Muscle fibre type changes in hypothyroid myopathy.
Open accessAbstract
Changes in muscle fibre type in hypothyroid myopathy were studied by serial percutaneous needle biopsy of vastus lateralis before and during treatment with L-thyroxine. A type II fibre atrophy and loss was found, which correlated with the clinical and biochemical evidence of a myopathy. The type II fibre atrophy was corrected by L-thyroxine but type II fibre loss was still apparent in severely myopathic patients up to two years after starting treatment. The pathogenesis and significance of type II fibre atrophy and loss are discussed in relation to prognosis.
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Hypothyroidism produces a lower type-II fiber percentage in male and female patients compared with healthy patients.
“Hypothyroidism produces a lower type-II fiber percentage in male and female patients compared with healthy patients (63).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [63]
Hypothyroid females appear to have a higher proportion of type-II fibers compared with hypothyroid males; however, type-II fiber atrophy occurs in hypothyroid female patients but not in males.
“Hypothyroid females appear to have a higher proportion of type-II fibers compared with hypothyroid males; however, type-II fiber atrophy occurs in hypothyroid female patients but not in males (63).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [63]
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Cites
Data on the distribution of fibre types in thirty-six human muscles
Johnson, M. A., Polgar, J., Weightman, D., & Appleton, D. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90023-3 · Cited by 2,200 · see citing works
THE SPECIFICITY OF THE HISTOCHEMICAL METHOD FOR ADENOSINE TRIPHOSPHATAS
Padykula, H. A., & Herman, E. (1955) · Journal of Histochemistry & Cytochemistry · doi:10.1177/3.3.170 · Cited by 1,201 · see citing works
The histographic analysis of human muscle biopsies with regard to fiber types
Brooke, M. H., & Engel, W. K. (1969) · Neurology · doi:10.1212/wnl.19.3.221 · Cited by 399 · see citing works
The histographic analysis of human muscle biopsies with regard to fiber types
Brooke, M. H., & Engel, W. K. (1969) · Neurology · doi:10.1212/wnl.19.6.591 · Cited by 264 · see citing works
Edström, L. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90104-8 · Cited by 222 · see citing works
The histographic analysis of human muscle biopsies with regard to fiber types
Brooke, M. H., & Engel, W. K. (1969) · Neurology · doi:10.1212/wnl.19.4.378 · Cited by 175 · see citing works
Reciprocal Relationship of Phosphorylase and Oxidative Enzymes in Skeletal Muscle
Dubowitz, V., & Pearse, A. G. E. (1960) · Nature · doi:10.1038/185701a0 · Cited by 168 · see citing works
A STUDY OF THE ANKLE JERK IN MYXEDEMA*
Lambert, E. H., Underdahl, L. O., Beckett, S. B., & MEDEROS, L. O. (1951) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-11-10-1186 · Cited by 146 · see citing works
Atrophy of Skeletal Muscle in Patients With Cushing's Syndrome
Pleasure, D. E., Walsh, G. O., & Engel, W. K. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480200024002 · Cited by 114 · see citing works
Selective atrophy of red muscle fibres in the quadriceps in long-standing knee-joint dysfunction
Edström, L. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90105-x · Cited by 106 · see citing works
Hayashi, M., & Freiman, D. G. (1966) · Journal of Histochemistry & Cytochemistry · doi:10.1177/14.8.577 · Cited by 103 · see citing works
Serum Creatine Phosphokinase Activity in Altered Thyroid States
Graig, F. A., & Smith, J. C. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-6-723 · Cited by 95 · see citing works
Myxedema neuropathy and myopathy
Nickel, S. N., Frame, B., Bebin, J., et al. (1961) · Neurology · doi:10.1212/wnl.11.2.125 · Cited by 86 · see citing works
PERCUTANEOUS NEEDLE-BIOPSY OF SKELETAL MUSCLE IN DIAGNOSIS AND RESEARCH
Edwards, R. H. T. (1971) · The Lancet · doi:10.1016/s0140-6736(71)92165-9 · Cited by 78 · see citing works
Åström, K., Kugelberg, E., & MULLER, R. (1961) · Archives of Neurology · doi:10.1001/archneur.1961.00450170010002 · Cited by 74 · see citing works
Serum enzymes in diseases of the thyroid gland
Griffiths, P. D. (1965) · Journal of Clinical Pathology · doi:10.1136/jcp.18.5.660 · Cited by 68 · see citing works
Fessel, W. J. (1968) · Annals of the Rheumatic Diseases · doi:10.1136/ard.27.6.590 · Cited by 65 · see citing works
Percutaneous needle-biopsy of skeletal muscle in diagnosis and research
Edwards, R. H. T. (1971) · The Lancet · doi:10.1016/s0140-6736(71)80137-x · Cited by 59 · see citing works
Autoimmunity in the pathogenesis of muscle disease
Fessel, W. J., & Raas, M. C. (1968) · Neurology · doi:10.1212/wnl.18.11.1137 · Cited by 23 · see citing works
Electromyographic findings in adults with myxedema: report of 16 cases.
Rr, O., Schumacher, O. P., & NELSON, P. A. (1960) · PubMed · Cited by 12 · see citing works
Engel, W. K. (1996) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Dubowitz, V. and Brooke, M. H. (1973). Muscle Biopsy: A Modern Approach. W. B. Saunders, London.
- Ramsay, I. (1974). Muscular abnormalities ofhypothyroidism In Thyroid Disease and Muscle Dysfunction, Ch. 4, pp. 126-171. Heinemann, London.
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Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition
Haizlip, K. M., Harrison, B. C., & Leinwand, L. A. (2015) · Physiology · doi:10.1152/physiol.00024.2014 · Cited by 521 · see citing works
- Authors
- McKeran, R. O., Slavin, G., Andrews, T. M., Ward, P., & Mair, W. G.
- Affiliations
- Northwick Park Hospital (GB)
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 1975-08
- Volume
- 28
- Issue
- 8
- Pages
- 659-663
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- PMC
- PMC475797
- OpenAlex
- W2116249196
- Cited by
- 87
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- hypothyroid myopathy, muscle fiber type, levothyroxine, thyroid hormone replacement, vastus lateralis, prognosis, muscle biopsy
- MeSH terms
- Adult, Aged, Biopsy, Needle, Female, Humans, Hypothyroidism, Male, Middle Aged, Muscles, Muscular Diseases, Prognosis, Thyroxine
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