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Cited by 666Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsCognitive Functions and Memory

A COMPARATIVE STUDY OF VISUOSPATIAL MEMORY AND LEARNING IN ALZHEIMER-TYPE DEMENTIA AND PARKINSON'S DISEASE

SAHAKIAN, BARBARA J., MORRIS, ROBIN G., EVENDEN, JOHN L., HEALD, ANDREW, LEVY, RAYMOND, PHILPOT, MICHAEL, ROBBINS, TREVOR W.·1988·Brain
DOI 10.1093/brain/111.3.695
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Abstract

Groups of patients with dementia of Alzheimer type (DAT) and idiopathic Parkinson's disease, together with age and IQ-matched normal controls, were compared on several computerized tests of visuospatial memory and learning. Two different groups of parkinsonian patients were studied: (1) a newly diagnosed group, early in the course of the disease, not receiving medication (NMED) PD) and (2) a group later in the course of the disease, receiving medication (MED PD). The DAT and MED PD group were significantly impaired in both spatial and visual pattern recognition memory. The DAT group exhibited a delay-dependent deficit (over 0-16 s) in a delayed matching-to-sample procedure, but were not impaired at simultaneous-matching-to-sample. By contrast, the MED PD group showed delay-independent deficits in the delayed matching-to-sample test and both the MED PD and the NMED PD group were also significantly impaired in simultaneous matching. In a form of delayed response test, the subjects were required first to memorize and then to learn the locations of several abstract visual stimuli which varied progressively in number from 1 to 8. The DAT group were severely impaired in this conditional associative learning task. A significant proportion of patients, but none of the controls, in the NMED and MED PD group also failed the test at the levels of 6 or 8 items. There was a significant correlation between the performance on the first trial, memory score in the delayed response task and in…

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  • The Cambridge spatial working memory test (CSWM) is an interactive game that evaluates visuospatial working memory.

    “This is an interactive game that evaluates visuospatial working memory (Sahakian et al., 1988).”

    From Does Spatial Cognition Emerge in Frontier Models? (2024) · cites this paper as Sahakian et al., 1988

  • The Cambridge Spatial Working Memory test (CSWM) was designed to evaluate spatial working memory in human subjects.

    “Cambridge spatial working memory test (CSWM). This was designed to evaluate spatial working memory in human subjects (Sahakian et al., 1988).”

    From Does Spatial Cognition Emerge in Frontier Models? (2024) · cites this paper as Sahakian et al., 1988

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Authors
SAHAKIAN, B. J., MORRIS, R. G., EVENDEN, J. L., HEALD, A., LEVY, R., PHILPOT, M., & ROBBINS, T. W.
Affiliations
  • University of Cambridge (GB)
  • Addenbrooke's Hospital (GB)
Corresponding author
MORRIS, ROBIN G.
ORCID
Venue
Brain
Publisher
Oxford University Press (OUP)
Published
1988
Volume
111
Issue
3
Pages
695-718
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
DOI
10.1093/brain/111.3.695
OpenAlex
W2168956721
Cited by
666
References
0
Citations by year
2026: 8 · 2025: 13 · 2024: 7 · 2023: 17 · 2022: 8 · 2021: 15 · 2020: 17 · 2019: 37 · 2018: 21 · 2017: 20 · 2016: 33 · 2015: 21 · 2014: 30 · 2013: 22 · 2012: 22
FWCI
14.22
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • Wellcome Trust
  • Nuffield Foundation
  • Newcastle University
  • Merck Sharp and Dohme
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
visuospatial memory, learning, Alzheimer's disease, Parkinson's disease, spatial pattern recognition, visual pattern recognition, delayed matching-to-sample, delayed response task, medication effects, disease duration, clinical disability, cognitive impairment
MeSH terms
Alzheimer Disease, Association Learning, Female, Humans, Learning, Male, Memory, Parkinson Disease, Pattern Recognition, Visual, Reaction Time, Space Perception, Visual Perception

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