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Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease: Table 1
Abstract
Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the major histocompatibility complex (MHC) region on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn disease (CD). Objective and methods: To ascertain the genetic overlap between these two inflammatory conditions further, we investigated 15 CD-associated loci in a psoriasis case–control dataset. Results: The analysis of 1256 patients and 2938 unrelated controls found significant associations for loci mapping to chromosomes 1q24 (rs12035082, p = 0.009), 6p22 (rs6908425, p = 0.00015) and 21q22 (rs2836754, p = 0.0003). Notably, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type 2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for s genes that contribute to the pathogenesis of immune-mediated disorders.
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“5) Some regions reveal surprising associations. For example, unexpected connections have emerged among T2D, inflammatory diseases (two loci), and cancer (four loci). A single intron of CDKAL1 was found to contain a SNP associated with T2D and insulin secretion defects (99–101, 116), and another with Crohn’s disease and psoriasis (117).”
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Pathogenesis and clinical features of psoriasis
Griffiths, C. E. M., & Barker, J. N. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61128-3 · Cited by 2,215
Self-citationReplication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194
Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., & Sakaguchi, S. (2002) · Nature Immunology · doi:10.1038/ni759 · Cited by 1,729
Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,175
Self-citationCargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/511051 · Cited by 1,086
Capon, F., Meglio, P. D., Szaub, J., Prescott, N. J., Dunster, C., Southgate, L., Timms, K. M., Gutin, A., Abkevich, V., Burden, A. D., et al. (2007) · Human Genetics · doi:10.1007/s00439-007-0397-0 · Cited by 407
Self-citation
Research works printed but not linked: 1
- Zeggini, 2007, Replication of genome-wide association signals in u.k. samples reveals risk loci for type 2 diabetes., 316, 1336
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Sorted by citations
Nestle, F. O., Kaplan, D. H., & Barker, J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804595 · Cited by 2,867
Self-citationBoehncke, W., & Schön, M. P. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61909-7 · Cited by 2,609
Genetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452
Psoriasis and comorbid diseases
Takeshita, J., Grewal, S. K., Langan, S., Mehta, N. N., Ogdie, A., Voorhees, A. S. V., & Gelfand, J. M. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.07.064 · Cited by 1,228
Mehta, N. N., Azfar, R. S., Shin, D. B., Neimann, A. L., Troxel, A. B., & Gelfand, J. M. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp567 · Cited by 706
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Augustin, M., Glaeske, G., Radtke, M. A., Christophers, E., Reich, K., & Schäfer, I. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09593.x · Cited by 492
Perera, G. K., Meglio, P. D., & Nestle, F. O. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132448 · Cited by 480
Psoriasis and metabolic syndrome: A systematic review and meta-analysis of observational studies
Armstrong, A. W., Harskamp, C. T., & Armstrong, E. J. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.08.015 · Cited by 472
Signaling pathways and targeted therapies for psoriasis
Guo, J., Zhang, H., Lin, W., Lu, L., Su, J., & Chen, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01655-6 · Cited by 489
Co-morbidity and Age-related Prevalence of Psoriasis: Analysis of Health Insurance Data in Germany
Augustin, M., Reich, K., Glaeske, G., Schaefer, I., & Radtke, M. A. (2010) · Acta Dermato Venereologica · doi:10.2340/00015555-0770 · Cited by 334
PsoriasisPreprint
Meglio, P. D., Villanova, F., & Nestle, F. O. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015354 · Cited by 315
Reich, K., Gooderham, M., Thaçi, D., Crowley, J., Ryan, C., Krueger, J. G., Tsai, T., Flack, M., Gu, Y., Williams, D., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30952-3 · Cited by 301
Psoriasis and metabolic disease: epidemiology and pathophysiology
Azfar, R. S., & Gelfand, J. M. (2008) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283031c99 · Cited by 297
Psoriasis: is the impairment to a patient’s life cumulative?
Kimball, A. B., Gieler, U., Linder, D., Sampogna, F., Warren, R. B., & Augustin, M. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03705.x · Cited by 281
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Takeshita, J., Grewal, S. K., Langan, S., Mehta, N. N., Ogdie, A., Voorhees, A. S. V., & Gelfand, J. M. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.07.065 · Cited by 242
Immunopathogenesis of Psoriasis
Nickoloff, B. J., Qin, J., & Nestle, F. O. (2007) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-007-0039-2 · Cited by 218
Warren, R. B., Blauvelt, A., Poulin, Y. P., Beeck, S., Kelly, M., Wu, T., Geng, Z., & Paul, C. F. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19341 · Cited by 210
Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis
Wu, J. J., Kavanaugh, A., Lebwohl, M. G., Gniadecki, R., & Merola, J. F. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18044 · Cited by 225
Hu, S. C., & Lan, C.-C. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102211 · Cited by 199
Identification of ZNF313 / RNF114 as a novel psoriasis susceptibility gene
Capon, F., Bijlmakers, M.-J., Wolf, N., Quaranta, M., Hüffmeier, U., Allen, M., Timms, K. M., Abkevich, V., Gutin, A., Smith, R., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn091 · Cited by 198
Self-citationEtiology and Pathogenesis of Psoriasis
Boehncke, W.-H. (2015) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2015.07.013 · Cited by 197
New Insights in the Immunologic Basis of Psoriasis
Nograles, K. E., Davidovici, B. B., & Krueger, J. G. (2010) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2010.03.001 · Cited by 200
Psoriasis, psoriatic arthritis and increased risk of incident Crohn's disease in US women
Li, W., Han, J., Chan, A. T., & Qureshi, A. A. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202143 · Cited by 195
Schreiber, S., Colombel, J., Feagan, B. G., Reich, K., Deodhar, A. A., McInnes, I. B., Porter, B. O., Gupta, A. D., Pricop, L., & Fox, T. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-214273 · Cited by 194
Psoriasis associated with ulcerative colitis and Crohn's disease
Cohen, A., Dreiher, J., & Birkenfeld, S. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.03031.x · Cited by 194
Psoriasis and comorbidities: links and risks
Chiu, M. W., & Ni, C. S. (2014) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s44843 · Cited by 156
Prey, S., Paul, C. F., Bronsard, V., Puzenat, E., Gourraud, P., Aractingi, S., Aubin, F., Bagot, M., Cribier, B. J., Joly, P., et al. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2009.03564.x · Cited by 144
Managing comorbid disease in patients with psoriasis
Boehncke, W., Boehncke, S., & Schön, M. P. (2010) · BMJ · doi:10.1136/bmj.b5666 · Cited by 139
Cardiovascular Disease and Risk Factors in Patients with Psoriasis and Psoriatic Arthritis
Tobin, A., Veale, D. J., FitzGerald, O., Rogers, S., Collins, P. M., O'Shea, D. B., & Kirby, B. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.090822 · Cited by 134
More than skin deep: atherosclerosis as a systemic manifestation of psoriasis
ALEXANDROFF, A. B., Pauriah, M., Camp, R. D. R., Lang, C. C., Struthers, A. D., & Armstrong, D. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09281.x · Cited by 131
Dermatological Manifestations in Inflammatory Bowel Diseases
Antonelli, E., Bassotti, G., Tramontana, M., Hansel, K., Stingeni, L., Ardizzone, S., Genovese, G., Marzano, A. V., & Maconi, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020364 · Cited by 127
Hüffmeier, U., Lascorz, J., Böhm, B. B., Lohmann, J., Wendler, J., Mößner, R., Reich, K., Traupe, H., Kurrat, W., Burkhardt, H., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.233 · Cited by 122
Correlations between Psoriasis and Inflammatory Bowel Diseases
Skroza, N., Proietti, I., Pampena, R., Viola, G. L., Bernardini, N., Nicolucci, F., Tolino, E., Zuber, S., Soccodato, V., & Potenza, C. (2013) · BioMed Research International · doi:10.1155/2013/983902 · Cited by 114
Chiricozzi, A., Raimondo, A., Lembo, S., Fausti, F., Dini, V., Costanzo, A., Monfrecola, G., Balato, N., Ayala, F., Romanelli, M., et al. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1201423 · Cited by 98
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Gyldenløve, M., Storgaard, H., Holst, J. J., Vilsbøll, T., Knop, F. K., & Skov, L. (2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.01.004 · Cited by 103
Psoriasis and Atopic Dermatitis
Griffiths, C. E. M., van de Kerkhof, P., & Czarnecka-Operacz, M. M. (2017) · Dermatology and Therapy · doi:10.1007/s13555-016-0167-9 · Cited by 88
Self-citationPrevalence and extent of subclinical atherosclerosis in patients with psoriasis
Yiu, K., Yeung, C. K., Zhao, C., Chan, J., Siu, C., Tam, S., Wong, C. ‐., Yan, G. H., Yue, W., Khong, P. L., et al. (2012) · Journal of Internal Medicine · doi:10.1111/joim.12002 · Cited by 85
Further Genetic Evidence for Three Psoriasis-Risk Genes: ADAM33, CDKAL1, and PTPN22
Li, Y., Liao, W. J., Chang, M., Schrodi, S. J., Bui, N., Catanese, J. J., Poon, A., Matsunami, N., Callis-Duffin, K. P., Leppert, M., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.297 · Cited by 80
Li, Y., & Begovich, A. B. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.04.002 · Cited by 81
Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper
Girolomoni, G., Griffiths, C. E. M., Krueger, J. G., Nestle, F. O., Nicolas, J., Prinz, J. C., Puig, L., Ståhle, M., van de Kerkhof, P. C. M., Allez, M., et al. (2014) · Journal of Dermatological Treatment · doi:10.3109/09546634.2014.880396 · Cited by 73
Self-citationCarriers of Rare Missense Variants in IFIH1 Are Protected from Psoriasis
Li, Y., Liao, W. J., Cargill, M., Chang, M., Matsunami, N., Feng, B., Poon, A., Callis-Duffin, K. P., Catanese, J. J., Bowcock, A. M., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.214 · Cited by 72
Psoriasis and inflammatory bowel disease: links and risks
Bassukas, I. D., Gaitanis, G., Katsanos, K., Christodoulou, D. K., Tsianos, E. V., & Vlachos, C. (2016) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s85194 · Cited by 72
Association of Serum Uric Acid Levels in Psoriasis
Li, X., Miao, X., Wang, H., Wang, Y., Li, F., Yang, Q., Cui, R., & Li, B. (2016) · Medicine · doi:10.1097/md.0000000000003676 · Cited by 70
Psoriasis and Cardiometabolic Diseases: Shared Genetic and Molecular Pathways
Piaserico, S., Orlando, G., & Messina, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169063 · Cited by 71
Metabolic comorbidities and psoriasis.
Gisondi, P., Ferrazzi, A., & Girolomoni, G. (2010) · PubMed · Cited by 65
Haque, N., Lories, R. J. U., & de Vlam, K. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.141359 · Cited by 65
Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes
Quaranta, M., Burden, A. D., Griffiths, C. E. M., Worthington, J., Barker, J. N., Trembath, R. C., & Capon, F. (2009) · Genes and Immunity · doi:10.1038/gene.2009.51 · Cited by 65
Self-citationAssociation between Psoriasis and Cardiovascular Risk Factors in Korean Patients
Choi, W. J., Park, E. J., Kwon, I. H., Kim, K. H., & Kim, K. J. (2010) · Annals of Dermatology · doi:10.5021/ad.2010.22.3.300 · Cited by 62
Abordaje integral de la comorbilidad del paciente con psoriasis
Daudén, E., Castañeda, S., Suárez, C., García‐Campayo, J., Blasco, A. J., Aguilar, M. D., Ferrándiz, C., Puig, L., & Sánchez‐Carazo, J. L. (2012) · Actas Dermo-Sifiliográficas · doi:10.1016/s0001-7310(12)70001-7 · Cited by 58
Genetics of inflammatory bowel disease: clues to pathogenesis
Zhang, H., Massey, D. C. O., Tremelling, M., & Parkes, M. (2008) · British Medical Bulletin · doi:10.1093/bmb/ldn031 · Cited by 56
Menter, A., Griffiths, C. E. M., Tebbey, P. W., Horn, E., & Sterry, W. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03656.x · Cited by 57
Self-citationDigestive system in psoriasis: an update
Pietrzak, D., Pietrzak, A., Krasowska, D., Borzęcki, A., Franciszkiewicz-Pietrzak, K., Polkowska-Pruszyńska, B., Baranowska, M., & Reich, K. (2017) · Archives of Dermatological Research · doi:10.1007/s00403-017-1775-7 · Cited by 56
Srivastava, A., Yadav, T. C., Khera, H. K., Mishra, P., Raghuwanshi, N., Pruthi, V., & Prasad, R. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102614 · Cited by 53
Ciccacci, C., Biancone, L., Fusco, D. D., Ranieri, M., Condino, G., Giardina, E., Onali, S., Lepre, T., Pallone, F., Novelli, G., et al. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2012.02.020 · Cited by 53
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Rivière, J., Xiong, L., Levchenko, А., St‐Onge, J., Gaspar, C., Dion, Y., Lespérance, P., Tellier, G., Richer, F., Chouinard, S., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.213 · Cited by 54
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Harper, S. Q. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.180 · Cited by 54
Lee, M., Lin, R., & Lai, M. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.11.023 · Cited by 51
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Billi, A. C., Gudjonsson, J. E., & Voorhees, J. J. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.08.437 · Cited by 46
Topical delivery for the treatment of psoriasis
Mitra, A., & Wu, Y. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.503953 · Cited by 46
Rafiq, S., Melzer, D. R., Weedon, M. N., Lango, H., Saxena, R., Scott, L. J., Palmer, C. N. A., Morris, A. D., McCarthy, M. I., Ferrucci, L., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1160-3 · Cited by 47
Psoriasis increased the risk of diabetes: a meta-analysis
Cheng, J., Kuai, D., Zhang, L., Yang, X., & Qiu, B. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1200-6 · Cited by 46
The Pathogenesis and Genetics of Psoriasis
Puig, L., Julià, A., & Marsal, S. (2014) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2014.05.013 · Cited by 45
Psoriasis, the liver, and the gastrointestinal tract
Gisondi, P., Giglio, M. D., Cozzi, A., & Girolomoni, G. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2010.01310.x · Cited by 45
Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis
Zhu, K., Zhu, C., Shi, G., & Fan, Y. (2012) · Inflammation Research · doi:10.1007/s00011-012-0509-8 · Cited by 44
Integrated Approach to Comorbidity in Patients With Psoriasis
Daudén, E., Castañeda, S., Suárez, C., García‐Campayo, J., Blasco, A. J., Aguilar, M. D., Ferrándiz, C., Puig, L., & Sánchez‐Carazo, J. L. (2012) · Actas Dermo-Sifiliográficas · doi:10.1016/s1578-2190(12)70829-6 · Cited by 44
Robinson, P. C., Leo, P. J., Pointon, J. J., Harris, J., Cremin, K., Bradbury, L. A., Stebbings, S. M., Harrison, A. A., McCloskey, E. V., Eisman, J. A., et al. (2016) · npj Genomic Medicine · doi:10.1038/npjgenmed.2016.8 · Cited by 44
Self-citationPsoriasis: bases genéticas y patogenéticas
Puig, L., Julià, A., & Marsal, S. (2013) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2012.11.006 · Cited by 43
Bangsgaard, N., Engkilde, K., Thyssen, J. P., Linneberg, A. R., Nielsen, N. H., Menné, T., Skov, L., & Johansen, J. D. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09314.x · Cited by 43
Comorbidities in Patients with Psoriatic Arthritis
Haddad, A., & Zisman, D. (2017) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10279 · Cited by 42
Martyn-Simmons, C. L., Ranawaka, R. R., Chowienczyk, P., Crook, M. A., Marber, M. S., Smith, C. H., & Barker, J. N. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10031.x · Cited by 41
Self-citationCai, J., Cui, L., Wang, Y., Li, Y., Zhang, X., & Shi, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.774808 · Cited by 40
Duffin, K. C., Woodcock, J. L., & Krueger, G. G. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2010.01303.x · Cited by 39
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Gerdes, S., Mrowietz, U., & Boehncke, W. (2016) · Der Hautarzt · doi:10.1007/s00105-016-3805-3 · Cited by 38
Furue, M., & Kadono, T. (2016) · The Journal of Dermatology · doi:10.1111/1346-8138.13186 · Cited by 38
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Brambillasca, S., Altkrüger, A., Colombo, S. F., Friederich, A., Eickelmann, P., Mark, M., Borgese, N., & Solimena, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.376558 · Cited by 38
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Lima, E. D. A., & Lima, M. D. A. (2011) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962011000600014 · Cited by 35
Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients
Peluso, R., Caso, F., Tasso, M., Ambrosino, P., Nicola, M., Minno, M. N. D. D., Lupoli, R., Criscuolo, L., Caso, P., Ursini, F., et al. (2018) · Reviews on Recent Clinical Trials · doi:10.2174/1574887113666180314105511 · Cited by 35
The 5q31 variants associated with psoriasis and Crohn's disease are distinct
Li, Y., Chang, M., Schrodi, S. J., Callis-Duffin, K. P., Matsunami, N., Civello, D., Bui, N., Catanese, J. J., Leppert, M., Krueger, G. G., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn196 · Cited by 33
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Self-citationGyldenløve, M., Vilsbøll, T., Zachariae, C. O. C., Holst, J. J., Knop, F. K., & Skov, L. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12388 · Cited by 27
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Metadata
- Authors
- Wolf, N., Quaranta, M., Prescott, N. J., Allen, M., Smith, R., Burden, A. D., Worthington, J., Griffiths, C. E. M., Mathew, C. G., Barker, J. N., Capon, F., & Trembath, R. C.
- Affiliations
- King's College London (GB)
- University of Manchester (GB)
- Western Infirmary (GB)
- Guy's Hospital (GB)
- Corresponding author
- Trembath, R C
- ORCID
- Venue
- Journal of Medical Genetics
- Publisher
- BMJ
- Published
- 2007-11-09
- Volume
- 45
- Issue
- 2
- Pages
- 114-116
- ISSN
- 0022-2593 (ISSN-L)
- 1468-6244
- OpenAlex
- W2102254371
- Cited by
- 171
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 11 · 2013: 11 · 2012: 17
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Funders
- Wellcome Trust (068545/Z/02))
- Psoriasis Association (ST1/07)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Keywords
- psoriasis, Crohn's disease, type 2 diabetes, pleiotropy, genetic susceptibility loci, CDKAL1, IL12B, IL23R, major histocompatibility complex, chromosome 6p21, chromosome 21q22, immune-mediated inflammatory diseases, genetic overlap
- MeSH terms
- Adult, Alleles, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 6, Crohn Disease, Diabetes Mellitus, Type 2, Female, Gene Frequency, Humans, Male, Psoriasis, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Databases, Genetic
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