The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
APC mutation and tumour budding in colorectal cancer
Open accessAbstract
Aim: To determine the frequency of tumour budding and somatic APC mutation in a series of colorectal cancers stratified according to DNA microsatellite instability (MSI) status. Material/Methods: Ninety five colorectal cancers were genotyped for APC mutation in the mutation cluster region (exon 15) and scored for the presence of tumour budding at the invasive margin in haematoxylin and eosin stained sections. A subset was immunostained for β catenin and p16. Results: The frequency of both somatic APC mutation and tumour budding increased pari passu in cancers stratified as sporadic MSI high (MSI-H), hereditary non-polyposis colorectal cancer (HNPCC), MSI low (MSI-L), and microsatellite stable (MSS). Both budding and APC mutation were significantly less frequent in sporadic MSI-H cancers than in MSI-L or MSS cancers. Tumour buds were characterised by increased immunostaining for both β catenin and p16. Conclusion: Tumour budding is associated with an adverse prognosis. The lack of budding in MSI-H colorectal cancer may account for the improved prognosis of this subset and may be explained by an intact WNT signalling pathway and/or inactivated p16 INK4a .
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Cites
APC, Signal transduction and genetic instability in colorectal cancer
Fodde, R., Smits, R., & Clevers, H. (2001) · Nature Reviews Cancer · doi:10.1038/35094067 · Cited by 937
Jung, A., Schrauder, M., Oswald, U., Knoll, C., Sellberg, P., Palmqvist, R., Niedobitek, G., Brabletz, T., & Kirchner, T. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63007-6 · Cited by 217
Cited by
Zlobec, I., & Lugli, A. (2010) · Oncotarget · doi:10.18632/oncotarget.199 · Cited by 331
New Criteria for Histologic Grading of Colorectal Cancer
Ueno, H., Kajiwara, Y., Shimazaki, H., Shinto, E., Hashiguchi, Y., Nakanishi, K., Maekawa, K., Katsurada, Y., Nakamura, T., Mochizuki, H., et al. (2012) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318235edee · Cited by 227
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC
Schell, M. J., Yang, M., Teer, J. K., Lo, F. Y., Madan, A., Coppola, D., Monteiro, A. N. A., Nebozhyn, M. V., Yue, B., Loboda, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11743 · Cited by 207
Metadata
- Authors
- Jass, J. R., Barker, M., Fraser, L., Walsh, M. D., Whitehall, V. L. J., Gabrielli, B., Young, J., & Leggett, B. A.
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2003-01
- Volume
- 56
- Issue
- 1
- Pages
- 69-73
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W2154515128
- Cited by
- 160
- References
- 2
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jass, J. R., Barker, M., Fraser, L., Walsh, M. D., Whitehall, V. L. J., Gabrielli, B., Young, J., & Leggett, B. A. (2003). APC mutation and tumour budding in colorectal cancer. Journal of Clinical Pathology. https://doi.org/10.1136/jcp.56.1.69
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