The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries
Open accessAbstract
Objective: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies. Methods: Cross-sectional data from 24 population-based studies from 15 countries, with a total sample size of 237 979 subjects. CVRFs included Body Mass Index (BMI) and waist circumference; systolic (SBP) and diastolic (DBP) blood pressure; total, high (HDL) and low (LDL) density lipoprotein cholesterol; triglycerides and glucose levels. Within each study, all data were adjusted for age, gender and current smoking. For blood pressure, lipids and glucose levels, further adjustments on BMI and drug treatment were performed. Results: In the Northern and Southern Hemispheres, CVRFs levels tended to be higher in winter and lower in summer months. These patterns were observed for most studies. In the Northern Hemisphere, the estimated seasonal variations were 0.26 kg/m 2 for BMI, 0.6 cm for waist circumference, 2.9 mm Hg for SBP, 1.4 mm Hg for DBP, 0.02 mmol/L for triglycerides, 0.10 mmol/L for total cholesterol, 0.01 mmol/L for HDL cholesterol, 0.11 mmol/L for LDL cholesterol, and 0.07 mmol/L for glycaemia. Similar results were obtained when the analysis was restricted to studies collecting fasting blood samples. Similar seasonal variations were found for most CVRFs in the Southern Hemisphere, with the exception of waist circumference, HDL, and LDL cholesterol. Conclusions: CVRFs show a seasonal pattern characterised by higher levels in winter, and lower levels in summer. This pattern could contribute to the seasonality of CV mortality.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This is to some extent due to analytical variation, but is also due to environmental factors such as diet and physical activity, and a seasonal variation, with higher levels of TC and HDL-C during the winter. 78”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [78]
In the citing paper
“There is a considerable intra-individual variation in plasma lipids.”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [78]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project
Conroy, R. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00114-3 · Cited by 5,290
Higgins, S. M. F., Macken, A. P., Cullen, W., Saunders, J., Dunne, C. P., & O’Gorman, C. S. (2013) · PubMed · doi:10.34961/9953 · Cited by 4,807
ESC/EAS Guidelines for the management of dyslipidaemias
Reiner, Ž., Catapano, A. L., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr158 · Cited by 3,549
Self-citationGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk
The International Consortium for Blood Pressure Genome-Wide Association Studies (2011) · Nature · doi:10.1038/nature10405 · Cited by 2,033
Self-citationGlobal association of air pollution and heart failure: a systematic review and meta-analysis
Shah, A. S. V., Langrish, J. P., Nair, H., McAllister, D., Hunter, A. L., Donaldson, K., Newby, D. E., & Mills, N. L. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60898-3 · Cited by 1,263
Martins, D., Wolf, M. S., Pan, D., Zadshir, A., Tareen, N. G., Thadhani, R., Felsenfeld, A. J., Levine, B. S., Mehrotra, R., & Norris, K. C. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.11.1159 · Cited by 832
ESC/EAS Guidelines for the management of dyslipidaemias
Catapano, A. L., Reiner, Ž., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.028 · Cited by 706
Effects of Cold Weather on Mortality: Results From 15 European Cities Within the PHEWE Project
Analitis, A., Katsouyanni, K., Biggeri, A., Baccini, M., Forsberg, B., Bisanti, L., Kirchmayer, U., Ballester, F., Cadum, E., Goodman, P., et al. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn266 · Cited by 666
Epidemiological Findings of Seasonal Changes in Mood and Behavior
Kasper, S. F., Wehr, T. A., Bartko, J. J., Gaist, P., & Rosenthal, N. E. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810090065010 · Cited by 642
Cited by
Sorted by citations
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162
Self-citation2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.018 · Cited by 1,582
“This is to some extent due to analytical variation, but is also due to environmental factors such as diet and physical activity, and a seasonal variation, with higher levels of TC and HDL-C during the winter.(78)”
BackgroundEnvironmental Determinants of Cardiovascular Disease
Bhatnagar, A. (2017) · Circulation Research · doi:10.1161/circresaha.117.306458 · Cited by 636
Seasonal variations in cardiovascular disease
Stewart, S., Keates, A. K., Redfern, A., & McMurray, J. J. V. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.76 · Cited by 338
Martí-Soler, H., Gonseth, S., Gubelmann, C., Stringhini, S., Bovet, P., Chen, P., Wojtyniak, B., Paccaud, F. M., Tsai, D.-H., Zdrojewski, T. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113500 · Cited by 156
“However, in a previous study, we showed that hospitalizations for cardiovascular disease also occurred less frequently in summer months [6] and cardiovascular risk factors also showed seasonal variation with increased levels in winter [7].”
BackgroundResultSelf-citationCardiovascular diseases, cold exposure and exercise
Ikäheimo, T. M. (2017) · Temperature · doi:10.1080/23328940.2017.1414014 · Cited by 150
Oxidative Stress in Ischemic Heart Disease
Kibel, A., Lukinac, A. M., Đambić, V., Jurić, I., & Selthofer-Relatić, K. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6627144 · Cited by 155
Obesity trends and risk factors in the South African adult population
Cois, A., & Day, C. (2015) · BMC Obesity · doi:10.1186/s40608-015-0072-2 · Cited by 133
“BMI values were adjusted for month of data collection in the light of previous evidence from population studies showing a significant (albeit small in magnitude) variation in BMI by season (with higher values recorded in winter than in summer), [25, 26] and the observation that the period of data collection differed r…”
MethodStergiou, G. S., Palatini, P., Modesti, P. A., Asayama, K., Asmar, R., Bilo, G., de la Sierra, A., Dolan, E., Head, G., Kario, K., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002341 · Cited by 130
“For DBP, the estimated seasonal variationwas 1.4 and 0.9mmHg in theNorthern and the Southern Hemispheres, respectively, with nadirs occurring in June and November, respectively [11,20–24].”
BackgroundMethodInfluentialYang, J., Zhou, M., Ou, C., Yin, P., Li, M., Tong, S., Gasparrini, A., Liu, X., Li, J., Cao, L., et al. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.02.020 · Cited by 89
Liu, B., & Taioli, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142382 · Cited by 86
Cepeda, M., Koolhaas, C. M., van Rooij, F. J. A., Tiemeier, H. W., Guxens, M., Franco, O. H., & Schoufour, J. D. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.01.016 · Cited by 94
Ponjoan, A., Blanch, J., Alves‐Cabratosa, L., Martí‐Lluch, R., Comas‐Cufí, M., Parramon, D., García-Gil, M., Ramos, R., & Petersen, I. (2017) · Environmental Health · doi:10.1186/s12940-017-0238-0 · Cited by 78
“The lack of association between cardiovascular morbidity and heatwaves can be partially explained by the fact that cardiovascular risk factors tended to be lower in the summer [34, 45].”
BackgroundSelf-citationGrant, W. B., Anouti, F. A., Boucher, B. J., Dursun, E., Gezen‐Ak, D., Jude, E. B., Каронова, Т. Л., & Płudowski, P. (2022) · Nutrients · doi:10.3390/nu14030639 · Cited by 76
“Thomas Wang and colleagues published the first observational study of CVD risk with respect to serum 25(OH)D concentration in a prospective study of participants in the Framingham Offspring Study in 2008 [4].”
BackgroundThe neurobiology of adaptation to seasons: Relevance and correlations in bipolar disorders
Maruani, J., Anderson, G., Étain, B., Lejoyeux, M., Bellivier, F., & Geoffroy, P. A. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1487975 · Cited by 71
“Cholesterol is one of a number of cardiovascular risk factors that shows seasonal variation with mortality (Marti-Soler et al. 2014), with seasonality also linking to increased suicide risk in BD males (Kim et al. 2015).”
BackgroundAverage Temperature, Diurnal Temperature Variation, and Stroke Hospitalizations
Lichtman, J. H., Leifheit-Limson, E. C., Jones, S. B., Wang, Y., & Goldstein, L. B. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.02.037 · Cited by 66
The effect of diurnal temperature range on blood pressure among 46,609 people in Northwestern China
Zheng, S., Zhu, W., Wang, M., Shi, Q., Luo, Y., Miao, Q., Nie, Y., Feng, K., Mi, X., & Bai, Y. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138987 · Cited by 65
The Copenhagen City Heart Study (Østerbroundersøgelsen)
Aguib, Y., & Suwaidi, J. M. S. A. (2015) · Global Cardiology Science and Practice · doi:10.5339/gcsp.2015.33 · Cited by 64
“In another study aiming at the assessment of the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies, cross-sectional data from 24 population based studies from 15 countries, with a total sample size of 237 979 subjects were analysed.(42) CVRFs showed a seasonal pattern charact…”
BackgroundThe first Portuguese National Health Examination Survey (2015): design, planning and implementation
Nunes, B., Barreto, M., Gil, A. P., Kislaya, I., Namorado, S., Antunes, L., Gaio, V., Santos, A. J., Rodrigues, A. P., Santos, J., et al. (2018) · Journal of Public Health · doi:10.1093/pubmed/fdy150 · Cited by 57
Circadian rhythm of blood cardiac troponin T concentration
Fournier, S., Iten, L., Marques-Vidal, P. M., Boulat, O., Bardy, D., Beggah, A., Calderara, R., Morawiec, B., Lauriers, N., Monney, P. A., et al. (2017) · Clinical Research in Cardiology · doi:10.1007/s00392-017-1152-8 · Cited by 57
Self-citationGrant, W. B., Bhattoa, H. P., & Boucher, B. J. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.01.003 · Cited by 52
Perspective: Application of N-of-1 Methods in Personalized Nutrition Research
Potter, T. I. T., Vieira, R., & de Roos, B. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa173 · Cited by 47
Sakamoto, M., Matsutani, D., Minato, S., Tsujimoto, Y., Kayama, Y., Takeda, N., Ichikawa, S., Horiuchi, R., Utsunomiya, K., & Nishikawa, M. (2019) · Diabetes Care · doi:10.2337/dc18-1953 · Cited by 46
Sunlight: For Better or For Worse? A Review of Positive and Negative Effects of Sun Exposure
van der Rhee, H. J., de Vries, E., Coomans, C. P., van de Velde, P., & Coebergh, J. W. W. (2016) · Cancer Research Frontiers · doi:10.17980/2016.156 · Cited by 43
“- 164 appear to be independent predictors of BP (84,85).”
Background2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I. M., Backer, G. D., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Kardiologia Polska · doi:10.5603/kp.2016.0157 · Cited by 48
Temperature and Precipitation Associate With Ischemic Stroke Outcomes in the United States
Chu, S. Y., Cox, M., Fonarow, G. C., Smith, E. E., Schwamm, L. H., Bhatt, D. L., Matsouaka, R., Xian, Y., & Sheth, K. N. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.010020 · Cited by 40
Narita, K., Hoshide, S., & Kario, K. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19494 · Cited by 40
Phung, D. T., Mueller, J. F., Lai, F. Y., O'Brien, J. W., Dang, N., Morawska, L., & Thai, P. K. (2017) · Environmental Research · doi:10.1016/j.envres.2017.03.023 · Cited by 39
“The strong invert association of atenolol consumption and ambient temperature observed in this study (p=0.007) is in agreement with evidence from traditional epidemiological studies about the seasonal variability of cardiovascular risks (Lichtman et al., 2016; Marti-Soler et al., 2014).”
ResultInfluentialGuessous, I. (2015) · BioMed Research International · doi:10.1155/2015/563403 · Cited by 37
“The results have strongly suggested that cardiovascular risk factors present a seasonal pattern, with lower levels occurring during the summer and higher levels during thewinter, suggesting that at least part of the patterningmight be due to changes in air/outdoor temperature, air pollution, and exposure to sunlight a…”
BackgroundSelf-citationSeasonal variation of diet quality in a large middle-aged and elderly Dutch population-based cohort
van der Toorn, J. E., Cepeda, M., Jong, J. C. K., Franco, O. H., Voortman, T., & Schoufour, J. D. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01918-5 · Cited by 36
Seasonal variations in exacerbations and deaths in patients with COPD during the TIOSPIR® trial
Wise, R. A., Calverley, P. M. A., Carter, K., Clerisme-Beaty, E. M., Metzdorf, N., & Anzueto, A. (2018) · International Journal of COPD · doi:10.2147/copd.s148393 · Cited by 35
Ohashi, Y., Katsuta, T., Tani, H., Okabayashi, T., Miyahara, S., & Miyashita, R. (2018) · International Journal of Biometeorology · doi:10.1007/s00484-018-1529-z · Cited by 33
Bramness, J. G., Walby, F. A., Morken, G., & Røislien, J. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv064 · Cited by 32
“The suggested additive Fourier Poisson time-series regression model would also be appropriate for studying other temporal phenomena with a seasonal component, such as infectious diseases (57, 58), cardiovascular diseases (59, 60), cancer (61), psychiatric disorders (62, 63), and other phenomena.”
MethodZhou, X., Lin, H., Zhang, S., Ren, J., Wang, Z., Zhang, Y., Wang, M., & Zhang, Q. (2016) · Journal of clinical lipidology · doi:10.1016/j.jacl.2016.06.009 · Cited by 31
Vitamin D and Cardiovascular Health: A Narrative Review of Risk Reduction Evidence
Grant, W. B., Boucher, B. J., Cheng, R. Z., Płudowski, P., & Wimalawansa, S. J. (2025) · Nutrients · doi:10.3390/nu17132102 · Cited by 30
Школьников, В. М., Klimkin, I., McKee, M., Jdanov, D. A., Galarza, A. A., Németh, L., Тимонин, С. А., Nepomuceno, M. R., Андреев, Е. М., & Leon, D. A. (2022) · SSM - Population Health · doi:10.1016/j.ssmph.2022.101118 · Cited by 29
Seasonal blood pressure variation: implications for cardiovascular risk stratification
Modesti, P. A., Rapi, S., Rogolino, A. A., Tosi, B., & Galanti, G. (2018) · Hypertension Research · doi:10.1038/s41440-018-0048-y · Cited by 29
“In the Northern Hemisphere, estimated seasonal variations were 0.26 kg/m2 for BMI, 0.6 cm for waist circumference, 2.9 mmHg for SBP, 1.4 mmHg for DBP, 0.02 mmol/L for triglycerides, 0.10mmol/L for total cholesterol, 0.01mmol/L for HDL cholesterol, 0.11mmol/L for LDL cholesterol, and 0.07mmol/L for glycemia, which are…”
BackgroundResultInfluentialВладимировна, К. Н., & Galagudza, M. V. (2021) · International Journal of Stroke · doi:10.1177/17474930211006296 · Cited by 30
Goel, H., Shah, K., Kumar, A., Hippen, J. T., & Nadar, S. K. (2022) · Journal of Human Hypertension · doi:10.1038/s41371-022-00707-8 · Cited by 35
“the native climate, such that winter-time BP increase is more pronounced in warmer climates [41, 50, 51].”
BackgroundVersaci, F., Biondi‐Zoccai, G., Giudici, A. D., Mariano, E. G., Trivisonno, A., Sciarretta, S., Valenti, V., Peruzzi, M., Cavarretta, E., Frati, G., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.07.006 · Cited by 28
Lévy, S., Leonard, W. R., Tarskaia, L. A., Klimova, T. M., Fedorova, V. I., Baltakhinova, M. E., & Snodgrass, J. J. (2016) · American Journal of Human Biology · doi:10.1002/ajhb.22879 · Cited by 28
“In support of this hypothesis, previous work across high-latitude populations has identified seasonal patterns in metabolic health indicators, such as body composition, blood pressure, and serum lipids and glucose (Hopstock et al., 2013; Marti-Soler et al., 2014; Rode and Shephard, 1973).”
ResultUnderstanding temporal changes and seasonal variations in glycemic trends using wearable data
Belsare, P. V., Bartolome, A., Stanger, C., & Prioleau, T. (2023) · Science Advances · doi:10.1126/sciadv.adg2132 · Cited by 28
Helicopter Emergency Medical Service (HEMS) Response in Rural Areas in Poland: Retrospective Study
Rzońca, P., Świeżewski, S. P., Jalali, R., Gotlib, J., & Gałązkowski, R. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16091532 · Cited by 26
Yoneyama, K., Nakai, M., Higuma, T., TERAMOTO, K., Watanabe, M., Kaihara, T., Sumita, Y., Miyamoto, Y., Yasuda, S., Ishibashi, Y., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90352-x · Cited by 26
Luo, J., He, G., Xu, Y., Chen, Z., Xu, X., Peng, J., Chen, S., Hu, J., Ji, G., Liu, T., et al. (2021) · BMC Public Health · doi:10.1186/s12889-021-11563-5 · Cited by 29
“A large study included 15 middle and high countries also found that higher FPG among adults was observed in winter than summer in both Northern Hemisphere and Southern Hemisphere [16].”
BackgroundResultAarts, E., Akkerman, A., Altgassen, M., Bartels, R., Beckers, D. G. J., Bevelander, K. E., Bijleveld, E., Davidson, E. N. B., Boleij, A., Bralten, J., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260952 · Cited by 25
Winter Peaks in Heart Failure: An Inevitable or Preventable Consequence of Seasonal Vulnerability?
Stewart, S., Moholdt, T. T., Burrell, L. M., Sliwa, K. S., Mocumbi, A. O., McMurray, J. J. V., Keates, A. K., & Hawley, J. A. (2019) · Cardiac failure review · doi:10.15420/cfr.2018.40.2 · Cited by 24
Nutrition in the spotlight: metabolic effects of environmental light
Versteeg, R. I., Stenvers, D. J., Kalsbeek, A., Bisschop, P. H. L. T., Serlie, M. J. M., & la Fleur, S. E. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000707 · Cited by 25
Biomarker variability and cardiovascular disease residual risk
Simpson, W. G. (2019) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000627 · Cited by 23
“Seasonality is known to affect lipid levels in populations [31].”
BackgroundCold-hearted: A case for cold stress in cancer risk
Bandyopadhayaya, S., Ford, B. M., & Mandal, C. C. (2020) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2020.102608 · Cited by 24
Prodam, F., Zanetta, S., Ricotti, R., Marolda, A., Giglione, E., Monzani, A., Walker, G. E., Rampone, S., Castagno, M., Bellone, S., et al. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.12.032 · Cited by 22
The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases
McClements, L., Annett, S., Yakkundi, A., & Robson, T. (2015) · Current Molecular Pharmacology · doi:10.2174/1874467208666150519115729 · Cited by 22
Cepeda, M., Muka, T., Ikram, M. A., Franco, O. H., & Schoufour, J. D. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01921 · Cited by 22
“Procedures for estimation of the seasonal variation are provided elsewhere (2, 33).”
BackgroundВладимировна, К. Н., Tsyrlin, V. A., & Плисс, М. Г. (2021) · Izvestiya Atmospheric and Oceanic Physics · doi:10.1134/s0001433821100078 · Cited by 21
“In a meta-analysis by Marti-Soler et al. (2014) showed that cardiovascular diseases are more exacerbated in winter than in other seasons.”
BackgroundThe Christmas holidays are immediately followed by a period of hypercholesterolemia
Vedel‐Krogh, S., Kobylecki, C. J., Nordestgaard, B. G., & Langsted, A. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.011 · Cited by 21
UVA and Seasonal Patterning of 56 370 Myocardial Infarctions Across Scotland, 2000–2011
Mackay, D., Clemens, T. L., Hastie, C. E., Cherrie, M. P. C., Dibben, C. J. L., & Pell, J. P. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012551 · Cited by 20
Post-exposure persistence of nitric oxide upregulation in skin cells irradiated by UV-A
Hazell, G., Khazova, M., Cohen, H., Felton, S. J., & Raj, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-13399-4 · Cited by 20
“Support for this effect of sunlight is found in epidemiological studies showing that countries lying closer to the equator, with highest sunlight hours in winter months, present lower cardiovascular incidences than those nearer the Poles, with shortest sunlight hours (22,23).”
BackgroundAre the Levels of Lipid Parameters Associated with Biometeorological Conditions?
Skutecki, R., Cymes, I., Dragańska, E., Glińska‐Lewczuk, K., Buciński, A., Drozdowski, M., & Romaszko, J. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16234636 · Cited by 18
“[4], which indicated seasonal correlations of many cardiovascular risk factors, including higher TC values in wintertime in both hemispheres.”
BackgroundВладимировна, К. Н., & Щеголев, Б. Ф. (2022) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-022-01064-6 · Cited by 17
Владимировна, К. Н., Tsyrlin, V. A., Плисс, М. Г., & Galagudza, M. M. (2022) · The Egyptian Heart Journal · doi:10.1186/s43044-022-00322-5 · Cited by 19
Seasonal variation in plasma lipids and lipases in young healthy humans
Cambras, T., Baena‐Fustegueras, J. A., Pardina, E., Ricart-Jané, D., Rossell, J., Dı́ez-Noguera, A., & Peinado‐Onsurbe, J. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1359618 · Cited by 16
“However, it seems clear that the values that determine the existence of a seasonality of cardiovascular risk factor levels tended to be higher in the winter and lower in the summer months (Marti-Soler et al. 2014).”
BackgroundZeng, W., Yu, M., Mai, W., Zhou, M., Zhou, C., Xiao, Y., Hou, Z., Xu, Y., Liu, T., Hu, J., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111834 · Cited by 17
Enginar, A. Ü., & Kaçar, C. (2019) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2019_096 · Cited by 17
“There are known to be seasonal patterns in some diseases (7–13).”
Kottke, T. E., ANDERSON, J. P., Zillhardt, J. D., Sperl‐Hillen, J. M., O’Connor, P. J., Green, B. B., Williams, R. A., Averbeck, B. M., Stiffman, M. N., Beran, M., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.29098 · Cited by 15
Владимировна, К. Н., Tsyrlin, V. A., & Плисс, М. Г. (2021) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093021030029 · Cited by 15
Meteoropathy: a review on the current state of knowledge
Hoxha, M., & Zappacosta, B. (2023) · Journal of Medicine and Life · doi:10.25122/jml-2023-0097 · Cited by 17
“On the other hand, the secondary form affects patients with chronic diseases, such as cardiovascular and obstructive pulmonary disease [11-14].”
BackgroundSocioeconomic Status Modifies the Seasonal Effect on Blood Pressure
Cois, A., & Ehrlich, R. I. (2015) · Medicine · doi:10.1097/md.0000000000001389 · Cited by 14
“Trigonometric splines are frequently used in epidemiological studies to model seasonal patterns, and they have been previously applied in the study of seasonal variations in blood pressure.(5,12,13) Our specific implementation, including interaction terms for each age category, allowed for the estimation of the magnit…”
MethodResultInfluentialSeasonality of cognitive function in the general population: the Rotterdam Study
Mooldijk, S. S., Licher, S., Vernooij, M. W., Ikram, M. K., & Ikram, M. A. (2021) · GeroScience · doi:10.1007/s11357-021-00485-0 · Cited by 14
Владимировна, К. Н., Tsyrlin, V. A., Плисс, М. Г., & Galagudza, M. M. (2022) · Human Physiology · doi:10.1134/s0362119722030100 · Cited by 13
Seasonal changes in HbA1c values from young to elderly diabetic patients
Bando, H., Kato, Y., Yamashita, H., Yada, S., Tokuhara, S., Tokuhara, H., & Mutsuda, T. (2019) · Journal of Diabetes Metabolic Disorders & Control · doi:10.15406/jdmdc.2019.06.00187 · Cited by 11
Martí-Soler, H., Pommier, C., Bochud, M., Guessous, I., Ponte, B., Pruijm, M. T., Ackermann, D., Ogna, V. F., Paccaud, F. M., Burnier, M., et al. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.06.012 · Cited by 14
“A possible explanation lies in the seasonality of cardiovascular risk factors, which 75 present higher levels in winter than in summer [3].”
BackgroundInfluentialSelf-citationCornélissen, G., Gubin, D. G., Beaty, L. A., & Otsuka, K. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17093083 · Cited by 14
“Several risk factors underlying adverse cardiovascular events such as body mass index, blood pressure, low-density lipoprotein (LDL) cholesterol, triglycerides, and glucose concentrations also follow a circannual rhythm [21].”
BackgroundSeasonal Variation in Demand for Smoking Cessation Treatment and Clinical Outcomes
Veldhuizen, S., Zawertailo, L. A., Ivanova, A., Hussain, S., & Selby, P. L. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa214 · Cited by 13
Владимировна, К. Н., Плисс, М. Г., & Tsyrlin, V. A. (2019) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2019-1-80-93 · Cited by 11
Enhörning, S., Melander, O., Engström, G., Elmståhl, S., Lind, L., Nilsson, P. M., Pihlsgård, M., & Timpka, S. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13489 · Cited by 11
Seasonal Variations of Nutritional Status in Maintenance Hemodialysis Patients
Begović, T. I., Radić, J., Radić, M., Kovačić, V., Šain, M., & Ljutić, D. (2016) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12405 · Cited by 9
Karamercan, M. A., Dündar, Z. D., Ergın, M., van Meer, O. A., Body, R. M., Harjola, V., Verschuren, F., Christ, M., Golea, A. C., Capsec, J., et al. (2020) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-2002-221 · Cited by 9
Seasonal variation in estimated cardiovascular risk in patients with type 2 diabetes
Ciardullo, S., Muraca, E., Cannistraci, R., Manzoni, G., Perra, S., Bianconi, E., Oltolini, A., Zerbini, F., Grassi, G. M., Mancia, G., et al. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.01.022 · Cited by 9
Basic Aspects of Seasonal Cardiovascular Mortality
Фатиховна, А. Г., & Gorbunov, V. M. (2021) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2021-02-01 · Cited by 8
Васильевна, К. А., Lukyanov, М. М., Khudyakov, M. B., Klyashtorny, V. G., Balanova, Y. А., Калинина, А. М., & Boytsov, S. A. (2015) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2014-11-25-30 · Cited by 8
Alpine Skiing as Winter-Time High-Intensity Training
STÖGGL, T. L., Schwarzl, C., Müller, E. E., Nagasaki, M., Stöggl, J., Schönfelder, M., & Niebauer, J. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001289 · Cited by 8
The hazard of rounding Cape Horn: is it changing?
Modesti, P. A. (2014) · Heart · doi:10.1136/heartjnl-2014-306160 · Cited by 8
Владимировна, К. Н., Плисс, М. Г., Galagudza, M. M., & Tsyrlin, V. A. (2020) · Advances in Gerontology · doi:10.1134/s2079057020020095 · Cited by 7
Loader, J., Chan, Y., Hawley, J. A., Moholdt, T. T., McDonald, C. F., Jhund, P. S., Petrie, M. C., McMurray, J. J. V., Scuffham, P., Ramchand, J., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.12.060 · Cited by 7
“Behavioural seasonality has been demonstrated in several studies [27,28],where peaks in alcohol consumption and energy intake (including increases in fat-intake) and troughs in physical activity levels, occur in the cooler months; coinciding with winter peaks in cardiovascular events [20,29,30].”
BackgroundSeasonality as a risk factor for deaths in Parkinson's disease
Fonseca, M. C. M., Sansone, D., Farah, D., FIORINI, A. C., Scorza, C. A., & Scorza, F. A. (2024) · Clinics · doi:10.1016/j.clinsp.2024.100506 · Cited by 7
“[40] In fact, the prevalence of hypertension rises throughout the winter season, [46 − 49] and low temperatures exacerbate hypertension [47,50 − 55] and precipitate cardiovascular events such as stroke, acute myocardial infarction, and heart failure.”
Cold-Induced Hypertension as Life-Environment Disease in Winter: Focus on Data From Japan
Kario, K. (2026) · Hypertension · doi:10.1161/hypertensionaha.125.26518 · Cited by 6
The effect of cold exposure on serum cholesterol is dependent upon ApoE
He, F., Su, W., Wu, R., Li, H., Lou, L., Wu, A., Xie, L., Du, Y., & Wu, S. (2021) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2021.102972 · Cited by 6
Honda, H., Igaki, M., Komatsu, M., & Tanaka, S. (2021) · Endocrines · doi:10.3390/endocrines2020015 · Cited by 7
“, temperature, sun exposure that induces vitamin D synthesis) [16,17], can induce variations in metabolic and vascular function [17,18].”
BackgroundMétéo et saisons influencent-elles notre cœur ?
Gibelin, P. (2015) · La Presse Médicale · doi:10.1016/j.lpm.2015.07.004 · Cited by 6
Dong, Y., Liu, X., Zhao, Y., Chai, Q., Zhang, H., Gao, Y., & Liu, Z. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.692773 · Cited by 6
Influence of meteorological factors on human health
Mirković, A., & Savić, N. (2022) · Sestrinska vizija · doi:10.5937/sestrviz2210017m · Cited by 6
Gül, M., Batur, A. F., Böcü, K., Kaynar, M., Kılıç, Ö., & Göktaş, S. (2021) · Andrologia · doi:10.1111/and.14019 · Cited by 6
Tang, L., Zhang, J., Xu, Y., Xu, T., Yang, Y., & Wang, J. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02840-1 · Cited by 6
“4 mmHg in the Northern and Southern Hemispheres, with the lowest points occurring in June and January, respectively [28].”
BackgroundTesfa, M., Motbainor, A., & Yenesew, M. A. (2025) · Frontiers in Epidemiology · doi:10.3389/fepid.2024.1498203 · Cited by 5
Is the weekend effect true in acute stroke patients at tertiary stroke center?
Räty, S., Martinez‐Majander, N., Suomalainen, O., Sibolt, G., Tiainen, M., Valkonen, K., Sairanen, T., Forss, N., & Curtze, S. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117557 · Cited by 5
COVID-19 Pandemic and Cardiovascular Diseases: Lessons and Prospects
Shlyakhto, E. V., Конради, А. О., Каронова, Т. Л., & Федотов, П. А. (2022) · Herald of the Russian Academy of Sciences · doi:10.1134/s1019331622040098 · Cited by 5
Boytsov, S. A., Lukyanov, М. М., Деев, А. Д., Klyashtorny, V. G., Ivanenko, A. V., Volkova, N. S., Kuznetsov, A. S., Skvortsov, A. S., & Solov’yov, D. V. (2016) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2016-6-34-40 · Cited by 5
Virág, K., & Nyári, T. (2018) · Central European Journal of Public Health · doi:10.21101/cejph.a4928 · Cited by 5
Age-dependent seasonality in the incidence of stroke: A 21-year population-based study
Libruder, C., Yaari, R., Fluss, R., Hershkovitz, Y., Ram, A., Tanné, D., Huppert, A., & Zucker, I. (2024) · European Stroke Journal · doi:10.1177/23969873231223031 · Cited by 4
“20,21 This may lead to seasonal variation in the occurrence of events according to age, and thus hold important epidemiological and practical implications to better understand and reduce the burden of stroke.”
BackgroundThe impact of cold weather on older people and the vital role of community nurses
da Silva, T. M. H. R. (2024) · British Journal of Community Nursing · doi:10.12968/bjcn.2024.0003 · Cited by 4
Metadata
- Authors
- Marti-Soler, H., Gubelmann, C., Aeschbacher, S., Alves, L., Bobak, M., Bongard, V., Clays, E., de Gaetano, G., Di Castelnuovo, A., Elosua, R., Ferrieres, J., Guessous, I., Igland, J., Jørgensen, T., Nikitin, Y., O'Doherty, M. G., Palmieri, L., Ramos, R., Simons, J., Sulo, G., Vanuzzo, D., Vila, J., Barros, H., Borglykke, A., Conen, D., De Bacquer, D., Donfrancesco, C., Gaspoz, J.-M., Giampaoli, S., Giles, G. G., Iacoviello, L., Kee, F., Kubinova, R., Malyutina, S., Marrugat, J., Prescott, E., Ruidavets, J. B., Scragg, R., Simons, L. A., Tamosiunas, A., Tell, G. S., Vollenweider, P., & Marques-Vidal, P.
- Affiliations
- Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland
- Institute of Social and Preventive Medicine (CH)
- University Hospital of Basel (CH)
- Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal
- Department of Epidemiology and Public Health, University College London, London, UK
- Inserm (FR)
- Ghent University (BE)
- Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Pozzilli (IS), Italy
- Cardiovascular and Genetic Epidemiology Research Group (ULEC-EGEC), Inflammatory and Cardiovascular Disease Programme (RICAD), IMIM, Barcelona, Spain
- Department of Epidemiology, UMR 1027- INSERM, Toulouse University—CHU Toulouse, Toulouse, France
- University Hospital of Geneva (CH)
- University of Bergen (NO)
- University of Copenhagen (DK)
- Laboratory of Internal Medicine, Institute of Internal Medicine, Siberian Branch RAMS, Novosibirsk, Russia
- UKCRC Centre of Excellence for Public Health, Queens University of Belfast, Belfast, UK
- Istituto Superiore di Sanità (IT)
- Universitat de Girona (ES)
- UNSW Sydney (AU)
- Centro di Prevenzione Cardiovascolare, ASS 4 ‘Medio Friuli’, Udine, Italy
- Hospital del Mar Research Institute (ES)
- Universidade do Porto (PT)
- Capital Region of Denmark (DK)
- Department of Public Health, Ghent University, Ghent, Belgium
- Cancer Council Victoria (AU)
- Istituto Neurologico Mediterraneo (IT)
- Queen's University Belfast (GB)
- Centre for Health Monitoring, National Institute of Public Health, Prague, Czech Republic
- Novosibirsk State Medical University (RU)
- Frederiksberg Hospital (DK)
- University of Auckland (NZ)
- Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania
- Department of Internal Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland
- Corresponding author
- Marques-Vidal, Pedro
- ORCID
- Gubelmann, Cédric
- Aeschbacher, Stefanie
- Bongard, Vanina
- Clays, Els
- Guessous, Idris
- Igland, Jannicke
- Jørgensen, Torben
- Palmieri, Luigi
- Ramos, Rafel
- Sulo, Gerhard
- Vanuzzo, Diego
- Vila, Joan
- Barros, Henrique
- Donfrancesco, Chiara
- Giles, Graham G
- Iacoviello, Licia
- Kee, Frank
- Malyutina, Sofia
- Marrugat, Jaume
- Prescott, Eva
- Scragg, Robert
- Simons, Leon A
- Tell, Grethe S
- Marques-Vidal, Pedro
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2014-05-30
- Volume
- 100
- Issue
- 19
- Pages
- 1517-1523
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W2140020569
- Cited by
- 151
- References
- 37
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 17 · 2023: 7 · 2022: 18 · 2021: 23 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 2
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- IRIS (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Lithuanian University of Health Sciences (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Science Foundation (33CSCO-122661)
- John D. and Catherine T. MacArthur Foundation (064947/Z/01/Z)
- Pfizer
- GlaxoSmithKline (3200B0–105993, 33CSCO-122661, 3200B0-118308)
- Velux Stiftung
- Hjerteforeningen
- Universität Basel (PP00P3_133681)
- Sundhed og Sygdom, Det Frie Forskningsråd (396414, 209057)
- Wellcome Trust (064947/Z/01/Z, 081081/Z/06/Z, 209057, 081081, 081081/Z)
- Universitätsspital Basel
- Agence Nationale de la Recherche (396414, 209057)
- Institut National de la Santé et de la Recherche Médicale (209057, 396414)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (122661, 124087, 33CSCO, 118308, 133681, 105993, 3200B0, 139468, 108315, FN 33CSC0-)
- Fonds De La Recherche Scientifique - FNRS (3200B0-105993, 3200B0-118308, 33CSCO-122661)
- Fonds Wetenschappelijk Onderzoek (209057, 396414)
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Istituto Superiore di Sanità
- Schweizerische Herzstiftung
- China Scholarship Council
- Ministerio de Ciencia e Innovación
- Region Hovedstaden
- Hôpitaux Universitaires de Genève
- Institut de Veille Sanitaire
- Chinese Society of Clinical Oncology
- Canton de Genève
- Vlaamse regering
- Pfizer Foundation
- Forsknings- og Innovationsstyrelsen
- Medical Research Council (MR/K023241/1, 396414, 209057)
- National Health and Medical Research Council (396414, 251533, 209057)
- Cancer Council Victoria (209057, 396414)
- Health Research Council of New Zealand
- Danish Agency for Science and Higher Education
- Fundação para a Ciência e a Tecnologia (PTDC/SAU-ESA/108315/2008)
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III (RD12/0042)
- European Regional Development Fund (RD12/0042)
- National Institute on Aging (R01AG023522)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- seasonal variation, cardiovascular risk factors, body mass index, waist circumference, blood pressure, lipoprotein cholesterol, triglycerides, blood glucose, hemispheric differences, cardiovascular mortality
- MeSH terms
- Adult, Aged, Aged, 80 and over, Blood Pressure, Cardiovascular Diseases, Cold Temperature, Cross-Sectional Studies, Data Interpretation, Statistical, Europe, Female, Humans, Lipids, Male, Middle Aged, Mortality, New Zealand, Risk Factors, Seasons, Triglycerides, Body Mass Index, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
