The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Lipid A Modification Systems in Gram-Negative Bacteria
Open accessAbstract
The lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane of most gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic surface of the inner membrane by a conserved pathway of nine constitutive enzymes. Following attachment of the core oligosaccharide, nascent core-lipid A is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached. Diverse covalent modifications of the lipid A moiety may occur during its transit from the outer surface of the inner membrane to the outer membrane. Lipid A modification enzymes are reporters for lipopolysaccharide trafficking within the bacterial envelope. Modification systems are variable and often regulated by environmental conditions. Although not required for growth, the modification enzymes modulate virulence of some gram-negative pathogens. Heterologous expression of lipid A modification enzymes may enable the development of new vaccines.
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Cites
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Cited by
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Metadata
- Authors
- Raetz, C. R. H., Reynolds, C. M., Trent, M. S., & Bishop, R. E.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2007-06-07
- Volume
- 76
- Issue
- 1
- Pages
- 295-329
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2171780940
- Cited by
- 1,340
- References
- 10
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Raetz, C. R. H., Reynolds, C. M., Trent, M. S., & Bishop, R. E. (2007). Lipid A Modification Systems in Gram-Negative Bacteria. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.76.010307.145803
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
