Diabetes, left ventricular systolic dysfunction, and chronic heart failure
Abstract
Chronic heart failure (HF) and diabetes mellitus (DM) commonly coexist. Each condition increases the likelihood of developing the other, and when they occur together in the same patient the risk of morbidity and mortality increases markedly. We discuss the epidemiological overlap and consider the complex patho-physiological pathways linking the two diseases. The treatment of each condition is made more problematic by the presence of the other. We review the evidence-based treatment strategies and discuss the common problems faced by physicians when treating patients with both conditions. This article forms a comprehensive overview of a fascinating intersection between two common diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HFrEF is an independent predictor of fatal and non-fatal clinical outcomes in patients with T2DM.
“Conversely, HFrEF is an independent predictor of fatal and non-fatal clinical outcomes in patients with T2DM.2,3”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [2]
Previous concerns that metformin may cause metabolic acidosis are no longer justified.
“Previous concerns that metformin may cause metabolic acidosis are no longer justified.2”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [2]
In large observational studies, insulin is associated with higher mortality rates than metformin.
“In large observational studies, insulin is associated with higher mortality rates than metformin.2”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [2]
In large observational studies, metformin was associated with lower mortality and HF hospitalization rates than other T2DM drugs (primarily insulin and sulphonylureas).
“This was based on large observational studies where metformin was associated with lower mortality and HF hospitalization rates than other T2DM drugs (primarily insulin and sulphonylureas). 2”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [2]
Sulphonylureas have also been associated with higher death rates than metformin.
“There have been similar concerns with sulphonylureas which, as insulin secretagogues, have also been associated with higher death rates than metformin.2”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [2]
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Stratton, I. M. (2000) · BMJ · doi:10.1136/bmj.321.7258.405 · Cited by 9,059 · see citing works
Turner, R. C., Fox, C., Matthews, McElroy, H. H., Cull, C. A., Holman, R. R., Neil, P., Hadden, D. R., Wright, D., Manley, E., et al. (1998) · The Lancet · Cited by 8,419 · see citing works
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493 · cited 1× · see citing works
“In RENAAL, 1513 diabetics with nephropathy were randomized to losartan 50–100 mg or placebo.(60) There was a 32% reduction in the risk of first HF hospitalization with losartan (P 1⁄4 0.”
BackgroundAmiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure
Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Packer, D. L., Boineau, R., Domanski, M., Troutman, C., Anderson, J., Johnson, G., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043399 · Cited by 6,552 · see citing works
Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407 · see citing works
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
(2005) · New England Journal of Medicine · doi:10.1056/nejmoa052187 · Cited by 5,138 · see citing works
The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial
Lechat, P. P., Brunhuber, K., Hofmann, R., Kuhn, P., Nesser, H., Slany, J., Weihs, W., Wiedermann, C. J., Wimmer, H., van Mieghem, W., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11181-9 · Cited by 4,922 · see citing works
Stearne, M. R., Palmer, S. L., Hammersley, M. S., Franklin, S. L., Spivey, R. S., Lévy, J., Tidy, C. R., Bell, N. J., Steemson, J., Barrow, B. A., et al. (1998) · UCL Discovery (University College London) · Cited by 4,803 · see citing works
Dormandy, J. A., Charbonnel, B., Eckland, D. J., Erdmann, E., Massi-Benedetti, M., Moules, I. K., Skene, A. M., Tan, M. H., Lefèbvre, P. J., Murray, G. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67528-9 · Cited by 4,129 · see citing works
Colhoun, H. M., Betteridge, D. J., Durrington, P. N., Hitman, G. A., W Neil, H. A., Livingstone, S. J., Thomason, M. J., Mackness, M. I., Charlton-Menys, V., & Fuller, J. H. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16895-5 · Cited by 3,755 · see citing works
A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure
Cohn, J. N., & Tognoni, G. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010713 · Cited by 3,108 · see citing works
Effect of carvedilol on survival in severe chronic heart failure
Packer, M., Coats, A. J. S., Fowler, M. B., Katus, H. A., Krum, H., Mohacsi, P., Rouleau, J. L., Tendera, M., Castaigne, A., Roecker, E. B., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442201 · Cited by 3,093 · see citing works
Self-citationThe effect of digoxin on mortality and morbidity in patients with heart failure
(1997) · New England Journal of Medicine · doi:10.1056/nejm199702203360801 · Cited by 3,016 · see citing works
Burden of Systolic and Diastolic Ventricular Dysfunction in the Community
Redfield, M. M., Jacobsen, S. J., Burnett, J. C. J., Mahoney, D. W., Bailey, K. R., & Rodeheffer, R. J. (2003) · JAMA · doi:10.1001/jama.289.2.194 · Cited by 2,989 · see citing works
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703 · see citing works
Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
Cohn, J. N., Archibald, D. G., Ziesche, S., Franciosa, J. A., Harston, W. E., Tristani, F. E., Dunkman, W. B., Jacobs, W., Francis, G. S., Flohr, K. H., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606123142404 · Cited by 2,400 · see citing works
(2000) · PubMed · Cited by 2,095 · see citing works
Role of diabetes in congestive heart failure: The Framingham study
Kannel, W. B., Hjortland, M., & Castelli, W. P. (1974) · The American Journal of Cardiology · doi:10.1016/0002-9149(74)90089-7 · Cited by 2,090 · see citing works
Survival after the onset of congestive heart failure in Framingham Heart Study subjects.
Ho, K. K. L., Anderson, K. M., Kannel, W. B., Grossman, W., & Levy, D. A. (1993) · Circulation · doi:10.1161/01.cir.88.1.107 · Cited by 1,865 · see citing works
Stearne, M. R., Palmer, S. L., Hammersley, M. S., Franklin, S. L., Spivey, R. S., Lévy, J., Tidy, C. R., Bell, N. J., Steemson, J., Barrow, B., et al. (1998) · BMJ · doi:10.1136/bmj.317.7160.713 · Cited by 1,784 · see citing works
Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
Taylor, A. L., Ziesche, S., Yancy, C., Carson, P., D'Agostino, R., Ferdinand, K., Taylor, M., Adams, K., Sabolinski, M., Worcel, M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042934 · Cited by 1,773 · see citing works
Lindholm, L. H., Ibsen, H., Dahlöf, B., Devereux, R. B., Beevers, G., de Faire, U., Fyhrquist, F., Julius, S., Kjeldsen, S. E., Kristiansson, K., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08090-x · Cited by 1,560 · see citing works
Diabetic Cardiomyopathy Revisited
Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543 · see citing works
Stearne, M. R., Palmer, S. L., Hammersley, M. S., Franklin, S. L., Spivey, R. S., Lévy, J., Tidy, C. R., Bell, N. J., Steemson, J., Barrow, B. A., et al. (1998) · UCL Discovery (University College London) · Cited by 1,406 · see citing works
He, J., Ogden, L. G., Bazzano, L. A., Vupputuri, S., Loria, C., & Whelton, P. K. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.7.996 · Cited by 1,172 · cited 1× · see citing works
“19), respectively.(10,11) In Iceland, the age-adjusted odds ratio (OR) for development of HF was 2.”
BackgroundPredictors of mortality and morbidity in patients with chronic heart failure
Pocock, S., Wang, D., Pfeffer, M. A., Yusuf, S., McMurray, J. J. V., Swedberg, K. B., Östergren, J., Michelson, E. L., Pieper, K. S., & Granger, C. B. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi555 · Cited by 972 · see citing works
Self-citationMehra, M. R., KOBASHIGAWA, J. A., Starling, R. C., Russell, S., Uber, P. A., Parameshwar, J. K., Mohaçsi, P., AUGUSTINE, S., Aaronson, K. D., & Barr, M. (2006) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2006.06.008 · Cited by 961 · see citing works
Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study
Gottdiener, J. S., Arnold, A. M., Aurigemma, G. P., Polak, J. F., Tracy, R. P., Kitzman, D. W., Gardin, J. M., Rutledge, J. E., & Boineau, R. C. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00582-9 · Cited by 907 · see citing works
Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure
Nesto, R. W., Bell, D. S. H., Bonow, R. O., Fonseca, V. A., Grundy, S. M., Horton, E. S., Winter, M. L., Porte, D., Semenkovich, C. F., Smith, S. E., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103683.99399.7e · Cited by 831 · see citing works
The Incidence of Congestive Heart Failure in Type 2 Diabetes
Nichols, G. A., Gullion, C. M., Koro, C. E., Ephross, S. A., & Brown, J. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.1879 · Cited by 812 · see citing works
Bakris, G. L., Fonseca, V., Katholi, R. E., McGill, J. B., Messerli, F. H., Phillips, R. A., Raskin, P., Wright, J. T., Oakes, R., Lukas, M. A., et al. (2004) · JAMA · doi:10.1001/jama.292.18.2227 · Cited by 792 · see citing works
Rosiglitazone Evaluated for Cardiovascular Outcomes — An Interim Analysis
Home, P. D., Pocock, S. J., Beck-Nielsen, H., Gomis, R., Hanefeld, M., Jones, N. P., Komajda, M., & McMurray, J. J. V. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073394 · Cited by 761 · see citing works
Self-citationLago, R. M., Singh, P. P., & Nesto, R. W. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61514-1 · Cited by 710 · see citing works
Glycemic Control and Heart Failure Among Adult Patients With Diabetes
Iribarren, C., Karter, A. J., Go, A. S., Ferrara, A. M., Liu, J. Y., Sidney, S. S., & Selby, J. V. (2001) · Circulation · doi:10.1161/01.cir.103.22.2668 · Cited by 703 · see citing works
Davies, M., Hobbs, F., Davis, R., Kenkre, J., Roalfe, A., Hare, R., Wosornu, D., & Lancashire, R. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05620-3 · Cited by 657 · see citing works
Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population
McDonagh, T. A., Morrison, C., Lawrence, A., Ford, I., Tunstall-Pedoe, H., McMurray, J. J. V., & Dargie, H. J. (1997) · The Lancet · doi:10.1016/s0140-6736(97)03033-x · Cited by 631 · see citing works
Self-citationHeart failure prevalence, incidence, and mortality in the elderly with diabetes
Bertoni, A. G., Hundley, W. G., Massing, M. W., Bonds, D. E., Burke, G. L., & Goff, D. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.699 · Cited by 596 · see citing works
New insights into sympathetic regulation of glucose and fat metabolism
Nonogaki, K. (2000) · Diabetologia · doi:10.1007/s001250051341 · Cited by 576 · see citing works
Insulin Resistance and Risk of Congestive Heart Failure
Ingelsson, E., Sundström, J., Ärnlöv, J., Zethelius, B., & Lind, L. (2005) · JAMA · doi:10.1001/jama.294.3.334 · Cited by 569 · see citing works
Evidence of Improving Prognosis in Heart Failure
Macintyre, K., Capewell, S., Stewart, S., Chalmers, J. W. T., Boyd, J., Finlayson, A. R., Redpath, A., Pell, J. P., & McMurray, J. J. V. (2000) · Circulation · doi:10.1161/01.cir.102.10.1126 · Cited by 553 · see citing works
Self-citationKnopp, R. H., d’Emden, M., Smilde, J. G., Pocock, S. J., & on behalf of the ASPEN Study Group (2006) · Diabetes Care · doi:10.2337/dc05-2415 · Cited by 550 · see citing works
Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure.
Swan, J. W., Anker, S., Walton, C., Godsland, I., Clark, A., Leyva, F., Stevenson, J., & Coats, A. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00185-x · Cited by 546 · see citing works
Shepherd, J., Barter, P., Carmena, R., Deedwania, P., Fruchart, J.-C., Haffner, S., Hsia, J., Breazna, A., LaRosa, J., Grundy, S., et al. (2006) · Diabetes Care · doi:10.2337/dc05-2465 · Cited by 525 · see citing works
Shindler, D. M., Kostis, J. B., Yusuf, S., Quinones, M. A., Pitt, B., Stewart, D., Pinkett, T., Ghali, J. K., Wilson, A. C., & The SOLVD Investigators (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89163-1 · Cited by 516 · see citing works
Shekelle, P. G., Rich, M. W., Morton, S. C., Atkinson, C. S. W., Tu, W., Maglione, M., Rhodes, S., Barrett, M., Fonarow, G. C., Greenberg, B., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00262-6 · Cited by 492 · see citing works
The prognosis of heart failure in the general population: the Rotterdam Study
Mosterd, A. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2533 · Cited by 470 · see citing works
Masoudi, F. A., Inzucchi, S. E., Wang, Y., Havranek, E. P., Foody, J. M., & Krumholz, H. M. (2005) · Circulation · doi:10.1161/01.cir.0000154542.13412.b1 · Cited by 458 · see citing works
Improved clinical outcomes associated with metformin in patients with diabetes and heart failure
Eurich, D. T., Majumdar, S. R., McAlister, F. A., Tsuyuki, R. T., & Johnson, J. A. (2005) · Diabetes Care · doi:10.2337/diacare.28.10.2345 · Cited by 419 · see citing works
Lactic Acidosis in Patients with Diabetes Treated with Metformin
Misbin, R. I., Green, L., Stadel, B. V., Gueriguian, J. L., Gubbi, A., & Fleming, G. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801223380415 · Cited by 403 · see citing works
Young, J. B., Dunlap, M. E., Pfeffer, M. A., Probstfield, J. L., Solal, A. C., Dietz, R., Granger, C. B., Hradec, J., Kuch, J., McKelvie, R. S., et al. (2004) · Circulation · doi:10.1161/01.cir.0000146819.43235.a9 · Cited by 397 · see citing works
Self-citationReduction in Cardiovascular Events With Atorvastatin in 2,532 Patients With Type 2 Diabetes
Sever, P. S., Poulter, N. R., Dahlöf, B., Wedel, H., Collins, R., Beevers, G., Caulfield, M., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1151 · Cited by 390 · see citing works
Thrainsdottir, I. S., Aspelund, T., Thorgeirsson, G., Gudnason, V., Hardarson, T., Malmberg, K., Sigurdsson, G., & Rydén, L. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.612 · Cited by 374 · see citing works
Scherrer, U., & Sartori, C. (1997) · Circulation · doi:10.1161/01.cir.96.11.4104 · Cited by 371 · see citing works
Raymond, I. E., Groenning, B. A., Hildebrandt, P. R., Nilsson, J. C., Baumann, M., Trawinski, J., & Pedersen, F. (2003) · Heart · doi:10.1136/heart.89.7.745 · Cited by 351 · see citing works
Insulin-Resistant Cardiomyopathy
Witteles, R. M., & Fowler, M. B. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.021 · Cited by 349 · see citing works
Raskin, P., Rendell, M., Riddle, M. C., Dole, J., Freed, M. I., & Rosenstock, J. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1226 · Cited by 345 · see citing works
Giugliano, D., Acampora, R., Marfella, R., De Rosa, N., Ziccardi, P., Ragone, R., De Angelis, L., & D'Onofrio, F. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-12-199706150-00004 · Cited by 302 · see citing works
Diabetes in heart failure: prevalence and impact on outcome in the population
From, A. M., Leibson, C. L., Bursi, F., Redfield, M. M., Weston, S. A., Jacobsen, S. J., Rodeheffer, R. J., & Roger, V. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.05.024 · Cited by 295 · cited 1× · see citing works
“population study found the increased mortality risk of DM was confined to patients with HF of non-ischaemic aetiology.(27) This”
BackgroundDoehner, W., Rauchhaus, M., Ponikowski, P., Godsland, I. F., von Haehling, S., Okonko, D. O., Leyva, F., Proudler, A. J., Coats, A. J. S., & Anker, S. D. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.093 · Cited by 294 · see citing works
Dries, D. L., Sweitzer, N. K., Drazner, M. H., Stevenson, L. W., & Gersh, B. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01408-5 · Cited by 286 · see citing works
Mechanisms of the free fatty acid-induced increase in hepatic glucose production
Lam, T. K. T., Carpentier, A. C., Lewis, G. F., van de Werve, G., Fantus, I. G., & Giacca, A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00033.2003 · Cited by 283 · see citing works
Suskin, N. (2000) · European Heart Journal · doi:10.1053/euhj.1999.2043 · Cited by 271 · see citing works
Gustafsson, I., Brendorp, B., Seibæk, M., Burchardt, H., Hildebrandt, P., Køber, L., & Torp-Pedersen, C. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.024 · Cited by 258 · see citing works
Sutton, M. S. J., Rendell, M., Dandona, P., Dole, J., Murphy, K., Patwardhan, R., Patel, J., & Freed, M. I. (2002) · Diabetes Care · doi:10.2337/diacare.25.11.2058 · Cited by 254 · see citing works
Race, Quality of Care, and Outcomes of Elderly Patients Hospitalized With Heart Failure
Rathore, S. S. (2003) · JAMA · doi:10.1001/jama.289.19.2517 · Cited by 252 · see citing works
Vermes, E., Ducharme, A., Bourassa, M. G., Lessard, M., White, M., & Tardif, J.-C. (2003) · Circulation · doi:10.1161/01.cir.0000054611.89228.92 · Cited by 248 · see citing works
Heart Failure Survival Among Older Adults in the United States
Croft, J. B., Giles, W. H., Pollard, R. A., Keenan, N. L., Casper, M. L., & Anda, R. F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.5.505 · Cited by 239 · see citing works
Retinopathy and Risk of Congestive Heart Failure
Wong, T. Y. (2005) · JAMA · doi:10.1001/jama.293.1.63 · Cited by 226 · see citing works
Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme
Herings, R. M. C., de Boer, A., Leufkens, H. G. M., Porsius, A., & Stricker, B. H. C. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91988-0 · Cited by 217 · see citing works
The effect of diabetes on outcomes of patients with advanced heart failure in the BEST trial
Domanski, M., Krause-Steinrauf, H., Deedwania, P., Follmann, D., Ghali, J. K., Gilbert, E., Haffner, S., Katz, R., Lindenfeld, J., Lowes, B. D., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00856-8 · Cited by 215 · see citing works
Yusuf, S., Östergren, J., Gerstein, H. C., Pfeffer, M. A., Swedberg, K. B., Granger, C. B., Olofsson, B., Probstfield, J. L., & McMurray, J. J. V. (2005) · Circulation · doi:10.1161/circulationaha.104.528166 · Cited by 213 · see citing works
Self-citationDargie, H. J., Hildebrandt, P. R., Riegger, G. A. J., McMurray, J. J. V., McMorn, S. O., ROBERTS, J. N., Zambanini, A., & Wilding, J. P. H. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.077 · Cited by 205 · see citing works
Self-citationSmooke, S., Horwich, T. B., & Fonarow, G. C. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.07.005 · Cited by 196 · see citing works
Haas, S. J., Vos, T., Gilbert, R. E., & Krum, H. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00403-4 · Cited by 194 · see citing works
Rosenstock, J., EINHORN, D. F., Hershon, K. S., Glazer, N. B., & Yu, S. S. (2002) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2002.tb11251.x · Cited by 193 · see citing works
Amato, L., Paolisso, G., Cacciatore, F., Ferrara, N., Ferrara, P., Canonico, S., Varricchio, M., & Rengo, F. (1997) · PubMed · Cited by 193 · see citing works
How Free Fatty Acids Inhibit Glucose Utilization in Human Skeletal Muscle
Roden, M. (2004) · Physiology · doi:10.1152/nips.01459.2003 · Cited by 193 · see citing works
Impact of diabetes mellitus on long-term survival in patients with congestive heart failure
de Groote, P. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.01.010 · Cited by 192 · see citing works
Erland, E., Philippe, L., Patricia, V., & Hermann, W. (2001) · European Journal of Heart Failure · doi:10.1016/s1388-9842(01)00174-x · Cited by 190 · see citing works
Morgan, S., Smith, H. E., Simpson, I. A., Liddiard, G. S., Raphael, H., Pickering, R. M., & Mant, D. (1999) · BMJ · doi:10.1136/bmj.318.7180.368 · Cited by 178 · see citing works
Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure
Paolisso, G., Riu, S. D., Marrazzo, G., Verza, M., Varricchio, M., & D’Onofrio, F. (1991) · Metabolism · doi:10.1016/0026-0495(91)90075-8 · Cited by 174 · see citing works
RYDEN, L. (2000) · European Heart Journal · doi:10.1053/euhj.2000.2311 · Cited by 174 · see citing works
Torp-Pedersen, C., Metra, M., Charlesworth, A., Spark, P., Lukas, M. A., Poole-Wilson, P. A., Swedberg, K., Cleland, J. G. F., Di Lenarda, A., Remme, W. J., et al. (2007) · Heart · doi:10.1136/hrt.2006.092379 · Cited by 171 · see citing works
Vaur, L., Gueret, P., Lievre, M., Chabaud, S., Passa, P., & For the DIABHYCAR Study Group (2003) · Diabetes Care · doi:10.2337/diacare.26.3.855 · Cited by 163 · see citing works
Tang, W. H. W., Francis, G. S., Hoogwerf, B. J., & Young, J. B. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00159-1 · Cited by 150 · see citing works
Eshaghian, S., Horwich, T. B., & Fonarow, G. C. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.10.008 · Cited by 145 · see citing works
Incidence of heart failure in 2,737 older persons with and without diabetes mellitus
Aronow, W. S., & Ahn, C. (1999) · Chest · doi:10.1378/chest.115.3.867 · Cited by 144 · see citing works
Deedwania, P. C., Giles, T. D., Klibaner, M., Ghali, J. K., Herlitz, J., Hildebrandt, P., Kjekshus, J., Spinar, J., Vitovec, J., Stanbrook, H., et al. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.05.056 · Cited by 143 · see citing works
Brophy, J. M., Dagenais, G. R., McSherry, F., Williford, W., & Yusuf, S. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.09.035 · Cited by 136 · see citing works
Epshteyn, V. A., Morrison, K. C., Krishnaswamy, P., Kazanegra, R., Clopton, P., Mudaliar, S. R. D., Edelman, S. V., Henry, R., & Maisel, A. S. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2081 · Cited by 136 · see citing works
Daly, C., Fox, K. M., Remme, W. J., Bertrand, M. E., Ferrari, R., & Simoons, M. L. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi225 · Cited by 131 · see citing works
Phenformin-Associated Lactic Acidosis: Pathogenesis and Treatment
Misbin, R. I. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-5-591 · Cited by 118 · see citing works
Shorr, R. I., Ray, W. A., Daugherty, J. R., & Griffin, M. R. (1997) · PubMed · Cited by 114 · see citing works
Taylor, A. L., Ziesche, S., Yancy, C. W., Carson, P., Ferdinand, K., Taylor, M., Adams, K., Olukotun, A. Y., Ofili, E., Tam, S. W., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.644013 · Cited by 114 · see citing works
Kirklin, J. K., Naftel, D. C., Bourge, R. C., McGiffin, D. C., Hill, J. A., Rodeheffer, R. J., Jaski, B. E., Hauptman, P. J., Weston, M., & White‐Williams, C. (2003) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2003.168 · Cited by 113 · see citing works
Morris, A. D., Boyle, D. I., McMahon, A. D., Pearce, H., Evans, J. M. M., Newton, R. W., Jung, R. T., MacDonald, T. M., & The Darts/Memo Collaboration (1997) · Diabetes Care · doi:10.2337/diacare.20.9.1363 · Cited by 109 · see citing works
Impact of race on health care utilization and outcomes in veterans with congestive heart failure
Deswal, A. M., Petersen, N. J., Souchek, J., Ashton, C. M., & Wray, N. P. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.033 · Cited by 109 · see citing works
Carr, A. A., Kowey, P. R., Devereux, R. B., Brenner, B. M., Dahlöf, B., Ibsen, H., Lindholm, L. H., Lyle, P. A., Snapinn, S. M., Zhang, Z., et al. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.07.061 · Cited by 107 · see citing works
Whang, W., & Bigger, J. T. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00823-8 · Cited by 106 · see citing works
Functional class in patients with heart failure is associated with the development of diabetes
Tenenbaum, A., Motro, M., Fisman, E. Z., Leor, J., Freimark, D., Boyko, V., Mandelzweig, L., Adler, Y., Sherer, Y., & Behar, S. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01530-9 · Cited by 99 · see citing works
The Association of Heart Failure With Insulin Resistance and the Development of Type 2 Diabetes
Kostis, J. B., & SANDERS, M. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.038 · Cited by 92 · see citing works
Pioglitazone initiation and subsequent hospitalization for congestive heart failure
Karter, A., Ahmed, A., Liu, J., Moffet, H. M., & Parker, M. M. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01704.x · Cited by 90 · see citing works
Left ventricular systolic dysfunction in 75-year-old men and women. A population-based study
Hedberg, P. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2284 · Cited by 89 · see citing works
β1- andβ2-Adrenoceptor-Mediated Thermogenesis and Lipid Utilization in Obese and Lean Men1
Schiffelers, S. L. H., Saris, W. H. M., Boomsma, F., & van Baak, M. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7506 · Cited by 86 · see citing works
Shorr, R. I. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03550010054039 · Cited by 83 · cited 13× · see citing works
“Insulin resistance, in the absence of DM, is an independent prognostic indicator in HF.45 Similarly, an admission blood glucose of .10 mmol/L is a predictor of mortality, independent of DM, in patients with a first hospitalization for HF.46 Why do patients with heart failure develop insulin resistance?”
BackgroundInfluentialTaylor, J. (2007) · PubMed · Cited by 82 · see citing works
Erdmann, E., & Wilcox, R. G. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm529 · Cited by 79 · see citing works
Michel Komajda, N., Lutiger, B., Madeira, H. C., Thygesen, K. A., Bobbio, M., Hildebrandt, P. R., Jaarsma, W., Riegger, G. A. J., Rydén, L., Scherhag, A. W., et al. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2003.12.019 · Cited by 74 · see citing works
Das, S. R., Drazner, M. H., Yancy, C. W., Stevenson, L. W., Gersh, B. J., & Dries, D. L. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.04.019 · Cited by 68 · see citing works
Popp, D. A., Tse, T. F., Shah, S. D., Clutter, W. E., & Cryer, P. E. (1984) · Diabetes Care · doi:10.2337/diacare.7.3.243 · Cited by 62 · see citing works
Guazzi, M., Brambilla, R., Pontone, G., Agostoni, P., & Guazzi, M. D. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02199-3 · Cited by 61 · see citing works
Bobbio, M., Ferrua, S., Opasich, C., Porcu, M., Lucci, D., Scherillo, M., Tavazzi, L., & Maggioni, A. P. (2003) · Journal of Cardiac Failure · doi:10.1054/jcaf.2003.31 · Cited by 56 · see citing works
Betablocker treatment in diabetes mellitus
Sawicki, P. T., & Siebenhofer, A. (2001) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2001.00829.x · Cited by 53 · see citing works
Kerr, D. E., Macdonald, I. A., Heller, S. R., & Rb, T. (1990) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1990.tb03689.x · Cited by 52 · see citing works
Diabetes lowers six-minute walk test performance in heart failure
Ingle, L., Reddy, P., Clark, A. L., & Cleland, J. G. F. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.02.005 · Cited by 51 · see citing works
Ghali, J. K., Boehmer, J., Feldman, A. M., Saxon, L. A., Demarco, T., Carson, P., Yong, P., Galle, E. G., Leigh, J., Ecklund, F. L., et al. (2007) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2007.06.723 · Cited by 50 · see citing works
Glucose and haemoglobin in the assessment of prognosis after first hospitalisation for heart failure
Newton, J. D., & Squire, I. B. (2006) · Heart · doi:10.1136/hrt.2005.080895 · Cited by 47 · see citing works
Hoppe, U. C., Freemantle, N., Cleland, J. G. F., Marijianowski, M., & Erdmann, E. (2007) · Diabetes Care · doi:10.2337/dc06-2035 · Cited by 43 · see citing works
Wittenberg, S. M., Cook, J. R., Hall, W. J., McNitt, S. A., Zaręba, W., & Moss, A. J. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.090 · Cited by 38 · see citing works
Aguilar, D. A., Bozkurt, B., Pritchett, A. M., Petersen, N. J., & Deswal, A. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.096 · Cited by 35 · see citing works
Self-citationSpironolactone in Patients with Heart Failure
Larkin, R. J., Atlas, S., & Donohue, T. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200001133420213 · Cited by 35 · see citing works
Decreased Survival in Diabetic Patients with Heart Failure Due to Systolic Dysfunction
Kamalesh, M., Subramanian, U., Sawada, S. G., Eckert, G. J., Temkit, M., & Tierney, W. M. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2005.10.005 · Cited by 34 · see citing works
Prevalence and characteristics of diabetic patients in a chronic heart failure population
Kistorp, C., Galatius, S., Gustafsson, F., Faber, J., Corell, P., & Hildebrandt, P. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.10.024 · Cited by 33 · see citing works
Diabetes Lowers Aerobic Capacity in Heart Failure
Tibb, A. S., Ennezat, P. V., Chen, J. A., Haider, A., Gundewar, S., Cotarlan, V., Aggarwal, V. S., Talreja, A., & Jemtel, T. H. L. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.001 · Cited by 29 · see citing works
Bhatia, V., Wilding, G. E., Dhindsa, G., Bhatia, R., Garg, R., Bonner, A. J., & Dhindsa, S. (2004) · Endocrine Practice · doi:10.4158/ep.10.6.467 · Cited by 29 · see citing works
Albuminuria as a predictor of heart failure hospitalizations in patients with type 2 diabetes
Hockensmith, M. L., Estacio, R. O., Mehler, P. S., Havranek, E. P., Ecder, T., Lundgren, R. A., & Schrier, R. W. (2004) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2003.09.003 · Cited by 27 · see citing works
Does Carvedilol Impair Insulin Sensitivity in Heart Failure Patients Without Diabetes?
Ferrua, S., Bobbio, M., Catalano, E., Grassi, G., Massobrio, N., Pinach, S., Rossi, C., Veglio, M., & Trevi, G. P. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2005.06.431 · Cited by 21 · see citing works
CHART: Congestive cardiac failure in hospitals, an Australian review of treatment
Wlodarczyk, J. H., KEOGH, A. M., Smith, K., & McCosker, C. (2003) · Heart Lung and Circulation · doi:10.1046/j.1444-2892.2003.00197.x · Cited by 19 · see citing works
Heart Failure and Diabetes: Collateral Benefit of Chronic Disease Management
Ware, M. G., Flavell, C. M., Lewis, E. F., Nohria, A., Warner‐Stevenson, L., & Givertz, M. M. (2006) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2005.05354.x · Cited by 10 · see citing works
Diabetes affects long-term survival after heart transplantation
Czerny, M., Sahin, V., Zuckermann, A. O., et al. (2001) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(00)00555-6 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Seferović, P. M., Petrie, M. C., Filippatos, G. S., Anker, S. D., Rosano, G., Bauersachs, J., Paulus, W. J., Komajda, M., Cosentino, F., de Boer, R. A., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1170 · Cited by 708 · see citing works
Self-citationMetformin: An Old But Still the Best Treatment for Type 2 Diabetes
Rojas, L. B. A., & Gomes, M. B. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-6 · Cited by 567 · see citing works
Cubbon, R. M., Adams, B., Rajwani, A., Mercer, B. N., Patel, P. A., Gherardi, G., Gale, C. P., Batin, P. D., Ajjan, R., Kearney, L., et al. (2013) · Diabetes and Vascular Disease Research · doi:10.1177/1479164112471064 · Cited by 167 · see citing works
McMurray, J. J. V., Ponikowski, P., Bolli, G. B., Lukashevich, V., Kozlovski, P., Kothny, W., Lewsey, J. D., & Krum, H. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2017.08.004 · Cited by 165 · see citing works
Self-citationMean HbA1c and mortality in diabetic individuals with heart failure: a population cohort study
Elder, D. H. J., Singh, J. S. S., Levin, D., Donnelly, L. A., Choy, A.-M., George, J., Struthers, A. D., Doney, A. S. F., & Lang, C. C. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.455 · Cited by 109 · see citing works
Metformin Therapy and Outcomes in Patients With Advanced Systolic Heart Failure and Diabetes
Shah, D. D., Fonarow, G. C., & Horwich, T. B. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2009.10.022 · Cited by 100 · see citing works
CD38 promotes angiotensin II‐induced cardiac hypertrophy
Guan, X., Hong, X., Zhao, N., Liu, X., Xiao, Y., Chen, T., Deng, L., Wang, X., Wang, J., Ji, G., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13076 · Cited by 90 · see citing works
Preiss, D., van Veldhuisen, D. J., Sattar, N., Krum, H., Swedberg, K., Shi, H., Vincent, J., Pocock, S. J., Pitt, B., Zannad, F., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs067 · Cited by 79 · see citing works
Self-citationKomajda, M., Tavazzi, L., Francq, B. G., Böhm, M., Borer, J. S., Ford, I., & Swedberg, K. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.347 · Cited by 76 · see citing works
Preiss, D., Zetterstrand, S., McMurray, J. J. V., Östergren, J., Michelson, E. L., Granger, C. B., Yusuf, S., Swedberg, K., Pfeffer, M. A., Gerstein, H. C., et al. (2009) · Diabetes Care · doi:10.2337/dc08-1709 · Cited by 76 · see citing works
Self-citationMacDonald, M. R., Jhund, P. S., Petrie, M. C., Lewsey, J. D., Hawkins, N. M., Bhagra, S., Munoz, N., Varyani, F., Redpath, A., Chalmers, J., et al. (2008) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.794008 · Cited by 64 · see citing works
Parissis, J. T., Rafouli-Stergiou, P., Mebazaa, A., Ikonomidis, I., Bistola, V., Nikolaou, M., Meas, T., Delgado, J., Vilas-Boas, F., Paraskevaidis, I., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.11.098 · Cited by 58 · see citing works
Lambadiari, V., Thymis, J., Kouretas, D., Skaperda, Z., Tekos, F., Kousathana, F., Kountouri, A., Balampanis, K., Parissis, J., Andreadou, I., et al. (2021) · Antioxidants · doi:10.3390/antiox10091379 · Cited by 42 · see citing works
Abdul-Rahim, A. H., MacIsaac, R. L., Jhund, P. S., Petrie, M. C., Lees, K. R., & McMurray, J. J. V. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.02.074 · Cited by 29 · see citing works
Self-citationMacDonald, M. R., She, L., Doenst, T., Binkley, P. F., Rouleau, J. L., Tan, R.-S., Lee, K. L., Miller, A. B., Sopko, G., Szalewska, D., et al. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.288 · Cited by 24 · see citing works
Chen, P., Li, S., Lei, X., Liu, Z., Luo, Y., Wu, D., & Xu, D. (2015) · The American Journal of the Medical Sciences · doi:10.1097/maj.0000000000000524 · Cited by 18 · see citing works
- Authors
- MacDonald, M. R., Petrie, M. C., Hawkins, N. M., Petrie, J. R., Fisher, M., McKelvie, R., Aguilar, D., Krum, H., & McMurray, J. J. V.
- Affiliations
- Glasgow Royal Infirmary (GB)
- Aintree University Hospital (GB)
- University of Dundee (GB)
- McMaster University (CA)
- Baylor College of Medicine (US)
- The Alfred Hospital (AU)
- Western Infirmary (GB)
- Corresponding author
- MacDonald, Michael R.
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-04-18
- Volume
- 29
- Issue
- 10
- Pages
- 1224-1240
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2016818962
- Semantic Scholar
- e50d19e468359de0bcfe47f8d112acd285cad128
- Cited by
- 227
- References
- 135
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 8 · 2021: 15 · 2020: 17 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 18 · 2013: 12 · 2012: 11
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- diabetes mellitus, chronic heart failure, left ventricular systolic dysfunction, comorbidities, pathophysiological pathways, treatment options, morbidity and mortality risk
- MeSH terms
- Blood Glucose, Cardiotonic Agents, Chronic Disease, Diabetic Angiopathies, Humans, Hypoglycemic Agents, Insulin Resistance, Prognosis, Risk Factors, Heart Failure, Systolic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
