The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The role of uric acid in the pathogenesis of human cardiovascular disease
Abstract
Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have emerging roles in the pathogenesis of kidney disease, metabolic syndrome and diabetes. More studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease.
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Cites
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.23.2981 · Cited by 5,664
Yu, M.-A., Sánchez-Lozada, L. G., Johnson, R. J., & Kang, D.-H. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328337da1d · Cited by 626
Self-citationHyperuricemia and risk of stroke: A systematic review and meta‐analysis
Kim, S. Y., Guevara, J. P., Kim, K. M., Choi, H. K., Heitjan, D. F., & Albert, D. A. (2009) · Arthritis Care & Research · doi:10.1002/art.24612 · Cited by 484
Allopurinol Improves Myocardial Efficiency in Patients With Idiopathic Dilated Cardiomyopathy
Cappola, T. P., Kass, D. A., Nelson, G. S., Berger, R. D., Rosas, G. O., Kobeissi, Z. A., Marbán, E., & Hare, J. M. (2001) · Circulation · doi:10.1161/hc4501.098928 · Cited by 436
Impact of Oxypurinol in Patients With Symptomatic Heart Failure
Hare, J. M., Mangal, B., Brown, J., Fisher, C., Freudenberger, R., Colucci, W. S., Mann, D. L., Liu, P., Givertz, M. M., & Schwarz, R. P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.068 · Cited by 392
Xanthine Oxidase Inhibition Reverses Endothelial Dysfunction in Heavy Smokers
Guthikonda, S., Sinkey, C., Barenz, T., & Haynes, W. G. (2003) · Circulation · doi:10.1161/01.cir.0000046448.26751.58 · Cited by 225
Cited by
Tang, W. H. W., Wang, Z., Fan, Y., Levison, B., Hazen, J. E., Donahue, L. M., Wu, Y., & Hazen, S. L. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.617 · Cited by 681
Metadata
- Authors
- Kanbay, M., Segal, M., Afsar, B., Kang, D.-H., Rodriguez-Iturbe, B., & Johnson, R. J.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2013-01-23
- Volume
- 99
- Issue
- 11
- Pages
- 759-766
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W2141653683
- Cited by
- 454
- References
- 6
- FWCI
- 26.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
