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Cited by 32Sepsis Diagnosis and TreatmentGastrointestinal motility and disordersAbdominal Surgery and Complications

Intra-abdominal sepsis: an immunocytochemical study of the small intestine mucosa

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Coutinho, H B, Robalinho, T I, Coutinho, V B, Amorim, A M, Furtado, A F, Ferraz, A, Ferraz, E, Walker, F +3 more·1997·Journal of Clinical Pathology
DOI 10.1136/jcp.50.4.294PMC PMC499878
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Abstract

AIM: To investigate immunocytochemical changes in intestinal tissues from patients with intra-abdominal sepsis, and to relate the changes to the possibility of enhanced bacterial adhesion and translocation. METHODS: Tissues from 17 patients suffering from intra-abdominal sepsis and from controls were sectioned and stained immunocytochemically for IgA, IgM, secretory component, J chain, and HLA-DR. Differences in the distribution and characteristics of positively staining cells between the patient groups were assessed. RESULTS: Patients with intra-abdominal sepsis had noticeable reductions in numbers of IgA and IgM plasma cells, reduced J chain staining, and had little immunoglobulin on the surfaces of enterocytes. In contrast, HLA-DR positive cells were increased in the sepsis compared with the control group. The plasma cells present showed cytological changes suggestive of apoptosis. CONCLUSIONS: Stress associated with sepsis and its immediate causes might result in increased plasma glucocorticoid levels that bring about apoptosis of mucosal plasma cells (or their precursors). The consequent reduction in expression of IgA and IgM may favour bacterial adhesion to the enterocytes and facilitate bacterial translocation into the tissues.

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  • In critical illness, bile salt production drops, IgA production is impaired, and the dense mucosal barrier of secreted antimicrobial peptides is lost.

    “bile salt production drops,17 IgA production is impaired,31 and the dense mucosal barrier of secreted antimicrobial peptides is lost.”

    From The microbiome and critical illness (2016) · cites this paper as [31]

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Research works printed but not linked: 3

  1. Marshall JC, Christou NV, HorJn R, Meakins JL. The microbiology of multiple organ failure. Arch Surg 1988; 123:309.
  2. Arends MJ, Wyllie AH. Apoptosis: mechanism and role in pathology. Int Rev Exp Pathol 1991;32:223-54.
  3. Cech AC, Shou J, Gallagher H, Daly JM. Glucocorticoid receptor blockage reserves postinjury macrophage suppres- sion. Arch Surg 1994;129:1227-32.

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Authors
Coutinho, H. B., Robalinho, T. I., Coutinho, V. B., Amorim, A. M., Furtado, A. F., Ferraz, A., Ferraz, E., Walker, F., King, G., Sewell, H. F., & Wakelin, D.
Affiliations
Instituto Aggeu Magalhães (BR)
Venue
Journal of Clinical Pathology
Publisher
BMJ
Published
1997-04
Volume
50
Issue
4
Pages
294-298
ISSN
  • 0021-9746 (ISSN-L)
  • 1472-4146
DOI
10.1136/jcp.50.4.294
PMC
PMC499878
OpenAlex
W2039760627
Cited by
32
References
29
Citations by year
2022: 1 · 2020: 1 · 2016: 1 · 2015: 2 · 2013: 3 · 2012: 1
FWCI
2.19
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Pathology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
European Commission
Topics
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Abdominal Surgery and Complications
Keywords
abdominal sepsis, small intestinal mucosa, IgA, IgM, J chain, HLA-DR, plasma cells, apoptosis, bacterial adhesion, bacterial translocation, glucocorticoids, enterocytes, immunocytochemistry
MeSH terms
Adult, Aged, Female, HLA-DR Antigens, Humans, Immunoglobulin A, Immunoglobulin M, Immunoglobulin J-Chains, Immunohistochemistry, Intestinal Diseases, Intestine, Small, Male, Middle Aged, Mucous Membrane, Secretory Component, Apoptosis, Sepsis

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