The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide
Open accessAbstract
Objective: Chronic obstructive pulmonary disease (COPD) is a global disease characterised by chronic obstruction of lung airflow interfering with normal breathing. Although the microbiota of respiratory tract is established to be associated with COPD, the causality of gut microbiota in COPD development is not yet established. We aimed to address the connection between gut microbiota composition and lung COPD development, and characterise bacteria and their derived active components for COPD amelioration. Design: A murine cigarette smoking (CS)-based model of COPD and strategies evaluating causal effects of microbiota were performed. Gut microbiota structure was analysed, followed by isolation of target bacterium. Single cell RNA sequencing, together with sera metabolomics analyses were performed to identify host responsive molecules. Bacteria derived active component was isolated, followed by functional assays. Results: Gut microbiota composition significantly affects CS-induced COPD development, and faecal microbiota transplantation restores COPD pathogenesis. A commensal bacterium Parabacteroides goldsteinii was isolated and shown to ameliorate COPD. Reduction of intestinal inflammation and enhancement of cellular mitochondrial and ribosomal activities in colon, systematic restoration of aberrant host amino acids metabolism in sera, and inhibition of lung inflammations act as the important COPD ameliorative mechanisms. Besides, the lipopolysaccharide derived from P. goldsteinii is anti-inflammatory, and significantly ameliorates COPD by acting as an antagonist of toll-like receptor 4 signalling pathway. Conclusion: The gut microbiota–lung COPD axis was connected. A potentially benefial bacterial strain and its functional component may be developed and used as alternative agents for COPD prevention or treatment.
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Cites
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
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Reciprocal interactions of the intestinal microbiota and immune system
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“6 7 The roles of microbiota in development of host health are emphasised, 8–10 some supporting the role of respiratory tract microbes towards the onset, progression, promotion and severity of COPD chronicity.”
BackgroundMicrobiota regulates immune defense against respiratory tract influenza A virus infection
Ichinohe, T., Pang, I. K., Kumamoto, Y., Peaper, D. R., Ho, J. H., Murray, T. S., & Iwasaki, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019378108 · Cited by 1,502
Lipid A Modification Systems in Gram-Negative Bacteria
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Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
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Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
Chang, C.-J., Lin, C.-S., Lu, C.-C., Martel, J., Ko, Y.-F., Ojcius, D. M., Tseng, S.-F., Wu, T.-R., Chen, Y.-Y. M., Young, J. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms8489 · Cited by 1,249
Self-citationMortality in COPD: role of comorbidities
Sin, D. D., Anthonisen, N. R., Soriano, J. B., & Agusti, A. G. (2006) · European Respiratory Journal · doi:10.1183/09031936.00133805 · Cited by 1,052
Chronic obstructive pulmonary disease
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Wu, T.-R., Lin, C.-S., Chang, C.-J., Lin, T.-L., Martel, J., Ko, Y.-F., Ojcius, D. M., Lu, C.-C., Young, J. D., & Lai, H.-C. (2019) · Gut · doi:10.1136/gutjnl-2017-315458 · Cited by 758
Self-citation
Cited by
Probiotic Development Strategy Centered on Stability and Regulatory Considerations
Kim, H., Haque, M. A., Razzak, M. A., Jang, M. J., Song, S., & Ku, S. (2026) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70320 · Cited by 43
Han, Y. J., Kim, S., Shin, H., Kim, H. W., & Park, J. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1451356 · Cited by 17
Sun, L., Zhang, Y., Dong, W., Sun, J., Wang, T., Shao, F., Dai, H., Han, J., Wang, W., Wang, S., et al. (2025) · iMeta · doi:10.1002/imt2.70066 · Cited by 15
Metadata
- Authors
- Lai, H.-C., Lin, T.-L., Chen, T.-W., Kuo, Y.-L., Chang, C.-J., Wu, T.-R., Shu, C.-C., Tsai, Y.-H., Swift, S., & Lu, C.-C.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2021-03-09
- Volume
- 71
- Issue
- 2
- Pages
- 309-321
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W3133880320
- Cited by
- 331
- References
- 54
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lai, H.-C., Lin, T.-L., Chen, T.-W., Kuo, Y.-L., Chang, C.-J., Wu, T.-R., Shu, C.-C., Tsai, Y.-H., Swift, S., & Lu, C.-C. (2022). Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide. Gut. https://doi.org/10.1136/gutjnl-2020-322599
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