The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The influence of age, sex and other variables on the plasma level of N-terminal pro brain natriuretic peptide in a large sample of the general population
Open accessAbstract
Objective: To identify potentially confounding variables for the interpretation of plasma N-terminal pro brain natriuretic peptide (NT-proBNP). Design: Randomly selected subjects filled in a heart failure questionnaire and underwent pulse and blood pressure measurements, ECG, echocardiography, and blood sampling. Setting: Subjects were recruited from four Copenhagen general practices located in the same urban area and were examined in a Copenhagen University Hospital. Patients: 382 women and 290 men in four age groups: 50–59 years (n = 174); 60–69 years (n = 204); 70–79 years (n = 174); and > 80 years (n = 120). Main outcome measures: Associations between the plasma concentration of NT-proBNP and a range of clinical variables. Results: In the undivided study sample, female sex (p < 0.0001), greater age (p < 0.0001), increasing dyspnoea (p = 0.0001), diabetes mellitus (p = 0.01), valvar heart disease (p = 0.002), low heart rate (p < 0.0001), left ventricular ejection fraction ⩽ 45% (p < 0.0001), abnormal ECG (p < 0.0001), high log 10[plasma creatinine] (p = 0.0009), low log 10[plasma glycosylated haemoglobin A1c] (p = 0.0004), and high log 10[urine albumin] (p < 0.0001) were independently associated with a high plasma log 10[plasma NT-proBNP] by multiple linear regression analysis. Conclusions: A single reference interval for the normal value of NT-proBNP is unlikely to suffice. There are several confounders for the interpretation of a given NT-proBNP concentration and at the very least adjustment should be made for the independent effects of age and sex.
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Cites
Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
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Guidelines for the diagnosis and treatment of chronic heart failure
Remme, W. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2783 · Cited by 1,592
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Plasma brain natriuretic peptide in assessment of acute dyspnoea
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Cited by
The N-terminal Pro-BNP Investigation of Dyspnea in the Emergency department (PRIDE) study
Januzzi, J. L., Camargo, C. A., Anwaruddin, S., Baggish, A. L., Chen, A. A., Krauser, D. G., Tung, R., Cameron, R., Nagurney, J. T., Chae, C. U., et al. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.12.032 · Cited by 1,207
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Diabetes, left ventricular systolic dysfunction, and chronic heart failure
MacDonald, M. R., Petrie, M. C., Hawkins, N. M., Petrie, J. R., Fisher, M., McKelvie, R., Aguilar, D., Krum, H., & McMurray, J. J. V. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn156 · Cited by 227
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Self-citation
Metadata
- Authors
- Raymond, I., Groenning, B. A., Hildebrandt, P. R., Nilsson, J. C., Baumann, M., Trawinski, J., & Pedersen, F.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2003-07
- Volume
- 89
- Issue
- 7
- Pages
- 745-751
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W2153845023
- Cited by
- 351
- References
- 23
- FWCI
- 15.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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