The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy.
Abstract
Verapamil improves exercise capacity in patients with hypertrophic cardiomyopathy (HCM), but its mechanism of action are unknown. We examined the effects of oral verapamil (320-480 mg/day) on resting left ventricular (LV) systolic and diastolic function in patients with HCM. High-temporal-resolution time-activity curves from gated technetium-99m radionuclide angiograms were analyzed before and after verapamil therapy in 40 patients, of whom 16 were also studied during propranolol therapy (80-960 mg/day). All but one patient had normal or supranormal systolic function, but 70% had evidence of diastolic dysfunction, defined as peak LV filling rate (PFR) less than 2.5 end-diastolic volumes (EDV)/sec or time to PFR greater than 80 msec. Verapamil did not change LV ejection fraction, peak ejection rate or ejection time, but did increase PFR (control 3.3 +/- 1.0 EDV/sec, verapamil 4.1 +/- 1.1 EDV/sec; p less than 0.001) and reduce time to PFR (control 187 +/- 56 msec, verapamil, 159 +/- 34 msec; p less than 0.001). Only 30% of patients had evidence of diastolic dysfunction during verapamil. In contrast, propranolol did not change LV ejection fraction, PFR or time to PFR, but did prolong ejection time and reduce peak ejection rate. Thus, LV diastolic filling is abnormal in a high percentage of patients with HCM, and verapamil normalizes or improves these abnormalities without altering systolic function. This mechanism may contribute to the clinical improvement of many HCM patients during verapamil therapy.
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Cites
Borer, J. S., Bacharach, S. L., Green, M. V., Kent, K. M., Epstein, S. E., Johnston, G. S., & Mack, B. (1977) · New England Journal of Medicine · doi:10.1056/nejm197704142961503 · Cited by 773
Self-citationBonow, R. O., Bacharach, S. L., Green, M. V., Kent, K. M., Rosing, D. R., Lipson, L. C., Leon, M. B., & Epstein, S. E. (1981) · Circulation · doi:10.1161/01.cir.64.2.315 · Cited by 573
Self-citationLeft ventricular compliance: Mechanisms and clinical implications
Gaasch, W. H., Levine, H. J., Quinones, M. A., & Alexander, J. K. (1976) · The American Journal of Cardiology · doi:10.1016/s0002-9149(76)80015-x · Cited by 456
Diastolic Properties of the Left Ventricle
Grossman, W., & McLAURIN, L. P. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-3-316 · Cited by 435
Hanrath, P., Mathey, D. G., Siegert, R., & Bleifeld, W. (1980) · The American Journal of Cardiology · doi:10.1016/0002-9149(80)90214-3 · Cited by 400
Campeau, L., Lespérance, J., Hermann, J., Corbara, F., Grondin, C. M., & Bourassa, M. G. (1979) · Circulation · doi:10.1161/01.cir.60.2.1 · Cited by 250
Rosing, D. R., Kent, K. M., Maron, B. J., & Epstein, S. E. (1979) · Circulation · doi:10.1161/01.cir.60.6.1208 · Cited by 246
Self-citationRosing, D. R., Kent, K. M., Borer, J. S., Seides, S. F., Maron, B. J., & Epstein, S. E. (1979) · Circulation · doi:10.1161/01.cir.60.6.1201 · Cited by 230
Self-citationTreatment of hypertrophic obstructive cardiomyopathy with verapamil.
Kaltenbach, M., Hopf, R., Kober, G., Bussmann, W. D., Keller, M., & Petersen, Y. (1979) · Heart · doi:10.1136/hrt.42.1.35 · Cited by 213
Left ventricular relaxation and filling in hypertrophic cardiomyopathy. An echocardiographic study.
Sanderson, J. E., Traill, T. A., Sutton, M. G., Brown, D. J., Gibson, D. G., & Goodwin, J. F. (1978) · Heart · doi:10.1136/hrt.40.6.596 · Cited by 180
Cited by
Hypertrophic Cardiomyopathy: A Systematic Review
Maron, B. J. (2002) · JAMA · doi:10.1001/jama.287.10.1308 · Cited by 2,224
Self-citationGersh, B. J., Maron, B. J., Bonow, R. O., Dearani, J. A., Fifer, M. A., Link, M. S., Naidu, S. S., Nishimura, R. A., Ommen, S. R., Rakowski, H., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318223e2bd · Cited by 2,104
Self-citation2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy
Gersh, B. J., Maron, B. J., Bonow, R. O., Dearani, J. A., Fifer, M. A., Link, M. S., Naidu, S. S., Nishimura, R. A., Ommen, S. R., Rakowski, H., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.011 · Cited by 1,276
Self-citationOmmen, S. R., Ho, C. Y., Asif, I. M., Balaji, S., Burke, M. A., Day, S. M., Dearani, J. A., Epps, K. C., Evanovich, L., Ferrari, V. A., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001250 · Cited by 807
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy
Ommen, S. R., Mital, S., Burke, M. A., Day, S. M., Deswal, A., Elliott, P., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.08.045 · Cited by 643
Metadata
- Authors
- Bonow, R. O., Rosing, D. R., Bacharach, S. L., Green, M. V., Kent, K. M., Lipson, L. C., Maron, B. J., Leon, M. B., & Epstein, S. E.
- Venue
- Circulation
- Published
- 1981-10
- Volume
- 64
- Issue
- 4
- Pages
- 787-796
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1984678068
- Cited by
- 393
- References
- 13
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. https://app.cochat.ai/papers/10.1161/01.cir.64.4.787
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- Bonow, R. O., Rosing, D. R., Bacharach, S. L., Green, M. V., Kent, K. M., Lipson, L. C., Maron, B. J., Leon, M. B., & Epstein, S. E. (1981). Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. Circulation. https://doi.org/10.1161/01.cir.64.4.787
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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