The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index.
Immunophenotype of multinucleated and mononuclear cells in giant cell lesions of bone and soft tissue
Open accessAbstract
AIMS: To compare the antigenic phenotype of giant cells in giant cell lesions of bone and soft tissue with that of osteoclasts and macrophage polykaryons. METHODS: Formalin fixed, paraffin wax embedded sections of 106 giant cell lesions, 19 granulomatous, and 14 osteoclast containing lesions were immuno-histochemically stained for leucocyte common antigen (LCA), CD68, and HLA-DR. RESULTS: Osteoclasts and giant cells of giant cell tumour of bone and giant cell reparative granuloma could be distinguished by their generalised absence of HLA-DR reaction from macrophage polykaryons and giant cells in other giant cell lesions of bone and soft tissue. Staining for LCA, CD68, and HLA-DR was useful in distinguishing reactive histiocytic giant cells and osteoclasts from tumour giant cells. CONCLUSIONS: A panel of macrophage associated antigens should be diagnostically useful in differentiating the histological nature of giant cells in various giant cell lesions of bone and soft tissue.
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“Foreign body giant cells in tissue removed from human implant surgeries have been shown in situ to express macrophage-associated membrane molecules such as CD45 (leukocyte common antigen), CD13, CD14, CD15A (Hapten X), CD37, CD39, CD43, and HLA-DR; receptors such as CD16 (FcRIII), CD31 (FcRII), CD35 (C3b receptor), CD71 (transferrin receptor); and adhesion molecules such as CD11a,b,c, CD18 (leukoc”
From Foreign body reaction to biomaterials (2008) · cites this paper as [75]
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Cites
Tumors and Tumorlike Lesions of Bone and Joints
Schajowicz, F. (1981) · Springer eBooks · doi:10.1007/978-1-4684-0098-4 · Cited by 485
Pulford, K. A., Rigney, E. M., Micklem, K. J., Jones, M., Stross, W. P., Gatter, K. C., & Mason, D. Y. (1989) · Journal of Clinical Pathology · doi:10.1136/jcp.42.4.414 · Cited by 466
Monoclonal antibody to cytokeratin for use in routine histopathology.
Makin, C. A., Bobrow, L. G., & Bodmer, W. F. (1984) · Journal of Clinical Pathology · doi:10.1136/jcp.37.9.975 · Cited by 464
Diagnosis of Human Lymphoma with Monoclonal Antileukocyte Antibodies
Warnke, R. A., Gatter, K. C., Falini, B., Hildreth, P., Woolston, R.-E., Pulford, K., Cordell, J. L., Cohen, B., De Wolf-Peeters, C., & Mason, D. Y. (1983) · New England Journal of Medicine · doi:10.1056/nejm198311243092102 · Cited by 366
Winchester, R. J., & Kunkel, H. G. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60801-9 · Cited by 270
Giant cell tumor of the bone ; its pathological appearance, grading, supposed variant and treatment
Jaffe, H. L. (1940) · Cited by 219
Athanasou, N. A., & Quinn, J. (1990) · Journal of Clinical Pathology · doi:10.1136/jcp.43.12.997 · Cited by 182
Self-citationNon-osteogenic fibroma of bone.
Jaffe, H. L., & Lichtenstein, L. (1942) · Europe PMC (PubMed Central) · Cited by 161
Giant-Cell Tumors of Bone (Osteoclastoma): A Pathological and Histochemical Study
Schajowicz, F. (1961) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-196143010-00001 · Cited by 160
The effects of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells
Chambers, T. J., Fuller, K., McSheehy, P. M. J., & Pringle, J. A. S. (1985) · The Journal of Pathology · doi:10.1002/path.1711450403 · Cited by 148
Resorption of bone by inflammatory cells derived from the joint capsule of hip arthroplasties
Athanasou, N., Quinn, J. M. W., & Bulstrode, C. (1992) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.74b1.1732267 · Cited by 146
Self-citationFailure of cells of the mononuclear phagocyte series to resorb bone
Chambers, T. J., & Horton, M. A. (1984) · Calcified Tissue International · doi:10.1007/bf02405365 · Cited by 134
Carrasco, C. H., & Murray, J. A. (1989) · PubMed · Cited by 127
Ultrastructure of giant cell tumors of bone
Steiner, G. C., Ghosh, L., & Dorfman, H. D. (1972) · Human Pathology · doi:10.1016/s0046-8177(72)80007-8 · Cited by 102
Horton, M. A., Rimmer, E. F., Lewis, D., Pringle, J. A. S., Fuller, K., & Chambers, T. J. (1984) · The Journal of Pathology · doi:10.1002/path.1711440410 · Cited by 102
Mirra, J. M., Gold, R. H., & Rand, F. F. (1982) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198208000-00036 · Cited by 91
Epenetos, A. A., Bobrow, L. G., Adams, T. E., Collins, C. M. P., Isaacson, P. G., & Bodmer, W. F. (1985) · Journal of Clinical Pathology · doi:10.1136/jcp.38.1.12 · Cited by 86
Effect of decalcification agents on immunoreactivity of cellular antigens.
Athanasou, N. A., Quinn, J. M. W., Heryet, A. R., Woods, C. G., & McGee, J. O. (1987) · Journal of Clinical Pathology · doi:10.1136/jcp.40.8.874 · Cited by 82
Self-citationAthanasou, N. A., Bliss, E., Gatter, K. C., Heryet, A. R., Woods, C. G., & McGee, J. O. (1985) · The Journal of Pathology · doi:10.1002/path.1711470302 · Cited by 66
Self-citationBone resorption by macrophage polykaryons of giant cell tumour of tendon sheath
Athanasou, N., Quinn, J. M. W., Ferguson, D., & McGee, J. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.125 · Cited by 37
Self-citationBosch, A. L., Olaya, A. P., & Fernandez, A. L. (1974) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00433771 · Cited by 26
Use of monoclonal antibodies to recognise osteoclasts in routinely processed bone biopsy specimens.
Athanasou, N. A., Puddle, B., Quinn, J. M. W., & Woods, C. G. (1991) · Journal of Clinical Pathology · doi:10.1136/jcp.44.8.664 · Cited by 22
Self-citationHeterologous transplantation of human hematopoietic cell lines
Imamura, T., Huang, C. C., Minowada, J., & Moore, G. E. (1970) · Cancer · doi:10.1002/1097-0142(197006)25:6<1408::aid-cncr2820250622>3.0.co;2-# · Cited by 21
NON-OSTEOGENIC FIBROMA OF BONE
Devlin, J. A., Bowman, H. E., & Mitchell, C. L. (1955) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-195537030-00003 · Cited by 17
HLA‐DR antigen detection in giant cell lesions
Regezi, J. A., Zarbo, R. J., & Lloyd, R. V. (1986) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.1986.tb00653.x · Cited by 13
Roessner, A., Vollmer, E., Zwadlo, G., Sorg, C., Kolve, M., Bassewitz, D. B. V., Wuisman, P. I. J. M., Härle, A., & Grundmann, E. (1989) · Current topics in pathology · doi:10.1007/978-3-642-74462-4_9 · Cited by 11
Research works printed but not linked: 3
- Jaffe HL, Lichtenstein L, Portis RB. Giant cell tumor of bone. Its pathologic appearance, grading, supposed variants and treatment. Arch Pathol 1940;30:993-1031.
- Naiem M, Gerdes J, Abdulaziz Z, Nash J, Stein H, Mason DY. Production ofmonoclonal antibodies for the immunohistological analysis ofhuman lymphoma. In: Knapp W, et al, eds. Leukaemia markers. New York: Academic Press, 1981:117-25.
- Mirra JM. Fibrohistiocytic tumours of intramedullary origin. In: Mirra JM, ed. Bone tumors: clinical, radiologic andpathologic correlations. Philadelphia: Lea and Febiger, 1989:691-800.
Cited by
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138
Method for grading breast cancer.
Elston, E., & Ellis, I. O. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.2.189-b · Cited by 201
Localized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials
Higgins, D. M., Basaraba, R. J., Hohnbaum, A. C., Lee, E. J., Grainger, D. W., & Juarrero, M. G. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080962 · Cited by 188
Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivo
Ghanaati, S., Barbeck, M., Orth, C., Willershausen, I., Thimm, B. W., Hoffmann, C., Rasic, A., Sader, R. A., Unger, R. E., Peters, F., et al. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.006 · Cited by 178
Current Concepts Review - Cellular Biology of Bone-Resorbing Cells*
Athanasou, N. A. (1996) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199607000-00016 · Cited by 141
Self-citation
Metadata
- Authors
- Doussis, I. A., Puddle, B., & Athanasou, N. A.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 1992-05
- Volume
- 45
- Issue
- 5
- Pages
- 398-404
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- PMC
- PMC495300
- OpenAlex
- W1982665590
- Cited by
- 63
- References
- 27
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
- Health Sciences › Dentistry › Oral Surgery › Oral and Maxillofacial Pathology
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Keywords
- giant cell lesions, giant cell tumor of bone, giant cell reparative granuloma, osteoclasts, HLA-DR, CD68, CD45, immunophenotype, differential diagnosis, granuloma, bone lesions, soft tissue lesions
- MeSH terms
- Bone Diseases, Bone Neoplasms, HLA-DR Antigens, Humans, Immunoenzyme Techniques, Macrophages, Osteoclasts, Soft Tissue Neoplasms, Giant Cells, Immunophenotyping
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