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Cited by 357

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease

Open access
Sado, Daniel M, Flett, Andrew S, Banypersad, Sanjay M, White, Steven K, Maestrini, Viviana, Quarta, Giovanni, Lachmann, Robin H, Murphy, Elaine, Mehta, Atul, Hughes, Derralynn A, McKenna, William J, Taylor, Andrew M, Hausenloy, Derek J, Hawkins, Philip N, Elliott, Perry M, Moon, James C·2012·Heart
DOI 10.1136/heartjnl-2012-302346
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Abstract

Objective: To measure and assess the significance of myocardial extracellular volume (ECV), determined non-invasively by equilibrium contrast cardiovascular magnetic resonance, as a clinical biomarker in health and a number of cardiac diseases of varying pathophysiology. Design: Prospective study. Setting: Tertiary referral cardiology centre in London, UK. Patients: 192 patients were mainly recruited from specialist clinics. We studied patients with Anderson–Fabry disease (AFD, n=17), dilated cardiomyopathy (DCM, n=31), hypertrophic cardiomyopathy (HCM, n=31), severe aortic stenosis (AS, n=66), cardiac AL amyloidosis (n=27) and myocardial infarction (MI, n=20). The results were compared with those for 81 normal subjects. Results: In normal subjects, ECV (mean (95% CI), measured in the septum) was slightly higher in women than men (0.273 (0.264 to 0.282 vs 0.233 (0.225 to 0.244), p<0.001), with no change with age. In disease, the ECV of AFD was the same as in normal subjects but higher in all other diseases (p<0.001). Mean ECV was the same in DCM, HCM and AS (0.280, 0.291, 0.276 respectively), but higher in cardiac AL amyloidosis and higher again in MI (0.466 and 0.585 respectively, each p<0.001). Where ECV was elevated, correlations were found with indexed left ventricular mass, end systolic volume, ejection fraction and left atrial area in apparent disease-specific patterns. Conclusions: Myocardial ECV, assessed non-invasively in the septum with equilibrium contrast cardiovascular magnetic resonance, shows gender differences in normal individuals and disease-specific variability. Therefore, ECV shows early potential to be a useful biomarker in health and disease.

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Metadata

Authors
Sado, D. M., Flett, A. S., Banypersad, S. M., White, S. K., Maestrini, V., Quarta, G., Lachmann, R. H., Murphy, E., Mehta, A., Hughes, D. A., McKenna, W. J., Taylor, A. M., Hausenloy, D. J., Hawkins, P. N., Elliott, P. M., & Moon, J. C.
Venue
Heart
Publisher
BMJ
Published
2012-08-30
Volume
98
Issue
19
Pages
1436-1441
ISSN
  • 1355-6037 (ISSN-L)
  • 1468-201X
DOI
10.1136/heartjnl-2012-302346
OpenAlex
W2122244728
Cited by
357
References
31
FWCI
20.69
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease. https://app.cochat.ai/papers/10.1136/heartjnl-2012-302346
The paper
Sado, D. M., Flett, A. S., Banypersad, S. M., White, S. K., Maestrini, V., Quarta, G., Lachmann, R. H., Murphy, E., Mehta, A., Hughes, D. A., McKenna, W. J., Taylor, A. M., Hausenloy, D. J., Hawkins, P. N., Elliott, P. M., & Moon, J. C. (2012). Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease. Heart. https://doi.org/10.1136/heartjnl-2012-302346

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.