The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial
Open accessAbstract
BACKGROUND: Excessive daytime somnolence (EDS) commonly complicates Parkinson's disease (PD). The aetiology of EDS is probably multifactorial but is probably exacerbated by dopaminergic medications. Modafinil is a wake-promoting agent approved for use in narcolepsy, but it is often used to treat a variety of somnolent conditions. METHOD: A double blind, placebo controlled parallel design trial was conducted to assess the efficacy of modafinil (200-400 mg/day) for the treatment of EDS in PD. The primary efficacy measure was the Epworth Sleepiness (ES) scale score. Secondary efficacy points included the Unified Parkinson's Disease Rating Scale (UPDRS), the Fatigue Severity Scale, the Hamilton Depression Scale, and the multiple sleep latency test (MSLT). RESULTS: Of a total of 40 subjects (29 men, mean (SD) age 64.8 (11.3) years), randomised to modafinil or placebo, 37 completed the study. Modafinil failed to significantly improve ES scores compared with placebo (2.7 v 1.5 points improvement, respectively, p = 0.28). MSLT failed to improve with modafinil relative to placebo (-0.16 v -0.70, respectively, p = 0.14). UPDRS, global impressions, Fatigue Severity Scale, and Hamilton Depression Scale scores were unchanged. Adverse events were minimal. CONCLUSION: Modafinil failed to significantly improve EDS in PD compared with placebo. The drug did not alter motor symptoms in PD and was well tolerated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364
Development of a Rating Scale for Primary Depressive Illness
HAMILTON, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410
The International Classification of Sleep Disorders: Diagnostic and Coding Manual
Daroff, R. B. (1991) · Neurology · doi:10.1212/wnl.41.1.160 · Cited by 5,014
Diagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822
Krupp, L. B., Alvarez, L. A., LaRocca, N. G., & Scheinberg, L. C. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520280085020 · Cited by 997
Unified Parkinson's disease rating scale characteristics and structure
Martínez‐Martín, P., Gil‐Nagel, A., Gracia, L. M., Gómez, J. B., Martínez‐Sarriés, J., Bermejo, F., & The Cooperative Multicentric Group (1994) · Movement Disorders · doi:10.1002/mds.870090112 · Cited by 796
Hobson, D. E., Lang, A. E., Martin, W. R. W., Razmy, A., Rivest, J., & Fleming, J. (2002) · JAMA · doi:10.1001/jama.287.4.455 · Cited by 553
Mitler, M. M., Gujavarty, K. S., & Browman, C. P. (1982) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(82)90142-0 · Cited by 522
Parkinson’s disease and sleepiness: An integral part of PD
Arnulf, I., Konofal, E., Merino–Andreu, M., Houeto, J. L., Mesnage, V., Welter, M. L., Lacomblez, L., Golmard, J. L., Derenne, J. P., & Agid, Y. (2002) · Neurology · doi:10.1212/wnl.58.7.1019 · Cited by 515
Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness
Scammell, T. E., Estabrooke, I. V., McCarthy, M. T., Chemelli, R. M., Yanagisawa, M., Miller, M. S., & Saper, C. B. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08620.2000 · Cited by 485
Cited by
Seppi, K., Weintraub, D., Coelho, M., Perez‐Lloret, S., Fox, S. H., Katzenschlager, R., Hametner, E., Poewe, W., Rascol, O., Goetz, C. G., et al. (2011) · Movement Disorders · doi:10.1002/mds.23884 · Cited by 1,141
The scientific and clinical basis for the treatment of Parkinson disease (2009)
Olanow, C. W., Stern, M. B., & Sethi, K. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a1d44c · Cited by 908
Practice Parameters for the Treatment of Narcolepsy and other Hypersomnias of Central Origin
Morgenthaler, T. I., Kapur, V. K., Brown, T. M., Swick, T. J., Alessi, C., Aurora, R. N., Boehlecke, B., Chesson, A. L., Friedman, L., Maganti, R., et al. (2007) · Sleep · doi:10.1093/sleep/30.12.1705 · Cited by 488
Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons
Bloom, H. G., Ahmed, I., Alessi, C. A., Ancoli‐Israel, S., Buysse, D. J., Kryger, M. H., Phillips, B. A., Thorpy, M. J., Vitiello, M. V., & Zee, P. C. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02220.x · Cited by 464
A Systematic Review of Modafinil: Potential Clinical Uses and Mechanisms of Action
Ballon, J. S., & Feifel, D. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0406 · Cited by 349
Metadata
- Authors
- Ondo, W. G.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2005-12-01
- Volume
- 76
- Issue
- 12
- Pages
- 1636-1639
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2023846401
- Cited by
- 268
- References
- 34
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial. https://app.cochat.ai/papers/10.1136/jnnp.2005.065870
- The paper
- Ondo, W. G. (2005). Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.2005.065870
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
