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THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSA

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Dunnill, M. S.·1960·Journal of Clinical Pathology

Abstract

The pathological features of 20 cases dying in status asthmaticus have been studied. In gross sections the lungs showed no emphysema, but mucus plugs in the air passages and focal areas of collapse were outstanding features. Five cases showed cystic bronchiectasis which was of a similar distribution to the focal areas of collapse, occurring in the upper lobes as commonly as in the lower lobes. Histologically, shedding of the ciliated bronchial mucosal cells was prominent and this is attributed to a transudation of oedema fluid from the submucosa. Areas of regeneration of the mucosa, with the presence of simple stratified epithelium, were seen frequently. The loss of the ciliated respiratory epithelium and the transudation of oedema fluid into the bronchial lumen, with interference with the action of the remaining ciliated cells, are considered to be the essential factors in the failure of clearance of the bronchial secretions in asthma. It is postulated that bronchospasm plays little or no part in the shedding of the bronchial mucosa or in the pathogenesis of the asthmatic attack.

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Metadata

Authors
Dunnill, M. S.
Venue
Journal of Clinical Pathology
Publisher
BMJ
Published
1960-01
Volume
13
Issue
1
Pages
27-33
ISSN
  • 0021-9746 (ISSN-L)
  • 1472-4146
OpenAlex
W2074326572
Cited by
1,012
References
0
FWCI
1.78
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSA. https://app.cochat.ai/papers/10.1136/jcp.13.1.27
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Dunnill, M. S. (1960). THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSA. Journal of Clinical Pathology. https://doi.org/10.1136/jcp.13.1.27

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.