Haemodynamic and anatomic progression of aortic stenosis
Open accessAbstract
Background: Aortic valve stenosis (AS) is a progressive disease, but the impact of baseline AS haemodynamic or anatomic severity on AS progression remains unclear. Methods: In 149 patients (104 mild AS, 36 moderate AS and 9 severe AS) enrolled in 2 ongoing prospective cohorts (COFRASA/GENERAC), we evaluated AS haemodynamic severity at baseline and yearly, thereafter, using echocardiography (mean pressure gradient (MPG)) and AS anatomic severity using CT (degree of aortic valve calcification (AVC)). Results: After a mean follow-up of 2.9±1.0 years, mean MGP increased from 22±11 to 30±16 mm Hg (+3±3 mm Hg/year), and mean AVC from 1108±891 to 1640±1251 AU (arbitrary units) (+188±176 AU/year). Progression of AS was strongly related to baseline haemodynamic severity (+2±3 mm Hg/year in mild AS, +4±3 mm Hg/year in moderate AS and +5±5 mm Hg/year in severe AS (p=0.01)), and baseline haemodynamic severity was an independent predictor of haemodynamic progression (p=0.0003). Annualised haemodynamic and anatomic progression rates were significantly correlated (r=0.55, p<0.0001), but AVC progression rate was also significantly associated with baseline haemodynamic severity (+141±133 AU/year in mild AS, +279±189 AU/year in moderate AS and +361±293 AU/year in severe AS, p<0.0001), and both baseline MPG and baseline AVC were independent determinants of AVC progression (p<0.0001). Conclusions: AS progressed faster with increasing haemodynamic or anatomic severity. Our results suggest that a medical strategy aimed at preventing AVC progression may be useful in all subsets of patients with AS including those with severe AS and support the recommended closer follow-up of patients with AS as AS severity increases. Clinical trial registration: COFRASA (clinicalTrial.gov number NCT 00338676) and GENERAC (clinicalTrial.gov number NCT00647088 ).
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Prior studies have demonstrated that CT-calcium scoring is a robust and reproducible imaging technique, with excellent diagnostic accuracy for identifying severe aortic stenosis.
“Prior studies have demonstrated that CT‐calcium scoring is a robust and reproducible imaging technique, with excellent diagnostic accuracy for identifying severe AS. 10 , 11 , 12 , 14 , 25 , 26”
From Grading of Aortic Valve Calcification Severity and Risk Stratification in Aortic Stenosis (2024) · cites this paper as [11]
The MSCT measurements section (page unavailable) says CT assessment of aortic-valve calcification is accurate and reproducible, and reports low observer variability. The Introduction describes calcium scoring as complementary for assessing stenosis severity, but the paper does not establish excellent diagnostic accuracy for identifying severe aortic stenosis specifically. (LLM, conf=0.86)
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Cites
Burden of valvular heart diseases: a population-based study
Nkomo, V. T., Gardin, J. M., Skelton, T. N., Gottdiener, J. S., Scott, C. G., & Enriquez-Sarano, M. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69208-8 · Cited by 4,881 · see citing works
Self-citationGuidelines on the management of valvular heart disease (version 2012)
Authors/Task Force Members, Vahanian, A., Alfieri, O., Andreotti, F., Antunes, M. J., Barón-Esquivias, G., Baumgartner, H., Borger, M. A., Carrel, T. P., De Bonis, M., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs109 · Cited by 3,559 · see citing works
Self-citationIung, B. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00201-x · Cited by 3,530 · see citing works
Guidelines on the management of valvular heart disease (version 2012)
Authors Task Force Members, Vahanian, A. S., Alfieri, O., Andreotti, F., Antunes, M. J., Barón‐Esquivias, G., Baumgartner, H., Borger, M. A., Carrel, T. P., Bonis, M. D., et al. (2012) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezs455 · Cited by 2,000 · see citing works
Self-citationIntensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis
Rossebø, A. B., Pedersen, T. R., Boman, K., Brudi, P., Chambers, J. B., Egstrup, K., Gerdts, E., Gohlke-Bärwolf, C., Holme, I., Kesäniemi, Y. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804602 · Cited by 1,644 · see citing works
Otto, C. M., Kuusisto, J., Reichenbach, D. D., Gown, A. M., & O’Brien, K. D. (1994) · Circulation · doi:10.1161/01.cir.90.2.844 · Cited by 1,315 · see citing works
A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis
Cowell, S. J., Newby, D. E., Prescott, R. J., Bloomfield, P., Reid, J., Northridge, D. B., & Boon, N. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043876 · Cited by 1,146 · see citing works
Bone Formation and Inflammation in Cardiac Valves
Mohler, E. R., Gannon, F. H., Reynolds, C. A., Zimmerman, R. A., Keane, M. G., & Kaplan, F. S. (2001) · Circulation · doi:10.1161/01.cir.103.11.1522 · Cited by 1,053 · see citing works
Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice
Baumgartner, H., Hung, J., Bermejo, J., Chambers, J. B., Evangelista, A., Griffin, B. P., Iung, B., Otto, C. M., Pellikka, P. A., & Quinones, M. (2009) · European Journal of Echocardiography · doi:10.1093/ejechocard/jen303 · Cited by 967 · see citing works
Chan, K. L., Teo, K., Dumesnil, J. G., Ni, A., & Tam, J. (2010) · Circulation · doi:10.1161/circulationaha.109.900027 · Cited by 815 · see citing works
Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction
Otto, C. M., & Prendergast, B. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1313875 · Cited by 631 · see citing works
The Complex Nature of Discordant Severe Calcified Aortic Valve Disease Grading
Clavel, M.-A., Messika-Zeitoun, D., Pibarot, P., Aggarwal, S. R., Malouf, J., Araoz, P. A., Michelena, H. I., Cueff, C., Larose, E., Capoulade, R., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.1621 · Cited by 569 · see citing works
Self-citationCueff, C., Serfaty, J.-M., Cimadevilla, C., Laissy, J.-P., Himbert, D., Tubach, F., Duval, X., Iung, B., Enriquez-Sarano, M., Vahanian, A., et al. (2011) · Heart · doi:10.1136/hrt.2010.198853 · Cited by 385 · see citing works
Self-citationMessika–Zeitoun, D., Aubry, M.-C., Détaint, D., Bielak, L. F., Peyser, P. A., Sheedy, P. F., Turner, S. T., Breen, J. F., Scott, C. G., Tajik, A. J., et al. (2004) · Circulation · doi:10.1161/01.cir.0000135469.82545.d0 · Cited by 383 · see citing works
Self-citationPathogenesis of Calcific Aortic Valve Disease
O’Brien, K. D. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000227513.13697.ac · Cited by 294 · see citing works
Aggarwal, S. R., Clavel, M.-A., Messika-Zeitoun, D., Cueff, C., Malouf, J., Araoz, P. A., Mankad, R., Michelena, H., Vahanian, A., & Enriquez-Sarano, M. (2013) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.112.980052 · Cited by 280 · see citing works
Self-citationHemodynamic progression of aortic stenosis in adults assessed by doppler echocardiography
Otto, C. M., Pearlman, A. S., & Gardner, C. L. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90590-1 · Cited by 247 · see citing works
Messika–Zeitoun, D., Bielak, L. F., Peyser, P. A., Sheedy, P. F., Turner, S. T., Nkomo, V. T., Breen, J. F., Maalouf, J. F., Scott, C. G., Tajik, A. J., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000255952.47980.c2 · Cited by 206 · see citing works
Self-citationAortic Valve Calcification on Computed Tomography Predicts the Severity of Aortic Stenosis
Cowell, S. J., Newby, D. E., Burton, J. D., White, A. C., Northridge, D. B., Boon, N. A., & Reid, J. (2003) · Clinical Radiology · doi:10.1016/s0009-9260(03)00184-3 · Cited by 148 · see citing works
Aortic Valve Calcification as a Marker for Aortic Stenosis Severity: Assessment on 16-MDCT
Koos, R., Mahnken, A. H., Sinha, A. M., Wildberger, J. E., Hoffmann, R., & Kühl, H. P. (2004) · American Journal of Roentgenology · doi:10.2214/ajr.183.6.01831813 · Cited by 142 · see citing works
Stage-Related Effect of Statin Treatment on the Progression of Aortic Valve Sclerosis and Stenosis
Antonini‐Canterin, F., Hîrşu, M., Popescu, B. A., Leiballi, E., Piazza, R., Pavan, D., Ginghină, C., & Nicolosi, G. L. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.04.056 · Cited by 85 · see citing works
Morgan-Hughes, G. J., Owens, P. E., Roobottom, C. A., & Marshall, A. J. (2003) · Heart · doi:10.1136/heart.89.10.1191 · Cited by 79 · see citing works
Leye, M. M. C. B. O., Brochet, É., Lepage, L., Cueff, C., Boutron, I., Détaint, D., Hyafil, F., Iung, B., Vahanian, A. S., & Messika–Zeitoun, D. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2009.02.007 · Cited by 64 · see citing works
Self-citationHekimian, G., Boutten, A., Flamant, M., Duval, X., Dehoux, M., Benessiano, J., Huart, V., Dupré, T., Berjeb, N., Tubach, F., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs450 · Cited by 53 · see citing works
Self-citationde Monchy, C. C., Lepage, L., Boutron, I., Leye, M. M. C. B. O., Détaint, D., Hyafil, F., Brochet, É., Iung, B., Vahanian, A. S., & Messika–Zeitoun, D. (2008) · European Journal of Echocardiography · doi:10.1093/ejechocard/jen301 · Cited by 37 · see citing works
Self-citationSverdlov, A. L., Ngo, D. T. M., Chan, W. P. A., Chirkov, Y. Y., Gersh, B. J., McNeil, J. J., & Horowitz, J. D. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs171 · Cited by 35 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Rajamannan NM, Evans FJ, Aikawa E, et al. National Heart, Lung and Blood Institute (NHLBI) Working Group on Calcific Aotic Stenosis. 2010. http:// wwwnhlbinihgov/meetings/workshops/cashtm
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Computed Tomography Aortic Valve Calcium Scoring in Patients With Aortic Stenosis
Pawade, T., Clavel, M.-A., Tribouilloy, C., Dreyfus, J., Mathieu, T., Tastet, L., Renard, C., Gun, M., Jenkins, W. S. A., Macron, L., et al. (2018) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.117.007146 · Cited by 397 · see citing works
Self-citationTastet, L., Capoulade, R., Clavel, M.-A., Larose, É., Shen, M., Dahou, A., Arsenault, M., Mathieu, P., Bédard, É., Dumesnil, J. G., et al. (2017) · European Heart Journal – Cardiovascular Imaging · doi:10.1093/ehjci/jew013 · Cited by 100 · see citing works
Self-citationImpact of Aortic Valve Calcification and Sex on Hemodynamic Progression and Clinical Outcomes in AS
Tastet, L., Enriquez-Sarano, M., Capoulade, R., Malouf, J., Araoz, P. A., Shen, M., Michelena, H. I., Larose, É., Arsenault, M., Bédard, É., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.02.037 · Cited by 70 · see citing works
Self-citationGrading of Aortic Valve Calcification Severity and Risk Stratification in Aortic Stenosis
Tastet, L., Ali, M., Pibarot, P., Capoulade, R., Øvrehus, K. A., Arsenault, M., Haujir, A., Bédard, É., Diederichsen, A. C. P., Dahl, J. S., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.035605 · Cited by 29 · see citing works
Self-citationEffects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis
Trenkwalder, T., Nelson, C. P., Musameh, M. D., Mordi, I. R., Kessler, T., Pellegrini, C., Debiec, R., Rheude, T., Lazovic, V., Zeng, L., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.11.094 · Cited by 18 · see citing works
- Authors
- Nguyen, V., Cimadevilla, C., Estellat, C., Codogno, I., Huart, V., Benessiano, J., Duval, X., Pibarot, P., Clavel, M. A., Enriquez-Sarano, M., Vahanian, A., & Messika-Zeitoun, D.
- Affiliations
- Inserm (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Ressources Biologique, Assistance Publique—Hôpitaux de Paris, Bichat Hospital, Paris, France
- Department of Medicine, Québec Heart and Lung Institute, Laval University, Québec city, Québec, Canada
- Mayo Clinic (US)
- Department of Cardiology, Assistance Publique—Hôpitaux de Paris, Bichat Hospital, Paris, France
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2015-02-05
- Volume
- 101
- Issue
- 12
- Pages
- 943-947
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W1986785505
- Cited by
- 81
- References
- 26
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 4 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 5 · 2016: 11 · 2015: 5
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed (publishedVersion)
- Corpus Université Laval (Université Laval) (submittedVersion)
- Funders
- Assistance publique-Hôpitaux de Paris
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Keywords
- aortic stenosis, disease progression, mean pressure gradient, aortic valve calcification, follow-up interval
- MeSH terms
- Aged, Aortic Valve, Aortic Valve Stenosis, Blood Pressure, Calcinosis, Female, Follow-Up Studies, Hemodynamics, Humans, Male, Severity of Illness Index, Tomography, X-Ray Computed, Echocardiography, Doppler, Disease Progression
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