zhang, J., Shi, J., Wan, N., Tang, B., Tian, B., & Li, P. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1652702 · Cited by 12
Future of Colorectal Cancer Screening: From One-Size-FITs-All to Tailor-Made
Kortlever, T. L., Vlugt, M. V., & Dekker, E. (2022) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2022.906052 · Cited by 12
Biomarker discovery and validation for gastrointestinal tumors: A comprehensive review of colorectal, gastric, and liver cancers
Hakami, Z. H. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155216 · Cited by 12
Elucidating the genotoxicity of Fusobacterium nucleatum-secreted mutagens in colorectal cancer carcinogenesis
Xu, W., Zhang, Y., Chen, D.-J., Huang, D., Zhao, Y., Hu, W., Lin, L., Liu, Y., Wang, S., Zeng, J., et al. (2024) · Gut Pathogens · doi:10.1186/s13099-024-00640-w · Cited by 13
Self-citation
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury
Xie, M., Zheng, J., Yao, Y., Yang, Q., Zhou, Z., Xue, J., Wang, B., Qiu, Y., Zhu, Z., Sun, Q., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102373 · Cited by 11
Synthetic biology strategies for engineering probiotics and commensal bacteria for diagnostics and therapeutics
Nam, J., Lee, Y., Lee, S., Choi, H., Lee, S. Y., & Yang, D. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108782 · Cited by 11
The Regional Specificity of Mucosa-Associated Microbiota in Patients with Distal Colorectal Cancer
Kono, Y., Inoüe, R., Teratani, T., Tojo, M., Kumagai, Y., Morishima, S., Koinuma, K., Lefor, A. K., Kitayama, J., Sata, N., et al. (2021) · Digestion · doi:10.1159/000519487 · Cited by 12
Is this the end of colonoscopy screening for colorectal cancer? An Asia‐Pacific perspective
Lui, R. N.-S., Wong, S. H., Ding, N. S., Sekiguchi, M., Yu, J. Q., Ang, T. L., Yeoh, K., Chiu, H., & Sung, J. J. �. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16182 · Cited by 11
Self-citation
Association of Fusobacterium nucleatum infection with the clinicopathological characteristics in colorectal cancer patients
Pang, S.-W., Armon, S., Chook, J. B., Chew, J., Peh, K.-B., Lim, W. W.-D., Peh, S. C., & Teow, S. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09150-5 · Cited by 11
Integrated analysis of intestinal microbiota and host gene expression in colorectal cancer patients
Chen, Y., Si, H., Bao, B., Li, S., Teng, D., Yang, Y., Hu, S., Xu, Y., & Du, X. (2022) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001596 · Cited by 10
Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming
Jones, J. P., Shi, Q., Nath, R. R., & Brito, I. (2024) · PLoS ONE · doi:10.1371/journal.pone.0297897 · Cited by 12
Gut microbiome and colorectal cancer: From pathogenesis to treatment
Lahouty, M., Fadaee, M., Aghaei, R., Alizadeh, F., Jafari, A., & Sharifi, Y. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156034 · Cited by 10
Microbe-driven immune suppression in colorectal cancer: the Fusobacterium nucleatum playbook
Wuyi, W., & Tao, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1795703 · Cited by 12
Detection of Fusobacterium nucleatum DNA in primary care patient stool samples does not predict progression of colorectal neoplasia
Aitchison, A., Pearson, J. F., Purcell, R. V., Frizelle, F., & Keenan, J. I. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269541 · Cited by 10
Use of Personalized Biomarkers in Metastatic Colorectal Cancer and the Impact of AI
Volovăț, S. R., Augustin, I. G., Zob, D., Boboc, D., Amurariti, F., Volovat, C. D., Ştefănescu, C., Stolniceanu, C. R., Ciocoiu, M., Dumitras, E. A., et al. (2022) · Cancers · doi:10.3390/cancers14194834 · Cited by 10
Global research on the crosstalk between intestinal microbiome and colorectal cancer: A visualization analysis
Yang, S., Hao, S., Ye, H., & Zhang, X. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1083987 · Cited by 10
Gastrointestinal Pathobionts in Pediatric Crohn’s Disease Patients
Purcell, R. V., Kaakoush, N. O., Mitchell, H. M., Pearson, J. F., & Keenan, J. I. (2018) · International Journal of Microbiology · doi:10.1155/2018/9203908 · Cited by 10
Recent advancements in the exploitation of the gut microbiome in the diagnosis and treatment of colorectal cancer
Stott, K. J., Phillips, B., Parry, L., & May, S. (2021) · Bioscience Reports · doi:10.1042/bsr20204113 · Cited by 10
Vinpocetine and Lactobacillus improve fatty liver in rats: role of adiponectin and gut microbiome
El-Baz, A. M., Shata, A., Nouh, N. A. T., Jamil, L., Hafez, M. M., Negm, S., El-kott, A. F., AlShehri, M. A., & Khalaf, E. M. (2024) · AMB Express · doi:10.1186/s13568-024-01731-2 · Cited by 9
Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett’s Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations
Zaramella, A., Arcidiacono, D., Nucci, D., Fabris, F., Benna, C., Pucciarelli, S., Fassan, M., Fantin, A., Re, V. D., Cannizzaro, R., et al. (2023) · Nutrients · doi:10.3390/nu15132885 · Cited by 9
Akkermansia muciniphila as a Model Case for the Development of an Improved Quantitative RPA Microbiome Assay
Goux, H. J., Chavan, D., Crum, M., Kourentzi, K. D., & Willson, R. C. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00237 · Cited by 9
The effects of a mixture of Lactobacillus species on colorectal tumor cells activity through modulation of Hes1 pathway
Ghanavati, R., Mohammadi, F., Javadi, A., Shahosseini, Z., Talebi, M., & Rohani, M. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100207 · Cited by 9
Microbiome and colorectal cancer: A review of the past, present, and future
Johns, M. S., & Petrelli, N. J. (2021) · Surgical Oncology · doi:10.1016/j.suronc.2021.101560 · Cited by 9
Meta-analysis reveals microbiome signatures for colorectal cancer that are universal across age groups and sequencing methods
Pekel, S., Karcher, N., Essex, M., Springer, F., Romano, S., Ducarmon, Q. R., Schudoma, C., Larralde, M., Lupatin, A., Zeißig, S., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.05.030 · Cited by 10
Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype–like Cluster
Chen, Y., Nakanishi, M., Bautista, E. J., Qendro, V., Sodergren, E. J., Rosenberg, D. W., & Weinstock, G. M. (2019) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-19-0273 · Cited by 8
Impact of black raspberries on the normal and malignant Apc deficient murine gut microbiome
May, S., McDermott, G., Marchesi, J. R., & Parry, L. (2019) · Journal of Berry Research · doi:10.3233/jbr-180372 · Cited by 8
Microbiome and Colorectal Cancer Management
Alrahawy, M., Javed, S., Atif, H., ElSanhoury, K., Mekhaeil, K., & Eskander, G. H. (2022) · Cureus · doi:10.7759/cureus.30720 · Cited by 8
The relationship between gut microbiota, lifestyle habits, and early-onset colorectal cancer: shedding light on early prediction
Deng, J.-W., Zhou, Y.-L., Zhang, Y., Zhou, C., & Fang, J. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03277-x · Cited by 9
Diagnostic value of fecal Fusobacterium nucleatum in colorectal cancer
Xing, C., Zhihao, L., & Di, J. (2023) · Archives of Medical Science · doi:10.5114/aoms/174261 · Cited by 7
Exploring Gut Microbiome Composition and Circulating Microbial DNA Fragments in Patients with Stage II/III Colorectal Cancer: A Comprehensive Analysis
Messaritakis, I., Koulouris, A., Boukla, E., Vogiatzoglou, K., Lagkouvardos, I., Intze, E., Sfakianaki, M., Chondrozoumaki, M., Karagianni, M., Athanasakis, E., et al. (2024) · Cancers · doi:10.3390/cancers16101923 · Cited by 7
Research progress on the correlation between intestinal flora and colorectal cancer
Wang, X., Zhang, Q., Xu, R., Li, X., & Hong, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1416806 · Cited by 7
Formulation and microbiological ancillary studies of gemifloxacin proniosomes for exploiting its role against LPS acute pneumonia model
El-Emam, G. A., El-Baz, A. M., Shata, A., Shaaban, A. A., El‐Sokkary, M. M. A., & Motawea, A. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.104053 · Cited by 7
Implementing precision medicine in endoscopy practice
Kuo, C., Wu, J., Yeh, J., Wang, W., Tu, C., Chiu, H., & Liao, W. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15933 · Cited by 7
Self-citation
Association of Fusobacterium nucleatum with colorectal cancer molecular subtypes and its outcome: a systematic review
Greco, L., Rubbino, F., Ferrari, C., Cameletti, M., Grizzi, F., Bonelli, F., Malesci, A., Mazzone, M., Ricciardiello, L., & Laghi, L. (2025) · Gut Microbiome · doi:10.1017/gmb.2025.3 · Cited by 7

Authors: Wong, S. H., Kwong, T. N. Y., Chow, T.-C., Luk, A. K. C., Dai, R. Z. W., Nakatsu, G., Lam, T. Y. T., Zhang, L., Wu, J. C. Y., Chan, F. K. L., Ng, S. S. M., Wong, M. C. S., Ng, S. C., Wu, W. K. K., Yu, J., & Sung, J. J. Y.
Affiliations: Chinese University of Hong Kong (HK)
Corresponding author: Sung, Joseph J Y
ORCID: Wong, Sunny H
Chow, Tai-Cheong
Nakatsu, Geicho
Lam, Thomas Y T
Zhang, Lin
Wu, Justin C Y
Chan, Francis K L
Ng, Simon S M
Wong, Martin C S
Ng, Siew C
Wu, William K K
Yu, Jun
Sung, Joseph J Y
Venue: Gut
Publisher: BMJ
Published: 2016-10-24
Volume: 66
Issue: 8
Pages: 1441-1448
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2016-312766
PMC: PMC5530471
OpenAlex: W2537258608
Cited by: 310
References: 32
Citations by year: 2026: 28 · 2025: 32 · 2024: 41 · 2023: 40 · 2022: 40 · 2021: 36 · 2020: 34 · 2019: 22 · 2018: 24 · 2017: 13
FWCI: 10.61
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Gut (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Croucher Foundation
Shenzhen Virtual University Park
National Key Research and Development Program of China (2013CB531401)
Topics: Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: Fusobacterium nucleatum, Peptostreptococcus anaerobius, Parvimonas micra, fecal immunochemical test, colorectal cancer, advanced adenoma, colorectal neoplasia detection, diagnostic sensitivity, non-invasive diagnosis
MeSH terms: Adenocarcinoma, Adenoma, DNA, Bacterial, Feces, Female, Humans, Male, Middle Aged, Occult Blood, Peptostreptococcus, ROC Curve, Biomarkers, Tumor, Colorectal Neoplasms, Fusobacterium nucleatum, Area Under Curve

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks