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Immunophenotype of multinucleated and mononuclear cells in giant cell lesions of bone and soft tissue
Open accessAbstract
AIMS: To compare the antigenic phenotype of giant cells in giant cell lesions of bone and soft tissue with that of osteoclasts and macrophage polykaryons. METHODS: Formalin fixed, paraffin wax embedded sections of 106 giant cell lesions, 19 granulomatous, and 14 osteoclast containing lesions were immuno-histochemically stained for leucocyte common antigen (LCA), CD68, and HLA-DR. RESULTS: Osteoclasts and giant cells of giant cell tumour of bone and giant cell reparative granuloma could be distinguished by their generalised absence of HLA-DR reaction from macrophage polykaryons and giant cells in other giant cell lesions of bone and soft tissue. Staining for LCA, CD68, and HLA-DR was useful in distinguishing reactive histiocytic giant cells and osteoclasts from tumour giant cells. CONCLUSIONS: A panel of macrophage associated antigens should be diagnostically useful in differentiating the histological nature of giant cells in various giant cell lesions of bone and soft tissue.
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“Foreign body giant cells in tissue removed from human implant surgeries have been shown in situ to express macrophage-associated membrane molecules such as CD45 (leukocyte common antigen), CD13, CD14, CD15A (Hapten X), CD37, CD39, CD43, and HLA-DR; receptors such as CD16 (FcRIII), CD31 (FcRII), CD35 (C3b receptor), CD71 (transferrin receptor); and adhesion molecules such as CD11a,b,c, CD18 (leukoc”
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Metadata
- Authors
- Doussis, I. A., Puddle, B., & Athanasou, N. A.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 1992-05
- Volume
- 45
- Issue
- 5
- Pages
- 398-404
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- PMC
- PMC495300
- OpenAlex
- W1982665590
- Cited by
- 63
- References
- 27
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
- Health Sciences › Dentistry › Oral Surgery › Oral and Maxillofacial Pathology
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Keywords
- giant cell lesions, giant cell tumor of bone, giant cell reparative granuloma, osteoclasts, HLA-DR, CD68, CD45, immunophenotype, differential diagnosis, granuloma, bone lesions, soft tissue lesions
- MeSH terms
- Bone Diseases, Bone Neoplasms, HLA-DR Antigens, Humans, Immunoenzyme Techniques, Macrophages, Osteoclasts, Soft Tissue Neoplasms, Giant Cells, Immunophenotyping
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