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Cited by 287

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Sex differences in cardiovascular ageing

Open access
Merz, Allison A, Cheng, Susan·2016·Heart

Abstract

Despite recent progress in identifying and narrowing the gaps in cardiovascular outcomes between men and women, general understanding of how and why cardiovascular disease presentations differ between the sexes remains limited. Sex-specific patterns of cardiac and vascular ageing play an important role and, in fact, begin very early in life. Differences between the sexes in patterns of age-related cardiac remodelling are associated with the relatively greater prevalence in women than in men of heart failure with preserved ejection fraction. Similarly, sex variation in how vascular structure and function change with ageing contributes to differences between men and women in how coronary artery disease manifests typically or atypically over the adult life course. Both hormonal and non-hormonal factors underlie sex differences in cardiovascular ageing and the development of age-related disease. The midlife withdrawal of endogenous oestrogen appears to augment the age-related increase in cardiovascular risk seen in postmenopausal compared with premenopausal women. However, when compared with intrinsic biological differences between men and women that are present throughout life, this menopausal transition may not be as substantial an actor in determining cardiovascular outcomes.

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Crossref · 10.1136/heartjnl-2015-308769

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Metadata

Authors
Merz, A. A., & Cheng, S.
Venue
Heart
Publisher
BMJ
Published
2016-02-25
Volume
102
Issue
11
Pages
825-831
ISSN
  • 1355-6037 (ISSN-L)
  • 1468-201X
OpenAlex
W2336201514
Cited by
287
References
66
FWCI
16.63
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Sex differences in cardiovascular ageing. https://app.cochat.ai/papers/10.1136/heartjnl-2015-308769
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Merz, A. A., & Cheng, S. (2016). Sex differences in cardiovascular ageing. Heart. https://doi.org/10.1136/heartjnl-2015-308769

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.