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Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease: Table 1
Abstract
Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). Objective and methods: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case–control dataset. Results: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders.
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“5) Some regions reveal surprising associations. For example, unexpected connections have emerged among T2D, inflammatory diseases (two loci), and cancer (four loci). A single intron of CDKAL1 was found to contain a SNP associated with T2D and insulin secretion defects (99–101, 116), and another with Crohn’s disease and psoriasis (117).”
From Genetic Mapping in Human Disease (2008) · cites this paper as [117]
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Metadata
- Authors
- Wolf, N., Quaranta, M., Prescott, N. J., Allen, M., Smith, R., Burden, A. D., Worthington, J., Griffiths, C. E. M., Mathew, C. G., Barker, J. N., Capon, F., & Trembath, R. C.
- Affiliations
- King's College London (GB)
- University of Manchester (GB)
- Western Infirmary (GB)
- Guy's Hospital (GB)
- Corresponding author
- Trembath, R C
- ORCID
- Venue
- Journal of Medical Genetics
- Publisher
- BMJ
- Published
- 2007-11-09
- Volume
- 45
- Issue
- 2
- Pages
- 114-116
- ISSN
- 0022-2593 (ISSN-L)
- 1468-6244
- OpenAlex
- W2102254371
- Cited by
- 171
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 11 · 2013: 11 · 2012: 17
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Funders
- Wellcome Trust (068545/Z/02))
- Psoriasis Association (ST1/07)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Keywords
- psoriasis, Crohn's disease, type 2 diabetes, pleiotropy, genetic susceptibility loci, CDKAL1, IL12B, IL23R, major histocompatibility complex, chromosome 6p21, chromosome 21q22, immune-mediated inflammatory diseases, genetic overlap
- MeSH terms
- Adult, Alleles, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 6, Crohn Disease, Diabetes Mellitus, Type 2, Female, Gene Frequency, Humans, Male, Psoriasis, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Databases, Genetic
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