Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis
Open accessAbstract
The role of steroid treatment in drug-induced acute interstitial nephritis (DI-AIN) is controversial. We performed a multicenter retrospective study to determine the influence of steroids in 61 patients with biopsy-proven DI-AIN, 52 of whom were treated with steroids. The responsible drugs were antibiotics (56%), non-steroidal anti-inflammatory drugs (37%) or other drugs. The final serum creatinine was significantly lower in treated patients while almost half of untreated patients remained on chronic dialysis. Among treated patients, over half showed a complete recovery of baseline renal function, whereas the rest remained in renal failure. There were no significant initial differences between these two subgroups in terms of duration or dosage of steroids. After withdrawal of the presumed causative drug, we found that when steroid treatment was delayed (by an average of 34 days) renal function did not return to baseline levels compared to those who received steroid treatment within the first 2 weeks after withdrawal of the offending agent. We found a significant correlation between the delay in steroid treatment and the final serum creatinine. Renal biopsies, including three patients who underwent a second biopsy, showed a progression of interstitial fibrosis related to the delay in steroid treatment. Our study shows that steroids should be started promptly after diagnosis of DI-AIN to avoid subsequent interstitial fibrosis and an incomplete recovery of renal function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Antibiotic-related AIN may require use of alternative antibiotic drugs along with application of an immunosuppressant.
“during the case of an antibiotic-related AIN, clinicians may require the use of alternative antibiotic drugs along with the application of an immunosuppressant [3, 6, 16, 17]”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [17]
Cites
Acute interstitial nephritis: clinical features and response to corticosteroid therapy
Clarkson, M. R. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh485 · Cited by 343 · see citing works
Bhaumik, S. K., Kher, V., Arora, P., Rai, P. K., Singhal, M., Gupta, A., Pandey, R., & Sharma, R. K. (1996) · Renal Failure · doi:10.3109/08860229609052779 · Cited by 67 · see citing works
Acute renal failure in patients with drug-induced acute interstitial nephritis
Koselj, M., Kveder, R., Bren, A. F., & Rott, T. (1993) · Renal Failure · doi:10.3109/08860229309065575 · Cited by 48 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Brahmer, J. R., Abu-Sbeih, H., Ascierto, P. A., Brufsky, J., Cappelli, L. C., Cortazar, F. B., Gerber, D. E., Hamad, L., Hansen, E., Johnson, D. B., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002435 · Cited by 917 · see citing works
Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors
Cortazar, F. B., Marrone, K. A., Troxell, M. L., Ralto, K. M., Hoenig, M. P., Brahmer, J. R., Le, D. T., Lipson, E. J., Glezerman, I. G., Wolchok, J. D., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.04.008 · Cited by 649 · see citing works
“The efficacy of glucocorticoids in the treatment of AIN remains controversial due to conflicting observational studies and the absence of a randomized trial.(17,18) In our cohort, 9 of 10 patients with CPI-induced AIN treated with glucocorticoids had complete or partial recovery of renal function, whereas neither of t…”
BackgroundThompson, J. A., Schneider, B. J., Brahmer, J., Andrews, S., Armand, P., Bhatia, S., Budde, L. E., Costa, L., Davies, M., Dunnington, D., et al. (2019) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2019.0013 · Cited by 570 · see citing works
Praga, M., & González, E. (2010) · Kidney International · doi:10.1038/ki.2010.89 · Cited by 507 · see citing works
Self-citationClinical features and outcomes of immune checkpoint inhibitor-associated AKI: a multicenter study
Cortazar, F. B., Kibbelaar, Z. A., Glezerman, I. G., Abudayyeh, A., Mamlouk, O., Motwani, S. S., Murakami, N., Herrmann, S. M., Manohar, S., Shirali, A. C., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019070676 · Cited by 407 · see citing works
Drug-induced acute interstitial nephritis
Perazella, M. A., & Markowitz, G. S. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.71 · Cited by 378 · see citing works
Drug-Induced Acute Kidney Injury
Perazella, M. A., & Rosner, M. H. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11290821 · Cited by 357 · see citing works
Biopsy-proven acute interstitial nephritis, 1993-2011: a case series
Muriithi, A. K., Leung, N., Valeri, A. M., Cornell, L. D., Sethi, S., Fidler, M. E., & Nasr, S. H. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.04.027 · Cited by 337 · see citing works
Levey, A. S., & James, M. T. (2017) · Annals of Internal Medicine · doi:10.7326/aitc201711070 · Cited by 575 · see citing works
Marik, P. (2015) · Springer eBooks · doi:10.1007/978-3-319-11020-2_41 · Cited by 244 · see citing works
Current concepts and advances in biomarkers of acute kidney injury
Wen, Y., & Parikh, C. R. (2021) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2021.1879000 · Cited by 229 · see citing works
Acute kidney injury in patients treated with immune checkpoint inhibitors
Gupta, S., Short, S., Sise, M. E., Prosek, J. M., Madhavan, S. M., Soler, M. J., Ostermann, M., Herrmann, S. M., Abudayyeh, A., Anand, S., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003467 · Cited by 239 · see citing works
Acute Kidney Injury in the Elderly
Abdel-Kader, K., & Palevsky, P. (2009) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.04.001 · Cited by 199 · see citing works
Role of Oxidative Stress in Drug-Induced Kidney Injury
Hosohata, K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111826 · Cited by 191 · see citing works
“Many studies show that there is no correlation between the type of offending drug and the histologic findings [43,44].”
BackgroundTubulointerstitial Nephritis: Diagnosis, Treatment and Monitoring
Joyce, E. L., Glasner, P., Ranganathan, S., & Swiatecka-Urban, A. (2016) · Pediatric nephrology (Berlin, West) · doi:10.1007/s00467-016-3394-5 · Cited by 157 · see citing works
The 6R’s of drug induced nephrotoxicity
Awdishu, L., & Mehta, R. L. (2017) · BMC Nephrology · doi:10.1186/s12882-017-0536-3 · Cited by 163 · see citing works
Hsu, C.-Y. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012030222 · Cited by 151 · see citing works
Praga, M., Sevillano, A., Auñón, P., & González, E. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu326 · Cited by 147 · see citing works
Self-citationSpanish Guidelines for Diagnosis, Management, Treatment and Prevention of DRESS syndrome.
Cabañas, R., Ramírez, E., Sendagorta, E., Alamar, R., Barranco, R., Blanca-López, N., Doña, I., Fernández, J., Garcia-Nunez, I., García-Samaniego, J., et al. (2020) · Journal of investigational allergology & clinical immunology · doi:10.18176/jiaci.0480 · Cited by 147
Acute interstitial nephritis – a reappraisal and update
Raghavan, R., & Eknoyan, G. (2014) · Clinical Nephrology · doi:10.5414/cn108386 · Cited by 141 · see citing works
Fernandez-Juarez, G., Perez, J. V., Caravaca-Fontán, F., Quintana, L., Shabaka, A., Rodriguez, E., Gadola, L., de Lorenzo, A., Cobo, M. A., Oliet, A., et al. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01390118 · Cited by 133 · see citing works
Self-citationDrug-Induced Acute Interstitial Nephritis
Moledina, D. G., & Perazella, M. A. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07630717 · Cited by 133 · see citing works
Beta-Lactams Toxicity in the Intensive Care Unit: An Underestimated Collateral Damage?
Roger, C., & Louart, B. (2021) · Microorganisms · doi:10.3390/microorganisms9071505 · Cited by 120 · see citing works
“Delayed corticosteroid administration may be associated with a poorer renal prognosis, suggesting that this therapy should be considered at an early stage and the need for randomized studies in this context [54,56].”
BackgroundProton pump inhibitors and acute kidney injury: a nested case–control study
Klepser, D., Collier, D., & Cochran, G. (2013) · BMC Nephrology · doi:10.1186/1471-2369-14-150 · Cited by 118 · see citing works
Fluid, electrolyte and acid–base disorders associated with antibiotic therapy
Zietse, R., Zoutendijk, R., & Hoorn, E. J. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.17 · Cited by 104 · see citing works
Fattori, V., Borghi, S. M., Guazelli, C. F., Giroldo, A. C., Crespigio, J., Bussmann, A. J. C., Coelho-Silva, L., Ludwig, N., Mazzuco, T., Casagrande, R., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2016.12.039 · Cited by 104 · see citing works
Increased prevalence of acute tubulointerstitial nephritis.
Goicoechea, M., Rivera, F., & López-Gómez, J. (2013) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gfs143 · Cited by 96 · see citing works
Self-citationRenal toxicity of therapeutic drugs
John, R., & Herzenberg, A. M. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.058271 · Cited by 93 · see citing works
IgG4-related disease and the kidney
Cortazar, F., & Stone, J. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.95 · Cited by 93
Renal Biopsy in Very Elderly Patients: Data from the Spanish Registry of Glomerulonephritis
Verde, E., Quiroga, B., Rivera, F., & López-Gómez, J. (2012) · American Journal of Nephrology · doi:10.1159/000336307 · Cited by 86 · see citing works
Renal involvement in primary Sjögren's syndrome.
Evans, R., Zdebik, A., Ciurtin, C., & Walsh, S. (2015) · Rheumatology · doi:10.1093/rheumatology/kev223 · Cited by 84 · see citing works
Immune Checkpoint Inhibitor Nephrotoxicity: Update 2020
Gupta, S., Cortazar, F. B., Riella, L. V., & Leaf, D. E. (2020) · Kidney360 · doi:10.34067/kid.0000852019 · Cited by 96 · see citing works
Moledina, D. G., Obeid, W., Smith, R. N., Rosales, I., Sise, M. E., Moeckel, G., Kashgarian, M., Kuperman, M., Campbell, K. N., Lefferts, S., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168950 · Cited by 80 · see citing works
“Discovery cohort (Yale) Consensus among adjudicating pathologists Majority of adjudicating pathologists Clinical nephrologist after biopsy Clinical biopsy report 204 249 242 210 31 (15) 52 (21) 75 (31) 37 (17) AIN 60 (16–1103) 66 (20–504) 35 (13–312) 45 (7–638) Not AIN 11 (5–45) 12 (5–46) 11 (5–60) 11 (5–43) 2.”
Koda, R., Watanabe, H., Tsuchida, M., Iino, N., Suzuki, K., Hasegawa, G., Imai, N., & Narita, I. (2018) · BMC Nephrology · doi:10.1186/s12882-018-0848-y · Cited by 77 · see citing works
Acute tubulointerstitial nephritis
Ulinski, T., Sellier-Leclerc, A.-L., Tudorache, E., Bensman, A., & Aoun, B. (2012) · Pediatric Nephrology · doi:10.1007/s00467-011-1915-9 · Cited by 75 · see citing works
“have shown a favourable response to steroid therapy in drug-induced AIN, and early treatment initiation was considered beneficial, probably because of decreased fibrinogenesis in the interstitium [59].”
BackgroundDiclofenac induced gastrointestinal and renal toxicity is alleviated by thymoquinone treatment.
Aycan, İ., Elpek, Ö., Akkaya, B., Kıraç, E., Tuzcu, H., Kaya, S., Coskunfirat, N., & Aslan, M. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.06.038 · Cited by 73
Clinical Evidence of Acute Mesoamerican Nephropathy.
Fischer, R., Mandayam, S., Chavarría, D., Vangala, C., Nolan, M., Garcia, L. L., Palma, L., García, F., Garcia-Trabanino, R., & Murray, K. (2017) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.17-0260 · Cited by 66 · see citing works
Acute kidney injury due to acyclovir
Yildiz, Ç., Ozsurekci, Y., Gucer, S., Cengiz, A., & Topaloğlu, R. (2013) · CEN Case Reports · doi:10.1007/s13730-012-0035-0 · Cited by 66
“[20] showed that, in biopsy-proven DI-AN patients, final creatinine levels were found to be better (lower) in the steroid administered group than in the nonsteroid (control) group.”
BackgroundLong-term outcome in biopsy-proven acute interstitial nephritis treated with steroids
Prendecki, M., Tanna, A., Salama, A. D., Tam, F. W. K., Cairns, T., Taube, D., Cook, H. T., Ashby, D., Duncan, N. D., & Pusey, C. D. (2016) · Clinical Kidney Journal · doi:10.1093/ckj/sfw116 · Cited by 63 · see citing works
“[22] described a benefit from steroid treatment.”
Acute Kidney Injury Recognition in Low- and Middle-Income Countries
Cerdá, J., Mohan, S., García-García, G., Jha, V., Samavedam, S., Gowrishankar, S., Bagga, A., Chakravarthi, R., & Mehta, R. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.04.009 · Cited by 63 · see citing works
Clinical outcome and occurrence of uveitis in children with idiopathic tubulointerstitial nephritis
Jahnukainen, T., Ala-Houhala, M., Karikoski, R., Kataja, J., Saarela, V., & Nuutinen, M. (2011) · Pediatric nephrology (Berlin, West) · doi:10.1007/s00467-010-1698-4 · Cited by 62 · see citing works
Facing the Challenge of Drug-Induced Acute Interstitial Nephritis
Álamo, B. S., Cases‐Corona, C., & Juarez, G. M. F. (2022) · The Nephron journals/Nephron journals · doi:10.1159/000525561 · Cited by 71 · see citing works
Acute tubulointerstitial nephritis in Scotland.
Valluri, A., Hetherington, L., McQuarrie, E., Fleming, S., Kipgen, D., Geddes, C., Mackinnon, B., & Bell, S. (2015) · QJM : monthly journal of the Association of Physicians · doi:10.1093/qjmed/hcu236 · Cited by 56 · see citing works
“Some retrospective analyses have observed no difference in short-term outcomes,(6) with others suggesting that early corticosteroid administration (within 7 days of diagnosis) can improve the recovery of renal function, decreasing the risk of chronic kidney disease.(7) It has been suggested that delayed corticosteroid…”
BackgroundResultGranulomatous interstitial nephritis
Shah, S., Carter-Monroe, N., & Atta, M. (2015) · Clinical Kidney Journal · doi:10.1093/ckj/sfv053 · Cited by 55
“Patients with NSAID-induced GIN often have higher levels of proteinuria (nephrotic range at times) and less eosinophilia [5, 10].”
BackgroundManohar, S., Ghamrawi, R., Chengappa, M., Goksu, B. N. B., Kottschade, L., Finnes, H. D., Dronca, R., Leventakos, K., Herrmann, J., & Herrmann, S. M. (2020) · Kidney360 · doi:10.34067/kid.0000152019 · Cited by 52 · see citing works
Lin, J. S., Mamlouk, O., Selamet, U., Tchakarov, A. S., Glass, W. F., Sheth, R. A., Layman, R. M., Dadu, R., Abdel‐Wahab, N., Abdelrahim, M., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1877415 · Cited by 66 · see citing works
The Invisible Threat of Non-steroidal Anti-inflammatory Drugs for Kidneys
Clavé, S., Rousset-Rouvière, C., Daniel, L., & Tsimaratos, M. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00520 · Cited by 49 · see citing works
“Two retrospective studies concluded that steroids improve renal function and reduce the risk of CKD (15, 17), but the published treatment protocols are unclear, with seemingly random variations in steroid dosages and treatment durations.”
BackgroundResultInfluentialDifferential Diagnosis of Glomerular Disease: A Systematic and Inclusive Approach
Hebert, L. A., Parikh, S. M., Prosek, J. M., Nádasdy, T., & Rovin, B. H. (2013) · American Journal of Nephrology · doi:10.1159/000354390 · Cited by 4,391 · see citing works
Drug induced acute interstitial nephritis
Basturk, T., Hasbal, N. B., Koç, Y., Isleem, M., Caglayan, F. B., & Unsal, A. (2016) · SiSli Etfal Hastanesi Tip Bulteni / The Medical Bulletin of Sisli Hospital · doi:10.5350/semb.20160902010424 · Cited by 48 · see citing works
“In many studies in the literature, the duration of glucocorticoid therapy varies between 8-12 weeks (5,16,25).”
BackgroundInfluentialUrine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis
Moledina, D. G., Wilson, F. P., Kukova, L., Obeid, W., Luciano, R., Kuperman, M., Moeckel, G. W., Kashgarian, M., Perazella, M. A., Cantley, L. G., et al. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa169 · Cited by 47 · see citing works
Acute tubulointerstitial nephritis, treatment with steroid and impact on renal outcomes
RAZA, M. N., HADID, M., KEEN, C. E., BINGHAM, C., & SALMON, A. H. (2012) · Nephrology · doi:10.1111/j.1440-1797.2012.01648.x · Cited by 46 · see citing works
“One study has emphasized the importance of timing of the initiation of steroids in ATIN: better renal outcome with early steroid introduction.(14) In our cohort, steroids were used in the majority of cases.”
BackgroundEosinophilia and Kidney Disease: More than Just an Incidental Finding?
Gauckler, P., Shin, J., Mayer, G., & Kronbichler, A. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120529 · Cited by 45 · see citing works
Avasare, R. S. (2019) · Nephrology Secrets · doi:10.1016/b978-0-323-47871-7.00054-x · Cited by 43 · see citing works
Acute tubulointerstitial nephritis following treatment with exenatide
Nandakoban, H., Furlong, T., & Flack, J. (2013) · Diabetic Medicine · doi:10.1111/j.1464-5491.2012.03738.x · Cited by 40 · see citing works
Chiba, S., Tsuchiya, K., Sakashita, H., Ito, E., & Inase, N. (2013) · Internal medicine · doi:10.2169/internalmedicine.52.0634 · Cited by 40 · see citing works
“20 (4-35) clinical features fever, chills 6 (75 %) digestive symptoms 2 (25 %) edema 3 (38 %) shock 1 (13 %) urinalysis proteinuria 8 (100 %) proteinuria over 3.”
Preventable risk factors for acute kidney injury in patients undergoing cardiac surgery.
Arora, P., Kolli, H., Nainani, N., Nader, N., & Lohr, J. (2012) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2012.03.001 · Cited by 39
Molitoris, B. (2012) · doi:10.1016/b978-1-4377-1604-7.00122-6 · Cited by 39
Acute kidney injury in interstitial nephritis
Caravaca-Fontán, F., Fernández-Juárez, G., & Praga, M. (2019) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000654 · Cited by 39 · see citing works
Self-citationSuspected piperacillin‐tazobactam induced nephrotoxicity in the pediatric oncology population
Pratt, J. A., Stricherz, M. K., Verghese, P., & Burke, M. J. (2014) · Pediatric Blood & Cancer · doi:10.1002/pbc.24720 · Cited by 37
“observed in patients with AIN [9].”
Prednisone in the treatment of tubulointerstitial nephritis in children
Jahnukainen, T., Saarela, V., Arikoski, P., Ylinen, E., Rönnholm, K., Ala-Houhala, M., & Nuutinen, M. (2013) · Pediatric nephrology (Berlin, West) · doi:10.1007/s00467-013-2476-x · Cited by 37 · see citing works
“The authors showed that early initiation of the treatment was considered beneficial, probably because of decreased fibrinogenesis in the interstitium [9].”
BackgroundResultInfluentialTubulointerstitial nephritis and cancer chemotherapy: update on a neglected clinical entity.
Airy, M., Raghavan, R., Truong, L., & Eknoyan, G. (2013) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gft241 · Cited by 36 · see citing works
Lee, M. D., Seethapathy, H. S., Strohbehn, I. A., Zhao, S. H., Boland, G. M., Fadden, R. M., Sullivan, R. J., Reynolds, K. L., & Sise, M. E. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002292 · Cited by 42 · see citing works
Moss, J., Parry, C. M., Holt, R. C. L., & McWilliam, S. J. (2022) · European journal of medical research · doi:10.1186/s40001-022-00687-y · Cited by 36 · see citing works
“The evidence behind the use of steroids in DI-AIN is mixed, but there are reports suggesting early treatment with steroids is beneficial [8, 10].”
BackgroundNSAIDs and Nephrotic Syndrome.
Mérida, E., & Praga, M. (2019) · American Society of Nephrology. Clinical Journal · doi:10.2215/cjn.08090719 · Cited by 34
Self-citationNonsteroidal antiinflammatory drugs, cyclooxygenase-2, and the kidneys.
Rahman, S., & Malcoun, A. (2014) · Primary Care · doi:10.1016/j.pop.2014.09.001 · Cited by 34 · see citing works
Drug-induced acid-base disorders
Kitterer, D., Schwab, M. G., Alscher, M. D., Braun, N., & Latus, J. (2014) · Pediatric Nephrology · doi:10.1007/s00467-014-2958-5 · Cited by 58 · see citing works
“Mechanisms of acute kidney failure due to tubular necrosis and interstitial nephritis caused by antibiotics are beyond the scope of this review and are reviewed elsewhere [21, 22].”
BackgroundImmune checkpoint inhibitors and acute kidney injury
Zhou, P., Gao, Y., Kong, Z., Wang, J., Si, S., Han, W., Li, J., Lv, Z., & Wang, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1353339 · Cited by 33 · see citing works
Rifampicin-induced nephrotoxicity in a tuberculosis patient
Beebe, A., Seaworth, B., & Patil, N. (2015) · Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · doi:10.1016/j.jctube.2015.09.001 · Cited by 32 · see citing works
Miao, J., & Herrmann, S. M. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad109 · Cited by 31 · see citing works
“…study of 61 patients with biopsy-proven drug-induced AIN (mostly on antibiotics and NSAIDs), serum creatinine was lower in those treated with steroids; therefore, prompt treatment after diagnosis of AIN would avoid subsequent interstitial fibrosis and an incomplete recovery of renal function [93].”
BackgroundHosohata, K., Inada, A., Oyama, S., & Iwanaga, K. (2018) · Advances in Nephropathy · doi:10.5772/intechopen.79348 · Cited by 31
“In the treatment of drug-induced acute interstitial nephritis, we may consider steroid therapy after early withdrawal of drugs (within 2 weeks), when kidney disorder hangover occurs under the discontinuation of the suspected drug [20].”
BackgroundRamachandran, R., Kumar, K., Nada, R., Jha, V., Gupta, K., & Kohli, H. (2015) · Indian Journal of Nephrology · doi:10.4103/0971-4065.147766 · Cited by 31 · see citing works
Giullian, J. A., Cavanaugh, K., & Schaefer, H. (2010) · Clinical Transplantation · doi:10.1111/j.1399-0012.2009.01129.x · Cited by 31
“While we do not have historical data with which to compare, we postulate that if steroids are protective against drug-induced AIN, the occurrence of this hypersensitivity reaction may increase as more transplant centers move away from routine use of glucocorticoids.”
ResultInfluentialTucci, M., Passarelli, A. M., Todisco, A., Mannavola, F., Stucci, L. S., D’Oronzo, S., Rossini, M., Taurisano, M., Gesualdo, L., & Silvestris, F. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919875549 · Cited by 32 · see citing works
Adverse effects of drugs on the kidney.
Bartoli, E. (2016) · European journal of internal medicine · doi:10.1016/j.ejim.2015.12.001 · Cited by 30
“drawal, prednisone administration [25], continuous follow-up of renal function and clinical conditions.”
BackgroundMethodCefepime induced acute interstitial nephritis – a case report
Mac, K., Chavada, R., Paull, S., Howlin, K., & Wong, J. (2015) · BMC Nephrology · doi:10.1186/s12882-015-0004-x · Cited by 30 · see citing works
“While some retrospective and uncontrolled studies have shown benefit of early administration of corticosteroids in preventing interstitial fibrosis, consistent benefits have not been observed in others [24,25].”
ResultRenal dysfunction in end-stage liver disease and post-liver transplant.
Sampaio, M., Martin, P., & Bunnapradist, S. (2014) · Clinical Liver Disease · doi:10.1016/j.cld.2014.05.003 · Cited by 30 · see citing works
Diagnosing acute interstitial nephritis: considerations for clinicians
Nussbaum, E. Z., & Perazella, M. A. (2019) · Clinical Kidney Journal · doi:10.1093/ckj/sfz080 · Cited by 29 · see citing works
“Two subsequent studies found that eosinophilia was present in 36% [17] and 34% [18] of biopsy-proven cases of AIN.”
BackgroundShimamura, Y., Watanabe, S., Maeda, T., Abe, K., Ogawa, Y., & Takizawa, H. (2021) · Clinical and Experimental Nephrology · doi:10.1007/s10157-020-02008-1 · Cited by 37 · see citing works
“While a guideline recommends glucocorticoid therapy [27], the results of previous observational studies are controversial [28, 29].”
ResultTreatment of Drug-Induced Acute Tubulointerstitial Nephritis
Moledina, D. G., & Perazella, M. A. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12001018 · Cited by 36 · see citing works
A Case Series of Acute Kidney Injury During Anti-tuberculosis Treatment
Sakashita, K., Murata, K., Takahashi, Y., Yamamoto, M., Oohashi, K., Sato, Y., Kitazono, M., Wada, A., & Takamori, M. (2018) · Internal medicine · doi:10.2169/internalmedicine.0813-18 · Cited by 28 · see citing works
“Although the use of steroids for AIN remains controversial (12, 13), one study clearly showed that the early administration of steroids resulted in a higher rate of successful renal function recovery after the development of AIN (14).”
BackgroundAcid‐suppressive drugs and risk of kidney disease: A systematic review and meta‐analysis
Qiu, T.-T., Zhou, J., & Zhang, C. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14157 · Cited by 28 · see citing works
Mizushima, I., Yamamoto, M., Inoue, D., Nishi, S., Taniguchi, Y., Ubara, Y., Matsui, S., Yasuno, T., Nakashima, H., Takahashi, H., et al. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1175-y · Cited by 28 · see citing works
The use of gallium-67 scintigraphy in the diagnosis of acute interstitial nephritis
Graham, F., Lord, M., Froment, D., Cardinal, H., & Bollée, G. (2015) · Clinical Kidney Journal · doi:10.1093/ckj/sfv129 · Cited by 27 · see citing works
“such as fever, rash or eosinophilia are present in only 25–35% of patients with drug-induced AIN, making the clinical diagnosis often difficult [1, 5].”
BackgroundManagement of nonimmediate hypersensitivity reactions to drugs.
Roujeau, J., Haddad, C., Paulmann, M., & Mockenhaupt, M. (2014) · Immunology and allergy clinics of North America · doi:10.1016/j.iac.2014.04.012 · Cited by 27
Borghi, S. M., Fattori, V., Ruiz‐Miyazawa, K. W., Bertozzi, M. M., Lourenco-Gonzalez, Y., Tatakihara, R. I., Bussmann, A. J. C., Mazzuco, T., Casagrande, R., & Verri, W. (2018) · Life Science · doi:10.1016/j.lfs.2018.07.038 · Cited by 26
Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury
Cocchiaro, P., Fox, C. P., Tregidgo, N., Howarth, R., Wood, K. M., Situmorang, G. R., Pavone, L. M., Sheerin, N., & Moles, A. (2016) · Scientific Reports · doi:10.1038/srep27112 · Cited by 29 · see citing works
Urinary eosinophils in AIN: farewell to an old biomarker?
Perazella, M., & Bomback, A. (2013) · American Society of Nephrology. Clinical Journal · doi:10.2215/cjn.08620813 · Cited by 26 · see citing works
Long Non-coding RNA: An Emerging Contributor and Potential Therapeutic Target in Renal Fibrosis
Xia, W., He, Y., Gan, Y., Zhang, B., Dai, G., Ru, F., Jiang, Z., Chen, Z., & Chen, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.682904 · Cited by 25
“Many diseases are associated with RF development, including obstructive kidney disease, chronic glomerulonephritis, chronic pyelonephritis, systemic lupus erythematosus nephropathy, and hereditary nephropathies, such as Alport syndrome, diabetic nephropathy (DN), hypertensive nephropathy, and drug-induced nephropathy…”
BackgroundWente-Schulz, S., Aksenova, M., Awan, A., Ambarsari, C., Becherucci, F., Emma, F., Fila, M., Francisco, T., Gokce, I., Gülhan, B., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-047059 · Cited by 25 · see citing works
Sustained Tubulointerstitial Inflammation in Kidney with Severe Leptospirosis
Tanaka, K., Tanabe, K., Nishii, N., Takiue, K., Sugiyama, H., & Wada, J. (2017) · Internal medicine · doi:10.2169/internalmedicine.56.8084 · Cited by 25
“Furthermore, a recent report suggested that a small percentage of patients who survived acute leptospirosis had a persistently abnormal renal function consistent with early-stage CKD over a three-year follow-up period.”
BackgroundInfluentialPantoprazole-induced acute interstitial nephritis
Klassen, S., Krepinsky, J., & Prebtani, A. (2013) · Canadian Medical Association Journal · doi:10.1503/cmaj.120954 · Cited by 25 · see citing works
“5–1 mg/kg daily) over 4–6 weeks has been suggested.(2,7) The most recent retrospective multicentre study examining steroid use in druginduced acute interstitial nephritis confirmed by biopsy found that patients not given steroid therapy (n = 9) had significantly higher creatinine levels at the end of the follow-up per…”
BackgroundInfluentialAcute and Chronic Tubulointerstitial Nephritis of Rheumatic Causes
Oliva-Dámaso, N., Oliva-Dámaso, E., & Payán, J. (2018) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2018.06.009 · Cited by 26 · see citing works
Gupta, S., Mistry, K., Alikhan, F. M., Mejia, S. M., Sadarangani, S., Cao, A., Wells, S. L., Koval, E., Liang, C., Ortega, J. L., et al. (2025) · Kidney International · doi:10.1016/j.kint.2025.05.029 · Cited by 23 · see citing works
El-Maadawy, W. H., Hassan, M., Abdou, R., Eldine, R. S., Aboushousha, T., El-Tanbouly, N., & El-sayed, A. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.103817 · Cited by 23 · see citing works
Rifampicin-associated acute renal failure and hemolysis: a rather uncommon but severe complication
Manika, K., Tasiopoulou, K., Vlogiaris, L., Lada, M., Papaemmanouil, S., Zarogoulidis, K., & Kioumis, I. (2013) · Renal Failure · doi:10.3109/0886022x.2013.815567 · Cited by 23 · see citing works
“The administration of steroid treatment in patients with druginduced AIN is a matter of debate.(11,16,17) Previous reports did not support the routine administration of steroids in the management of AIN since they were not found to decrease the risk of chronic renal failure.”
BackgroundResultJoaquim, A. I., Mendes, G. E., Ribeiro, P. F. F., Baptista, M., & Burdmann, E. (2010) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gfq152 · Cited by 23 · see citing works
Increased prevalence of acute interstitial nephritis: more disease or simply more detection?
Bomback, A., & Markowitz, G. (2013) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gfs318 · Cited by 23 · see citing works
Effect of steroids and relevant cytokine analysis in acute tubulointerstitial nephritis
Yun, D., Jang, M.-J., An, J. N., Lee, J. P., Kim, D. K., Chin, H. J., Kim, Y. S., Lee, D.-S., & Han, S. S. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1277-2 · Cited by 22 · see citing works
Tureyen, A., Demirel, H., Demirkapi, E. N., Eryavuz, A. M., & Ince, S. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17968 · Cited by 22 · see citing works
“8 Therefore, new therapeutic agents are needed to mitigate both NSAID-induced gastrointestinal damage and renal damage caused by glucocorticoid therapy.”
BackgroundDiagnóstico diferencial de la insuficiencia renal aguda
Galeano, C., Rodríguez, N., & Liaño, F. (2010) · doi:10.3265/nefroplus.pre2010.jul.10548 · Cited by 22
Self-citation
- Authors
- González, E., Gutiérrez, E., Galeano, C., Chevia, C., de Sequera, P., Bernis, C., Parra, E. G., Delgado, R., Sanz, M., Ortiz, M., Goicoechea, M., Quereda, C., Olea, T., Bouarich, H., Hernández, Y., Segovia, B., & Praga, M.
- Affiliations
- Hospital Universitario 12 De Octubre (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Hospital Universitario La Paz (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Ruber Internacional (ES)
- Hospital Universitario de Getafe (ES)
- Hospital Universitario Severo Ochoa (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Corresponding author
- Praga, M.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 73
- Issue
- 8
- Pages
- 940-946
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2128802116
- Cited by
- 466
- References
- 0
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 32 · 2023: 23 · 2022: 32 · 2021: 34 · 2020: 30 · 2019: 38 · 2018: 27 · 2017: 28 · 2016: 23 · 2015: 28 · 2014: 23 · 2013: 18 · 2012: 23
- FWCI
- 16.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Nephrotoxicity and Medicinal Plants
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- drug-induced acute interstitial nephritis, corticosteroid therapy, renal function recovery, interstitial fibrosis, nonsteroidal anti-inflammatory drugs, serum creatinine, dialysis dependence, renal biopsy
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Biopsy, Creatinine, Drug Administration Schedule, Female, Humans, Kidney, Male, Middle Aged, Nephritis, Interstitial, Retrospective Studies, Steroids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
