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Population prevalence, incidence, and predictors of atrial fibrillation in the Renfrew/Paisley study
Open accessAbstract
OBJECTIVES: Though atrial fibrillation (AF) is an important cause of cardiovascular morbidity, there are few large epidemiological studies of its prevalence, incidence, and risk factors. The epidemiological features of AF are described in one of the largest population cohorts ever studied. METHODS: The prevalence and incidence of AF were studied in the Renfrew/Paisley population cohort of 15 406 men and women aged 45–64 years living in the west of Scotland. This cohort was initially screened between 1972 and 1976 and again between 1977 and 1979. Incident hospitalisations with AF in the 20 year period following initial screening were also studied. RESULTS: The population prevalence of AF in this cohort was 6.5 cases/1000 examinations. Prevalence was higher in men and older subjects. In those who were rescreened, the four year incidence of AF was 0.54 cases/1000 person years. Radiological cardiomegaly was the most powerful predictor of new AF (adjusted odds ratio 14.0). During 20 year follow up, 3.5% of this cohort was discharged from hospital with a diagnosis of AF; the rate of incident hospitalisation for AF was 1.9 cases/1000 person years. Radiological cardiomegaly (adjusted odds ratio 1.46) and systolic blood pressure (adjusted odds ratio 2.1 for ⩾ 169 mm Hg) were independent predictors of this outcome. CONCLUSIONS: Data from one of the largest epidemiological studies ever undertaken confirm that AF has a large population prevalence and incidence, even in middle aged people. More important, it was shown that the long term incidence of hospitalisation related to AF is high and that two simple clinical measurements are highly predictive of incident AF. These findings have important implications for the prevention of AF.
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“Several regional studies suggest rising prevalence and incidence of AF.9–13”
From Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study (2014) · cites this paper as [11]
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Metadata
- Authors
- Stewart, S., Hart, C. L., Hole, D. J., & McMurray, J. J. V.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- McMurray, J J V
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2001-11-01
- Volume
- 86
- Issue
- 5
- Pages
- 516-521
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- PMC
- PMC1729985
- OpenAlex
- W2139693734
- Cited by
- 661
- References
- 24
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 13 · 2023: 19 · 2022: 14 · 2021: 16 · 2020: 17 · 2019: 32 · 2018: 21 · 2017: 37 · 2016: 59 · 2015: 61 · 2014: 61 · 2013: 66 · 2012: 50
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, prevalence, incidence, risk factors, systolic blood pressure, hospitalization, middle-aged adults, atrial fibrillation prevention
- MeSH terms
- Atrial Fibrillation, Female, Hospitalization, Humans, Male, Middle Aged, Scotland, Cohort Studies, Incidence, Prevalence, Logistic Models, Age Distribution, Sex Distribution
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