The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
Open accessAbstract
OBJECTIVE: To investigate the heterogeneity of idiopathic Parkinson's disease (PD) in a data driven manner among a cohort of patients in the early clinical stages of the disease meeting established diagnostic criteria. METHODS: Data on demographic, motor, mood, and cognitive measures were collected from 120 consecutive patients in the early stages of PD (Hoehn and Yahr I-III) attending a specialist PD research clinic. Statistical cluster analysis of the data allowed the existence of the patient subgroups generated to be explored. RESULTS: The analysis revealed four main subgroups: (a) patients with a younger disease onset; (b) a tremor dominant subgroup of patients; (c) a non-tremor dominant subgroup with significant levels of cognitive impairment and mild depression; and (d) a subgroup with rapid disease progression but no cognitive impairment. CONCLUSIONS: This study complements and extends previous research by using a data driven approach to define the clinical heterogeneity of early PD. The approach adopted in this study for the identification of subgroups of patients within Parkinson's disease has important implications for generating testable hypotheses on defining the heterogeneity of this common condition and its aetiopathological basis and thus its treatment.
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Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
JENKINSON, C., FITZPATRICK, R., PETO, V., GREENHALL, R., & HYMAN, N. (1997) · Age and Ageing · doi:10.1093/ageing/26.5.353 · Cited by 1,321
Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
Gill, S. S., Patel, N. K., Hotton, G. R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D. J., Svendsen, C. N., & Heywood, P. (2003) · Nature Medicine · doi:10.1038/nm850 · Cited by 1,290
SAHAKIAN, B. J., MORRIS, R. G., EVENDEN, J. L., HEALD, A., LEVY, R., PHILPOT, M., & ROBBINS, T. W. (1988) · Brain · doi:10.1093/brain/111.3.695 · Cited by 666
Self-citationDopamine-dependent frontostriatal planning deficits in early Parkinson's disease.
Owen, A. M., Sahakian, B. J., Hodges, J. R., Summers, B. A., Polkey, C. E., & Robbins, T. W. (1995) · Neuropsychology · doi:10.1037//0894-4105.9.1.126 · Cited by 294
Self-citationParkinson's disease with depression: A possible subgroup of idiopathic parkinsonism
Santamaria, J., Tolosa, E., & Valles, A. (1986) · Neurology · doi:10.1212/wnl.36.8.1130 · Cited by 233
Parker, F., Tzourio, N., Blond, S., Petit, H., & Mazoyer, B. (1992) · Brain Research · doi:10.1016/0006-8993(92)90872-7 · Cited by 81
Cited by
Clinical diagnostic criteria for dementia associated with Parkinson’s disease
Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027
Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges
Williams, D. R., & Lees, A. J. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70042-0 · Cited by 650
Fereshtehnejad, S.-M., Romenets, S. R., Anang, J. B. M., Latreille, V., Gagnon, J.-F., & Postuma, R. B. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0703 · Cited by 615
Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?
Helmich, R. C., Hallett, M., Deuschl, G., Toni, I., & Bloem, B. R. (2012) · Brain · doi:10.1093/brain/aws023 · Cited by 581
Cognitive Impairment in Parkinson’s Disease: The Dual Syndrome Hypothesis
Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2013) · Neurodegenerative Diseases · doi:10.1159/000341998 · Cited by 573
Metadata
- Authors
- Lewis, S. J. G.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2005-03-01
- Volume
- 76
- Issue
- 3
- Pages
- 343-348
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2110662841
- Cited by
- 551
- References
- 10
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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