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PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables.
Open accessAbstract
AIMS: To investigate the expression of two cell cycle related antigens (proliferating cell nuclear antigen (PCNA) and Ki67 related antigen) in a series of breast cancers; and the possible correlations between the PCNA and Ki67 labelling indexes (PCNA-LI and Ki67-LI) and their associations with other biological and clinicopathological variables. METHODS: Ninety six ductal and 10 lobular carcinoma specimens were investigated. Samples were fixed in formalin and in Methacarnoy for localisation of PCNA. Ki67 was immunostained on frozen sections. The PCNA-LI and Ki67-LI were evaluated in relation to tumour size, mitotic count, histological grade, nodal state as well as receptor content and altered expression of the p53 gene. RESULTS: PCNA-LI did not correlate with Ki67-LI, nor was it associated with any other variable examined. A high KI67-LI (above the median value of 13.5) was associated with high grade and mitotic count, negative receptor content, and altered expression of the p53 gene, but not with other variables. CONCLUSIONS: The PCNA-LI does not seem to be a substitute for the Ki67-LI in evaluating the growth fraction in breast cancer.
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Cited by
Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer
Juríková, M., Danihel, Ľ., Polák, Š., & Varga, I. (2016) · Acta Histochemica · doi:10.1016/j.acthis.2016.05.002 · Cited by 608
Mertens, C., Akam, E. A., Rehwald, C., Brüne, B., Tomat, E., & Jung, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166164 · Cited by 83
Soy consumption and histopathologic markers in breast tissue using tissue microarrays
Maskarinec, G., Erber, E., Verheus, M., Hernandez, B. Y., Killeen, J., Cashin, S., & Cline, J. M. (2009) · Nutrition and Cancer · doi:10.1080/01635580902913047 · Cited by 17
Metadata
- Authors
- Leonardi, E., Girlando, S., Serio, G., Mauri, F. A., Perrone, G., Scampini, S., Dalla Palma, P., & Barbareschi, M.
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 1992-05
- Volume
- 45
- Issue
- 5
- Pages
- 416-419
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W1984975924
- Cited by
- 241
- References
- 0
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Leonardi, E., Girlando, S., Serio, G., Mauri, F. A., Perrone, G., Scampini, S., Dalla Palma, P., & Barbareschi, M. (1992). PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables. Journal of Clinical Pathology. https://doi.org/10.1136/jcp.45.5.416
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