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Treatment of hypertrophic obstructive cardiomyopathy with verapamil.
Open accessAbstract
Twenty-two patients with hypertrophic obstructive cardiomyopathy were treated with the calcium inhibitor, verapamil, which was administered in a mean oral dose of 480 mg per day. After an average of 15 months of treatment (4 to 24 months), the QRS amplitude in the electrocardiogram was significantly reduced from 4.2 to 3.8 mV. Heart volume calculated from chest x-ray films in the supine position decreased significantly from 858 to 766 ml per 1.73 m2. In 10 patients, follow-up heart catheterisation showed a decrease in left ventricular muscle mass in 7 patients and a slight increase in 3 patients. Coronary artery diameter decreased in 7 patients, increased in 1, and was unchanged in 2. The reduction in coronary artery diameter is considered to be a consequence of a reduced heart muscle mass. From all available clinical data it is concluded that verapamil treatment is superior to beta-blocker therapy.
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Cited by
Olivotto, I., Oreziak, A., Barriales-Villa, R., Abraham, T. P., Masri, A., Garcia-Pavia, P., Saberi, S., Lakdawala, N. K., Wheeler, M. T., Owens, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31792-x · Cited by 1,296
Maron, B. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00479-2 · Cited by 698
McKenna, W., Deanfield, J., Faruqui, A., England, D., Oakley, C., & Goodwin, J. (1981) · The American Journal of Cardiology · doi:10.1016/0002-9149(81)90535-x · Cited by 630
Bonow, R. O., Rosing, D. R., Bacharach, S. L., Green, M. V., Kent, K. M., Lipson, L. C., Maron, B. J., Leon, M. B., & Epstein, S. E. (1981) · Circulation · doi:10.1161/01.cir.64.4.787 · Cited by 393
Metadata
- Authors
- Kaltenbach, M., Hopf, R., Kober, G., Bussmann, W. D., Keller, M., & Petersen, Y.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1979-07-01
- Volume
- 42
- Issue
- 1
- Pages
- 35-42
- ISSN
- 1355-6037 (ISSN-L)
- OpenAlex
- W2152663914
- Cited by
- 213
- References
- 0
- FWCI
- 17.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kaltenbach, M., Hopf, R., Kober, G., Bussmann, W. D., Keller, M., & Petersen, Y. (1979). Treatment of hypertrophic obstructive cardiomyopathy with verapamil. Heart. https://doi.org/10.1136/hrt.42.1.35
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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