The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Equilibrium Contrast Cardiovascular Magnetic Resonance for the Measurement of Diffuse Myocardial Fibrosis: Preliminary Validation in Humans
Open accessAbstract
Background— Diffuse myocardial fibrosis is a final end point in most cardiac diseases. It is missed by the cardiovascular magnetic resonance (CMR) late gadolinium enhancement technique. Currently, quantifying diffuse myocardial fibrosis requires invasive biopsy, with inherent risk and sampling error. We have developed a robust and noninvasive technique, equilibrium contrast CMR (EQ–CMR) to quantify diffuse fibrosis and have validated it against the current gold standard of surgical myocardial biopsy. Methods and Results— The 3 principles of EQ–CMR are a bolus of extracellular gadolinium contrast followed by continuous infusion to achieve equilibrium; a blood sample to measure blood volume of distribution (1−hematocrit); and CMR to measure pre- and postequilibrium T1 (with heart rate correction). The myocardial volume of distribution is calculated, reflecting diffuse myocardial fibrosis. Clinical validation occurred in patients undergoing aortic valve replacement for aortic stenosis or myectomy in hypertrophic cardiomyopathy (n=18 and n=8, respectively). Surgical biopsies were analyzed for picrosirius red fibrosis quantification on histology. The mean histological fibrosis was 20.5±11% in aortic stenosis and 17.1±7.4% in hypertrophic cardiomyopathy. EQ–CMR correlated strongly with biopsy histological fibrosis: aortic stenosis, r 2 =0.86, Kendall Tau coefficient (T)=0.71, P <0.001; hypertrophic cardiomyopathy, r 2 =0.62, T=0.52, P =0.08; combined r 2 =0.80, T=0.67, P <0.001. Conclusions— We have developed and validated a new technique, EQ–CMR, to measure diffuse myocardial fibrosis as an add-on to a standard CMR scan, which allows for the noninvasive quantification of the diffuse fibrosis burden in myocardial diseases.
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Cites
Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis
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Cardiovascular Magnetic Resonance in Cardiac Amyloidosis
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Self-citationHachicha, Z., Dumesnil, J. G., Bogaty, P., & Pibarot, P. (2007) · Circulation · doi:10.1161/circulationaha.106.668681 · Cited by 959
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Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report?
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Self-citationImpact of Myocardial Fibrosis in Patients With Symptomatic Severe Aortic Stenosis
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Cited by
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001063 · Cited by 4,922
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862
Dweck, M. R., Boon, N. A., & Newby, D. E. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.093 · Cited by 692
Sado, D. M., Flett, A. S., Banypersad, S. M., White, S. K., Maestrini, V., Quarta, G., Lachmann, R. H., Murphy, E., Mehta, A., Hughes, D. A., et al. (2012) · Heart · doi:10.1136/heartjnl-2012-302346 · Cited by 357
Self-citationLiu, C.-Y., Liu, Y.-C., Wu, C., Armstrong, A., Volpe, G. J., van der Geest, R. J., Liu, Y., Hundley, W. G., Gomes, A. S., Liu, S., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.078 · Cited by 349
Metadata
- Authors
- Flett, A. S., Hayward, M. P., Ashworth, M. T., Hansen, M. S., Taylor, A. M., Elliott, P. M., McGregor, C., & Moon, J. C.
- Venue
- Circulation
- Published
- 2010-07-13
- Volume
- 122
- Issue
- 2
- Pages
- 138-144
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2039057919
- Cited by
- 915
- References
- 27
- FWCI
- 43.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Flett, A. S., Hayward, M. P., Ashworth, M. T., Hansen, M. S., Taylor, A. M., Elliott, P. M., McGregor, C., & Moon, J. C. (2010). Equilibrium Contrast Cardiovascular Magnetic Resonance for the Measurement of Diffuse Myocardial Fibrosis: Preliminary Validation in Humans. Circulation. https://doi.org/10.1161/circulationaha.109.930636
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