Treatment of epilepsy with clonazepam and its effect on other anticonvulsants
Open accessAbstract
Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial. Considerable improvement occurred with patients with myoclonic jerks and tonic-clonic convulsions, and with photosensitive epilepsy. Patients with atypical petit mal and focal epilepsies also improved. Drowsiness was initially common but lasted only a short time. No evidence was found for an action of clonazepam on the metabolism of other drugs, but treatment with phenobarbitone lowered serum concentrations of clonazepam. We conclude that clonazepam is particularly valuable in epilepsy with associated myoclonsu and in photosensitive epilepsy.
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Clonazepam has been shown to be effective as adjunctive therapy for complex partial, absence, tonic-clonic, and myoclonic seizures.
“Clonazepam has been shown to be effective as adjunctive therapy for complex partial seizures, absence seizures, tonic-clonic seizures and myoclonic seizures (121, 122).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [121]
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Benzodiazepines in the Treatment of Epilepsy A Review
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Serum clonazepam concentrations in children with absence seizures
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Goudie, J. H., & Burnett, D. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90482-8 · Cited by 58 · see citing works
CLONAZEPAM IN THE TREATMENT OF EPILEPSY
Huang, C. Y., McLeod, J. G., Sampson, D. C., et al. (1974) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1974.tb93563.x · Cited by 53 · see citing works
ASSAY AND PHARMACOKINETICS OF CLONAZEPAM IN HUMANS
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Research works printed but not linked: 3
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Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics
Riss, J., Cloyd, J., Gates, J., & Collins, S. (2008) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01004.x · Cited by 511 · see citing works
- Authors
- Nanda, R. N., Johnson, R. H., Keogh, H. J., Lambie, D. G., & Melville, I. D.
- Affiliations
- Wellington Hospital (NZ)
- ORCID
- Johnson, R H
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1977-06-01
- Volume
- 40
- Issue
- 6
- Pages
- 538-543
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC492759
- OpenAlex
- W2131995613
- Cited by
- 60
- References
- 11
- Citations by year
- 2022: 5 · 2020: 2 · 2018: 2 · 2016: 6 · 2015: 1 · 2012: 4
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- clonazepam, epilepsy, myoclonic jerks, photosensitive epilepsy, tonic-clonic seizures, focal epilepsy, drug interactions, phenobarbital, drug metabolism, sleepiness
- MeSH terms
- Adolescent, Adult, Ambulatory Care, Benzodiazepinones, Brain, Child, Clinical Trials as Topic, Clonazepam, Double-Blind Method, Drug Evaluation, Drug Interactions, Epilepsy, Epilepsies, Partial, Epilepsies, Myoclonic, Epilepsy, Absence, Epilepsy, Temporal Lobe, Female, Hospitalization, Humans, Male, Phenobarbital, Photic Stimulation
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