Outcomes and Factors Associated With Reduced Symptoms in Patients With Gastroparesis
Open accessAbstract
Background & aims Gastroparesis is a chronic clinical syndrome characterized by delayed gastric emptying. However, little is known about patient outcomes or factors associated with reduction of symptoms. Methods We studied adult patients with gastroparesis (of diabetic or idiopathic type) enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium Gastroparesis Registry, seen every 16 weeks and treated according to the standard of care with prescribed medications or other therapies at 7 tertiary care centers. Characteristics associated with reduced symptoms, based on a decrease of 1 or more in the gastroparesis cardinal symptom index (GCSI) score after 48 weeks of care, were determined from logistic regression models. Data were collected from patients for up to 4 years (median, 2.1 y). Results Of 262 patients, 28% had reductions in GCSI scores of 1 or more at 48 weeks. However, there were no significant reductions in GCSI score from weeks 48 through 192. Factors independently associated with reduced symptoms at 48 weeks included male sex, age 50 years and older, initial infectious prodrome, antidepressant use, and 4-hour gastric retention greater than 20%. Factors associated with no reduction in symptoms included overweight or obesity, a history of smoking, use of pain modulators, moderate to severe abdominal pain, a severe gastroesophageal reflex, and moderate to severe depression. Conclusions Over a median follow-up period of 2.1 years, 28% of patients treated for gastroparesis at centers of expertise had reductions in GCSI scores of 1 or greater, regardless of diabetes. These findings indicate the chronic nature of gastroparesis. We identified factors associated with reduced symptoms that might be used to guide treatment. ClinicalTrials.gov no: NCT00398801.
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Changes in symptom intensity do not always parallel objective gastric emptying measurements.
“Moreover, changes in symptom intensity do not always parallel objective GE measurements, highlighting the complex interplay between pathophysiological derangements and central processing of visceral signals [14, 21–23].”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [21]
The Methods describe an objective gastric-emptying measurement, and the Results compare baseline gastric retention with symptom improvement at 48 weeks. Neither section reports whether changes in gastric emptying parallel changes in symptom intensity. Searches for repeat gastric-emptying measurements and correlations with symptom changes found no such comparison in our copy. (LLM, conf=0.75)
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“However as symptoms correlate poorly with emptying rates and gastric responses to prokinetics, this information may be less important [4, 37].”
Self-citationAbell, T. L., Yamada, G., McCallum, R. W., Natta, M. L. V., Tonascia, J. A., Parkman, H. P., Koch, K. L., Sarosiek, I., Farrugia, G., Grover, M., et al. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13714 · Cited by 55 · see citing works
Self-citationWhite Paper AGA: Gastroparesis: Clinical and Regulatory Insights for Clinical Trials
Pasricha, P. J., Camilleri, M., Hasler, W. L., & Parkman, H. P. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.04.011 · Cited by 46 · see citing works
Self-citationEndoFLIP and Pyloric Dilation for Gastroparesis Symptoms Refractory to Pyloromyotomy/Pyloroplasty
Jehangir, A., Malik, Z. A., Petrov, R. V., & Parkman, H. P. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06510-0 · Cited by 42 · see citing works
“GCSI score improvement ≥ 1 post-TTS dilation was considered clinically significant [27].”
BackgroundSelf-citationPasricha, P. J., Grover, M., Yates, K. P., Abell, T. L., Koch, K. L., McCallum, R. W., Sarosiek, I., Bernard, C. E., Kuo, B., Bulat, R., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.05.022 · Cited by 39 · see citing works
Self-citationDiabetic gastroparesis: current challenges and future prospects
Avalos, D. J., Sarosiek, I., Loganathan, P., & McCallum, R. W. (2018) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s131650 · Cited by 38 · see citing works
“117 Patients with mood disorders are more likely to report worse GP symptoms, 92,118 and clinical symptoms, such as abdominal pain and nausea/vomiting, have been linked with an overall poorer QoL.”
Self-citationFactors that contribute to the impairment of quality of life in gastroparesis
Parkman, H. P., Wilson, L., Yates, K. P., Koch, K. L., Abell, T. L., McCallum, R. W., Sarosiek, I., Kuo, B., Malik, Z. A., Schey, R., et al. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14087 · Cited by 37 · see citing works
Self-citationReflux Symptoms in Gastroparesis
Jehangir, A., & Parkman, H. P. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001190 · Cited by 36 · see citing works
“mild (1), mild (2), moderate (3), severe (4), and very severe (5).”
BackgroundSelf-citationZia, J. K., & Heitkemper, M. M. (2016) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.02.003 · Cited by 35 · see citing works
Pyloric Therapies for Gastroparesis
Ahuja, N., & Clarke, J. (2017) · Current treatment options in gastroenterology · doi:10.1007/s11938-017-0124-4 · Cited by 28 · see citing works
Self-citationGastroparesis in Non-Diabetics: Associated Conditions and Possible Risk Factors
Nassar, Y., & Richter, S. J. (2018) · Gastroenterology Research · doi:10.14740/gr1060w · Cited by 35 · see citing works
Watts, L. S., Baker, J. R., Lee, A. A., Harer, K. N., Bowers, N., Law, R. J., & Hasler, W. L. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13892 · Cited by 34 · see citing works
Self-citationDiabetic Gastroparesis and Nondiabetic Gastroparesis
Shen, S., Xu, J., Lamm, V., Vachaparambil, C. T., Chen, H., & Cai, Q. (2018) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2018.08.002 · Cited by 34 · see citing works
Schol, J., Huang, I.-H., Carbone, F., Fernandez, L. M. B., Gourcerol, G., Ho, V., Kohn, G., Lacy, B. E., Colombo, A. L., Miwa, H., et al. (2025) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(24)00284-x · Cited by 32 · see citing works
Self-citationPathophysiology of idiopathic gastroparesis and implications for therapy
Bekkelund, M., Sangnes, D. A., Hatlebakk, J. G., & Aabakken, L. (2019) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2018.1558280 · Cited by 34 · see citing works
“In a prospective study of 262 gastroparesis patients (177 idiopathic), only one-third responded with a modest symptomatic improvement after 48 weeks of standard care, which included medications (anti-emetics, prokinetics, proton pump inhibitors), total parenteral nutrition in 26 patients and gastric electrical stimula…”
BackgroundShin, A. (2024) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(24)00231-0 · Cited by 30 · see citing works
Rajan, E., Gostout, C. J., Song, L. M. W. K., Szarka, L. A., Kashyap, P., Smyrk, T. C., Bingener, J., Deters, J. L., Knipschield, M. A., Bernard, C. E., et al. (2016) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2016.04.029 · Cited by 30 · see citing works
Self-citationParkman, H., Yates, K. P., Sarosiek, I., Bulat, R. S., Abell, T., Koch, K., Kuo, B., Grover, M., Farrugia, G., Silver, P., et al. (2023) · Alimentary Pharmacology and Therapeutics · doi:10.1111/apt.17479 · Cited by 27 · see citing works
“Women, N (%) 43 (91) 45 (92) 88 (92) Hispanic, N (%) 13 (28) 17 (35) 30 (31) Race, N (%) White 43 (91) 41 (85) 84 (88) Black 2 (4) 5 (10) 7 (7) Otherb 2 (4) 2 (4) 4 (4) Married, N (%) 16 (34) 21 (43) 37 (39) Diabetes type 1 or type 2, N (%) 16 (34) 21 (43) 37 (39) Diabetes type 1 3 (6) 6 (12) 9 (9) Diabetes type 2 13…”
Self-citationChildhood gastroparesis is a unique entity in need of further investigation
Febo‐Rodriguez, L., Chumpitazi, B. P., & Shulman, R. J. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13699 · Cited by 29 · see citing works
Sato, H., & Grover, M. (2022) · Gastro Hep Advances · doi:10.1016/j.gastha.2022.10.005 · Cited by 26 · see citing works
“92 Overweight status, a history of smoking, use of pain modulators, moderate to severe abdominal pain, a severe gastroesophageal re fl ex, and depression are reported to be the risk factors for long-term persistence of symptoms.”
BackgroundBody weight in patients with idiopathic gastroparesis
Parkman, H. P., Natta, M. L. V., Yamada, G., Grover, M., McCallum, R. W., Sarosiek, I., Farrugia, G., Koch, K. L., Abell, T. L., Kuo, B., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13974 · Cited by 26 · see citing works
“48-week change in scintigraphy N 22 58 30 2-hr solid retention - % −8 (30) −15 (24) −20 (25) .”
Self-citationStrijbos, D., Keszthelyi, D., Smeets, F. G. M., Kruimel, J. W., Gilissen, L. P. L., de Ridder, R. J. J., Conchillo, J. M., & Masclee, A. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13588 · Cited by 26 · see citing works
Botulinum Toxin A Improves Symptoms of Gastroparesis
Reichenbach, Z. W., Stanek, S., Patel, S., Ward, S. J., Malik, Z. A., Parkman, H. P., & Schey, R. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05885-z · Cited by 27 · see citing works
“As described in Pasricha 2015, a decrease of ≥ 1 point on the GCSI correlated with improvement [23].”
BackgroundSelf-citationGastric Electrical Stimulation for Gastroparesis and Chronic Unexplained Nausea and Vomiting
Wo, J. M., Nowak, T. V., Waseem, S., & Ward, M. P. (2016) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-016-0103-1 · Cited by 24 · see citing works
Frequency of hospital readmission and care fragmentation in gastroparesis: A nationwide analysis
Qayed, E. S., & Muftah, M. (2018) · World Journal of Gastrointestinal Endoscopy · doi:10.4253/wjge.v10.i9.200 · Cited by 24 · see citing works
Hybrid Closed-loop to Manage Gastroparesis in People With Type 1 Diabetes: a Case Series
Daly, A., Hartnell, S., Boughton, C. K., & Evans, M. (2021) · Journal of Diabetes Science and Technology · doi:10.1177/19322968211035447 · Cited by 23 · see citing works
2023 update on the clinical management of gastroparesis
Halabi, M. E., & Parkman, H. P. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2196404 · Cited by 24 · see citing works
Self-citationVarghese, C., Lim, A. H., Daker, C., Sebaratnam, G., Gharibans, A., Andrews, C., Hasler, W. L., & O'Grady, G. (2024) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003213 · Cited by 19 · see citing works
“Fewer than a third of patients respond to standard of care treatment (including medications and lifestyle modi fi cation) (10), and response to prokinetics is frequently suboptimal (11).”
Self-citationYu, T., Zheng, Y., Wang, Y., Xiong, W., & Lin, L. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.12.002 · Cited by 19 · see citing works
Methodologic considerations for studies of chronic nausea and vomiting in adults and children
Hasler, W. L., Li, B. U. K., Koch, K. L., Parkman, H. P., Kovacic, K. K., & McCallum, R. W. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.08.001 · Cited by 19 · see citing works
Self-citationThe willingness of patients with gastroparesis to take risks with medications
Navas, C. M., Crowell, M. D., & Lacy, B. E. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15112 · Cited by 19 · see citing works
“Gastroparesis is a clinically challenging disorder to treat as options are limited and the majority of gastroparesis patients show little, if any substantial improvement in symptoms over time.(13) At present, metoclopramide is the only medication approved by the US Food and Drug Administration for the treatment of gas…”
BackgroundGourcerol, G., Gonzalez, J., Bonaz, B. L., Fontaine, S., Zerbib, F., Mion, F., Basile, P., Gillibert, A., Labonde, A., Soliman, H., et al. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14565 · Cited by 18 · see citing works
Imaging in Gastroparesis: Exploring Innovative Diagnostic Approaches, Symptoms, and Treatment
Mandarino, F. V., Testoni, S. G. G., Barchi, A., Azzolini, F., Sinagra, E., Pepe, G., Chiti, A., & Danese, S. (2023) · Life · doi:10.3390/life13081743 · Cited by 18 · see citing works
“GP is a chronic and unremitting disease, with only 28% of cases showing improvement in symptoms [37].”
BackgroundEvaluation of the safety profile of endoscopic pyloromyotomy by G-POEM: a French multicenter study
Baret, F., Jacques, J., Pioche, M., Albouys, J., Vitton, V., Vanbiervliet, G., Debourdeau, A., Barthet, M. A., & Gonzalez, J. (2022) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848221122472 · Cited by 16 · see citing works
Novel insights into the effects of diabetes on gastric motility
Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2016.1129898 · Cited by 16 · see citing works
“with a 50% reduction in the probability of symptom improvement, whereas anti-depressant use improved the odds almost twofold over a 48 week period.[38] It may be difficult to discriminate between functional”
BackgroundEndoscopic Therapies for Gastroparesis
Su, A., Conklin, J. L., & Sedarat, A. (2018) · Current Gastroenterology Reports · doi:10.1007/s11894-018-0630-0 · Cited by 15 · see citing works
Thoracic Spinal Nerve Neuromodulation Therapy for Diabetic Gastroparesis: A Proof-of-Concept Study
Karunaratne, T. B., Yan, Y., Eubanks, A., Inman, B., Rao, S. S. C., & Sharma, A. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.09.012 · Cited by 14 · see citing works
A Critical Review of the Current Clinical Landscape of Gastroparesis.
Fosso, C., & Quigley, E. M. M. (2018) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
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Ichkhanian, Y., Al‐Haddad, M., Jacobs, C. C., Schlachterman, A., Yang, J. F., Canakis, A., Kim, R. E., Guerson-Gil, A., D'Souza, L. S., Alsheik, E. H., et al. (2023) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2023.04.2079 · Cited by 14 · see citing works
Upper GI Disorders: Pathophysiology and Current Therapeutic Approaches.
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“The outcome of gastroparesis patients was assessed in the NIH Gastroparesis Consortium in patients with either diabetic or idiopathic gastroparesis (Pasricha et al. 2015).”
BackgroundSelf-citationJehangir, A., Collier, A., Shakhatreh, M., Malik, Z., & Parkman, H. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05723-2 · Cited by 13 · see citing works
Self-citationMenopause and gastrointestinal health and disease
Ley, D., & Saha, S. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01075-7 · Cited by 13 · see citing works
“Male sex was found to be an independent predictor of symptom improvement at 48 weeks and was associated with over two times the rate of improvement when compared with female sex 72 .”
Investigational drug therapies for the treatment of gastroparesis
Sanger, G. J., & Pasricha, P. J. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1288214 · Cited by 13 · see citing works
“patients showed improvement, regardless of diabetes [4].”
BackgroundSelf-citationCamilleri, M., & Szarka, L. A. (2016) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2016.07.012 · Cited by 12 · see citing works
Electroceuticals and Magnetoceuticals in Gastroenterology
Song, G., Sclocco, R., Sharma, A., Guerrero-López, I., & Kuo, B. (2024) · Biomolecules · doi:10.3390/biom14070760 · Cited by 11 · see citing works
“Despite expert management, only 28% of patients had a significant reduction in their symptom scores [53].”
BackgroundIchkhanian, Y., Hwang, J. H., Ofosu, A., Li, A. A., Szvarca, D., Draganov, P. V., Yang, D. J., Alsheik, E. H., Zuchelli, T. E., Piraka, C. R., et al. (2022) · Endoscopy International Open · doi:10.1055/a-1797-9587 · Cited by 10 · see citing works
“GER, in turn, was found to be independently associated with the development of bronchiolitis obliterans syndrome (BOS), the leading cause of primary graft failure and mortality in LTx patients [5, 10].”
Gold-Smith, F. D., Singh, R. G., & Petrov, M. S. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0859-7168 · Cited by 10 · see citing works
Dimino, J., & Kuo, B. (2025) · Diagnostics · doi:10.3390/diagnostics15070935 · Cited by 9 · see citing works
“%) did not report clinically meaningful symptomatic improvement over 48 weeks to 4 years of follow-up [11].”
Noar, M. D., & Khan, S. (2022) · Surgical Endoscopy · doi:10.1007/s00464-022-09642-8 · Cited by 9 · see citing works
Lee, A. A., Rao, K. K., Parkman, H. P., McCallum, R. W., Sarosiek, I., Nguyen, L. A. B., Wo, J. M., Schulman, M. I., Moshiree, B., Rao, S. S. C., et al. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.09.032 · Cited by 9 · see citing works
Self-citationFebo‐Rodriguez, L., Chumpitazi, B. P., Musaad, S. M. A., Sher, A. C., & Shulman, R. J. (2020) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2020.12.048 · Cited by 8 · see citing works
A global bibliometric and visualized analysis of the status and trends of gastroparesis research
Li, M., Gao, N., Wang, S.-L., Guo, Y., & Liu, Z. (2023) · European journal of medical research · doi:10.1186/s40001-023-01537-1 · Cited by 7 · see citing works
“Medication is often slow to take effect, with one-third of patients showing no improvement until 1 year after the intervention [81].”
BackgroundThe role of diet in diabetes gastroparesis treatment: a systematic review and meta-analysis
Lin, D., Wang, H., Ou, Y., Li, L., Zhang, Q., Yan, J., Peng, D., & Peng, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1379398 · Cited by 7 · see citing works
Gastroparesis: Time for a Reappraisal?
Tack, J. F., & Wald, A. M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.10.029 · Cited by 7 · see citing works
“Paradoxically, more severely delayed gastric emptying was associated with a greater likelihood of improvement, but there were no differences in outcome between diabetic or idiopathic gastroparesis patients at 48 weeks.(14) The finding that patients with coexisting depression, anxiety (as a proxy for anxiolytic use), a…”
BackgroundInfluentialPost-pancreatitis diabetes mellitus: towards understanding the role of gastrointestinal motility
Gold-Smith, F. D., Chand, S. K., & Petrov, M. S. (2018) · Minerva Gastroenterologica e Dietologica · doi:10.23736/s1121-421x.18.02507-2 · Cited by 7 · see citing works
Diabetic Gastroparesis and its Emerging Therapeutic Options: A Narrative Review of the Literature
Zahid, S. A., Tated, R. C. P., Mathew, M., Rajkumar, D., Karnik, S. B., Roy, A. P., Jacob, F. P., Salian, R. B., Razzaq, W., Shivakumar, D., et al. (2023) · Cureus · doi:10.7759/cureus.44870 · Cited by 7 · see citing works
Endoscopic findings do not predict per-oral pyloromyotomy (POP) response
Schwalbe, K., Finelli, C., Moon, S., Niehaus, H., Kondajji, A., Tu, C., Fathalizadeh, A., Kroh, M., & Allemang, M. T. (2022) · Surgical Endoscopy · doi:10.1007/s00464-022-09321-8 · Cited by 6 · see citing works
Wolfson, S. M., Wilhelm, Z. R., Opekun, A. R., Orth, R. C., Shulman, R. J., & Chumpitazi, B. P. (2021) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003089 · Cited by 6 · see citing works
“3% with complete symptom resolution) appears to be better than that in adults followed at quaternary care centers, in which only 28% of adults showed any sign of symptomatic improvement (32).”
BackgroundPatient factors influence surgical options in gastroparesis
Thompson, J. S., Hewlett, A. T., Lyden, E. R., Scott, J. R., & McBride, C. L. (2020) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2020.02.022 · Cited by 6 · see citing works
Therapies for diabetic gastroparesis
Wang, S., Wang, R., Zhang, Y., Zhang, X., Cai, B., Lu, Y., Xia, Y., & Chen, Q. (2020) · Medicine · doi:10.1097/md.0000000000020461 · Cited by 6 · see citing works
Opioids in Gastroparesis: Bystander or Cause?
Pannemans, J., Carbone, F., & Tack, J. F. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.08.040 · Cited by 6 · see citing works
Takakura, W., Surjanhata, B. C., Nguyen, L. A. B., Parkman, H. P., Rao, S. S. C., McCallum, R. W., Schulman, M. I., Wo, J. M., Sarosiek, I., Moshiree, B., et al. (2024) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000743 · Cited by 5 · see citing works
“Although Pasricha et al. employed cross-validation to estimate performance of their predictive model, the lack of an independent validation data set may have over-estimated their model performance (34).”
InfluentialSelf-citationGlass half empty? Lessons learned about gastroparesis
McKenzie, P., & Bielefeldt, K. (2018) · F1000Research · doi:10.12688/f1000research.14043.1 · Cited by 5 · see citing works
Saleem, S., Hussain, A., Alsamman, M. A., Inayat, F., Kaler, J., Tansel, A., & Thomas, A. L. (2021) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_673_20 · Cited by 5 · see citing works
The goals for successful development of treatment in gastroparesis
Yang, D. Y., & Camilleri, M. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14849 · Cited by 5 · see citing works
Toward a Better Drug for Gastroparesis: The Problem With a Moving Target
Pasricha, P. J., & Snape, W. J. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.019 · Cited by 5 · see citing works
“1 Gastroparesis, a disorder defined by delayed gastric emptying, and characterized by nausea, vomiting and other chronic debilitating symptoms that improves little over time, remains one of the most challenging gastroenterological conditions to treat.(1) With increasing recognition of the size of the market and the la…”
BackgroundSelf-citationSilva, L. G. R., Cunha, D. N., Ferreira, I. N., Vargas, J. R., Lopes, J. R., Saraiva, N. B., Campos, V. D. A. R., Thomaz, Y. B., & Leite, N. A. A. (2022) · Brazilian Journal of Health Review · doi:10.34119/bjhrv5n2-348 · Cited by 4 · see citing works
Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light
Zipf, D., Vogt, M., Sathyanarayanan, U., Wagdi, A., Riebeling, J., Patejdl, R., & Bruegmann, T. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.70028 · Cited by 4 · see citing works
Nausea and Vomiting Related to Esophagus and Stomach Diseases
Koch, K. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-34076-0_3 · Cited by 4 · see citing works
Self-citationDurcan, R., Donaghy, P. C., Barnett, N. A., Olsen, K., Yarnall, A. J., Taylor, J., McKeith, I. G., O'Brien, J. T., & Thomas, A. J. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5100 · Cited by 4 · see citing works
“A number of factors have independent of LB disease have been associated with reduced gastroparesis symptoms including; male sex, age greater than 50 years, and concomitant medication use such gastric acid suppressing agents and antidepressant use.(25) We do not believe any of these factors contributed to the low rates…”
BackgroundGender Differences in Gastroparesis
Kassamali, F., & Lin, M. S. (2023) · Foregut The Journal of the American Foregut Society · doi:10.1177/26345161231160723 · Cited by 4 · see citing works
Reconsideration of the Gastroparetic Syndrome
Gilbert, R., Siamwala, J. H., Kumar, V., Thompson, C. C., & Shikora, S. A. (2023) · Current Gastroenterology Reports · doi:10.1007/s11894-023-00865-w · Cited by 4 · see citing works
Rayner, C. K., Jones, K. L., & Horowitz, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818586-5.00018-1 · Cited by 4 · see citing works
Wifi, M.-N., El-Sherbiny, M., Mohamed, R. S., Kandeel, A., & Rizk, S. E. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03977-x · Cited by 3 · see citing works
“This 4 The correlations between Age, HbA1c reduction (%), initial total GCSI and response to medical treatment (≥ 50 years) was associated with the best outcome, with an odds ratio for improvement of 3.35 (CI:1.62–6.91, p = 0.001) [24].”
InfluentialAbraham, R., Foong, D., & Ho, V. (2025) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm25094 · Cited by 3 · see citing works
“7,9 Our findings further support the idea that while GES provides essential information on emptying, it is often insufficient on its own to fully inform clinical management.”
InfluentialWang, X. J., O'Connor, M. C., Peck, T., Johnston, G., & Prichard, D. O. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14819 · Cited by 3 · see citing works
“4,39 Indeed, many patients with upper gastrointestinal symptoms have dysfunction of multiple sensorimotor facets.”
Clinical predictors of symptom improvement failure in gastroparesis
Amjad, W. (2022) · Annals of Gastroenterology · doi:10.20524/aog.2022.0696 · Cited by 3 · see citing works
“Our study was unable to reproduce the predictors of a poor outcome, including obesity, smoking and depression, established by a previous prospective large multicenter study over a longer period [5].”
ResultTrends in Gastroparesis Management
Tanner, S. E., Kurin, M., Shahsavari, D., Malik, Z. A., & Parkman, H. P. (2022) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001766 · Cited by 3 · see citing works
Self-citationGastroparesis for the nongastroenterologist
Araujo-Duran, J., Chatterjee, A., & Garg, S. (2024) · Cleveland Clinic journal of medicine · doi:10.3949/ccjm.91a.23078 · Cited by 3 · see citing works
“18,19 Gastroparesis is associated with increased emergency department visits and hospitalizations due to exacerbation of symptoms such as vomiting, electrolyte abnormalities, abdominal pain, and malnutrition.”
BackgroundChartier, M., Duboc, H., Moszkowicz, D., Dior, M., le Gall, M., Coffin, B., & Soliman, H. (2024) · Clinics And Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2024.102481 · Cited by 3 · see citing works
Targeting Treatment of Gastroparesis
Hasler, W. L. (2020) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2020.04.007 · Cited by 3 · see citing works
Self-citation
- Authors
- Pasricha, P. J., Yates, K. P., Nguyen, L., Clarke, J., Abell, T. L., Farrugia, G., Hasler, W. L., Koch, K. L., Snape, W. J., McCallum, R. W., Sarosiek, I., Tonascia, J., Miriel, L. A., Lee, L., Hamilton, F., & Parkman, H. P.
- Affiliations
- Johns Hopkins University (US)
- Stanford University (US)
- University of Louisville (US)
- Mayo Clinic (US)
- University of Michigan (US)
- Wake Forest University Health Sciences (US)
- California Pacific Medical Center (US)
- Texas Tech University (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Temple University (US)
- Corresponding author
- Pasricha, Pankaj J.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 149
- Issue
- 7
- Pages
- 1762-1774.e4
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC4663150
- OpenAlex
- W1188512702
- Cited by
- 143
- References
- 60
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 12 · 2021: 13 · 2020: 18 · 2019: 18 · 2018: 14 · 2017: 9 · 2016: 11 · 2015: 3
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Association of Schools of Public Health (2007-2010, 2009-2011, 2009-2012)
- Johns Hopkins University
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- gastroparesis, delayed gastric emptying, symptom improvement, Gastroparesis Cardinal Symptom Index, diabetic gastroparesis, idiopathic gastroparesis, gastric retention, abdominal pain, depression, obesity, smoking, antidepressants, gastroesophageal reflux, treatment outcomes
- MeSH terms
- Adult, Age Factors, Female, Gastric Emptying, Humans, Life Style, Male, Middle Aged, Predictive Value of Tests, Registries, Remission Induction, Risk Factors, Severity of Illness Index, Sex Factors, Time Factors, United States, Comorbidity, Linear Models, Logistic Models, Odds Ratio, Treatment Outcome, Gastroparesis, Recovery of Function
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