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Cited by 128Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsGastrointestinal Bleeding Diagnosis and Treatment

Gastric per-oral endoscopic myotomy (G-POEM) for refractory gastroparesis: results from an international prospective trial

Vosoughi, Kia, Ichkhanian, Yervant, Benias, Petros, Miller, Larry, Aadam, A Aziz, Triggs, Joseph R, Law, Ryan, Hasler, William +11 more·2022·Gut
DOI 10.1136/gutjnl-2020-322756
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Abstract

Objective Although gastric per-oral endoscopic myotomy (G-POEM) is considered a promising technique for the management of refractory gastroparesis, high-quality evidence is limited. We prospectively investigated the efficacy and safety of G-POEM in unselected patients with refractory gastroparesis. Design In five tertiary centres, patients with symptomatic gastroparesis refractory to standard medical therapy and confirmed by impaired gastric emptying were included. The primary endpoint was clinical success, defined as at least one score decrease in Gastroparesis Cardinal Symptom Index (GCSI) with ≥25% decrease in two subscales, at 12 months. GCSI Score and subscales, adverse events (AEs) and 36-Item Short Form questionnaire of quality of life were evaluated at baseline and 1, 3, 6 and 12 months after G-POEM. Gastric emptying study was performed before and 3 months after the procedure. Results Of 80 enrolled patients, 75 patients (94%) completed 12-month follow-up. Clinical success at 12 months was 56% (95% CI, 44.8 to 66.7). GCSI Score (including subscales) improved moderately after G-POEM (p 2.6 (OR=3.23, p=0.04) and baseline gastric retention >20% at 4 hours (OR=3.65, p=0.03) were independent predictors of clinical success at 12 months, as was early response to G-POEM at 1 month after therapy (OR 8.75, p Conclusion G-POEM is a safe procedure, but showed only modest overall effectiveness in the treatment of refractory gastroparesis. Further studies are required to identify t…

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Crossref · 10.1136/gutjnl-2020-322756

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  • G‐POEM (gastric per‐oral endoscopic myotomy) reduces pyloric resistance and improves symptoms in refractory DGP, with success rates around 70% at 1 year in small series.

    “G‑POEM (gastric per‑oral endoscopic myotomy), which reduce pyloric resistance improve symptoms in refractory DGP, with success rates around 70% at 1 year in small series [129, 130];”

    From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [129]

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Authors
Vosoughi, K., Ichkhanian, Y., Benias, P., Miller, L., Aadam, A. A., Triggs, J. R., Law, R., Hasler, W., Bowers, N., Chaves, D., Ponte-Neto, A. M., Draganov, P., Yang, D., El Halabi, M., Sanaei, O., Brewer Gutierrez, O. I., Bulat, R. S., Pandolfino, J., & Khashab, M.
Affiliations
  • Johns Hopkins University (US)
  • Northwell Health (US)
  • Northwestern Medicine (US)
  • University of Michigan (US)
  • Universidade de São Paulo (BR)
  • Division of Gastroenterology and Hepatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil
  • University of Florida Health (US)
  • Department of Medicine, Mount Sinai Saint Luke's Hospital, New York, New York, USA
  • Division of Gastroenterology and Hepatology, Johns Hopkins Medicine, Baltimore, Maryland, USA
Corresponding author
Khashab, Mouen
ORCID
Venue
Gut
Publisher
BMJ
Published
2021-03-19
Volume
71
Issue
1
Pages
25-33
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gutjnl-2020-322756
OpenAlex
W3136542265
Cited by
128
References
5
Citations by year
2026: 14 · 2025: 24 · 2024: 22 · 2023: 25 · 2022: 31 · 2021: 11
FWCI
20.34
Type
journal article
Language
en
Open access
closed
Locations
  • Gut (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
Keywords
refractory gastroparesis, Gastroparesis Cardinal Symptom Index, gastric emptying, adverse events, quality of life, unselected patients
MeSH terms
Pyloromyotomy, Female, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Gastroparesis

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