Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study)
Abstract
Atrial fibrillation (AF) is a common arrhythmia in elderly persons and a common cause of embolic stroke. Most studies of the prevalence and correlates of AF have used selected, hospital-based populations. The Cardiovascular Health Study is a population-based, longitudinal study of risk factors for coronary artery disease and stroke in 5,201 men and women aged > or = 65 years. AF was diagnosed in 4.8% of women and in 6.2% of men at the baseline examination, and prevalence was strongly associated with advanced age in women. Prevalence of AF was 9.1% in men and women with clinical cardiovascular disease, 4.6% in patients with evidence of subclinical but no clinical cardiovascular disease, and only 1.6% in subjects with neither clinical nor subclinical cardiovascular disease. A history of congestive heart failure, valvular heart disease and stroke, echocardiographic evidence of enlarged left atrial dimension, abnormal mitral or aortic valve function, treated systemic hypertension, and advanced age were independently associated with the prevalence of AF. The low prevalence of AF in the absence of clinical and subclinical cardiovascular disease calls into question the existence and clinical usefulness of the concept of so-called "lone atrial fibrillation" in the elderly.
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Valvular heart disease is independently associated with incident AF.
“Valvular heart disease is independently associated with incident AF.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [252]
Atrial fibrillation is a heterogeneous condition, and in a subset of individuals can be asymptomatic.
“AF is a heterogeneous condition, and in a subset of individuals can be asymptomatic.35, 36”
From Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study (2014) · cites this paper as [35]
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- Authors
- Furberg, C. D., Psaty, B. M., Manolio, T. A., Gardin, J. M., Smith, V. E., & Rautaharju, P. M.
- Affiliations
- Atrium Health Wake Forest Baptist (US)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1994-08
- Volume
- 74
- Issue
- 3
- Pages
- 236-241
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2029045834
- Cited by
- 1,096
- References
- 28
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 10 · 2023: 16 · 2022: 26 · 2021: 26 · 2020: 27 · 2019: 24 · 2018: 30 · 2017: 34 · 2016: 40 · 2015: 42 · 2014: 57 · 2013: 56 · 2012: 58
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc085081-021, n01hc085079-024, n01hc085080-026)
- National Heart, Lung, and Blood Institute (N01-HC-85081, N01HC85080, N01-HC85079)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, prevalence, older adults, Cardiovascular Health Study, cardiovascular disease, subclinical cardiovascular disease, congestive heart failure, valvular heart disease, stroke, left atrial enlargement, systemic hypertension, age differences, lone atrial fibrillation
- MeSH terms
- Aged, Aged, 80 and over, Anti-Arrhythmia Agents, Anticoagulants, Atrial Fibrillation, Blood Glucose, Cardiovascular Diseases, Coronary Disease, Electrocardiography, Female, Humans, Male, Regression Analysis, Sampling Studies, Prevalence, Chi-Square Distribution
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