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Cited by 183Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsAcute Ischemic Stroke Management

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Maintenance of sinus rhythm with an ablation strategy in patients with atrial fibrillation is associated with a lower risk of stroke and death

Hunter, Ross J, McCready, James, Diab, Ihab, Page, Stephen P, Finlay, Malcolm, Richmond, Laura, French, Antony, Earley, Mark J, Sporton, Simon, Jones, Michael, Joseph, Jubin P, Bashir, Yaver, Betts, Tim R, Thomas, Glyn, Staniforth, Andrew, Lee, Geoffrey, Kistler, Peter, Rajappan, Kim, Chow, Anthony, Schilling, Richard J·2012·Heart
DOI 10.1136/heartjnl-2011-300720
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Abstract

OBJECTIVE: To investigate whether catheter ablation of atrial fibrillation (AF) reduces stroke rate or mortality. METHODS: An international multicentre registry was compiled from seven centres in the U.K. and Australia for consecutive patients undergoing catheter ablation of AF. Long-term outcomes were compared with (1) a cohort with AF treated medically in the Euro Heart Survey, and (2) a hypothetical cohort without AF, age and gender matched to the general population. Analysis of stroke and death was carried out after the first procedure (including peri-procedural events) regardless of success, on an intention-to-treat basis. RESULTS: 1273 patients, aged 58±11 years, 56% paroxysmal AF, CHADS(2) score 0.7±0.9, underwent 1.8±0.9 procedures. Major complications occurred in 5.4% of procedures, including stroke/TIA in 0.7%. Freedom from AF following the last procedure was 85% (76% off antiarrhythmic drugs) for paroxysmal AF, and 72% (60% off antiarrhythmic drugs) for persistent AF. During 3.1 (1.0-9.6) years from the first procedure, freedom from AF predicted stroke-free survival on multivariate analysis (HR=0.30, CI 0.16 to 0.55, p<0.001). Rates of stroke and death were significantly lower in this cohort (both 0.5% per patient-year) compared with those treated medically in the Euro Heart Survey (2.8% and 5.3%, respectively; p<0.0001). Rates of stroke and death were no different from those of the general population (0.4% and 1.0%, respectively). CONCLUSION: Restoration of sinus rhythm by catheter ablation of AF is associated with lower rates of stroke and death compared with patients treated medically.

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Crossref · 10.1136/heartjnl-2011-300720

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Research works printed but not linked: 1

  1. Bunch, 2006, Mortality benefit and quality of life outcomes in patients undergoing curative ablation for atrial fibrillation: comparison with a disease-matched community population, Circulation, 114, 602

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Metadata

Authors
Hunter, R. J., McCready, J., Diab, I., Page, S. P., Finlay, M., Richmond, L., French, A., Earley, M. J., Sporton, S., Jones, M., Joseph, J. P., Bashir, Y., Betts, T. R., Thomas, G., Staniforth, A., Lee, G., Kistler, P., Rajappan, K., Chow, A., & Schilling, R. J.
Affiliations
  • St Bartholomew's Hospital (GB)
  • University College Hospital at Westmoreland Street (GB)
  • Barts Health NHS Trust (GB)
  • John Radcliffe Hospital (GB)
  • Nottingham University Hospitals NHS Trust (GB)
  • Baker Heart and Diabetes Institute (AU)
Corresponding author
Schilling, Richard J
ORCID
Venue
Heart
Publisher
BMJ
Published
2011-09-19
Volume
98
Issue
1
Pages
48-53
ISSN
  • 1355-6037 (ISSN-L)
  • 1468-201X
DOI
10.1136/heartjnl-2011-300720
OpenAlex
W2053064155
Cited by
183
References
28
Citations by year
2026: 5 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 11 · 2017: 17 · 2016: 12 · 2015: 14 · 2014: 37 · 2013: 24 · 2012: 11
FWCI
16.00
Type
journal article
Language
en
Open access
closed
Locations
  • Heart (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
British Heart Foundation (PG/08/130)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
atrial fibrillation, catheter ablation, sinus rhythm restoration, stroke prevention, mortality, antiarrhythmic drugs, paroxysmal atrial fibrillation, persistent atrial fibrillation, CHADS2 score, long-term outcomes
MeSH terms
Administration, Oral, Aged, Anticoagulants, Atrial Fibrillation, Female, Hemorrhage, Humans, Male, Middle Aged, Risk Factors, Case-Control Studies, Treatment Outcome, Catheter Ablation, Stroke, Kaplan-Meier Estimate

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