A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients
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The clinical anticonvulsant efficacy of single dose rectal and oral administration of diazepam 20 mg was examined in two double-blind placebo-controlled trials in adult epileptic patients. All subjects suffered from drug resistant epilepsy and frequently experienced serial seizures. Diazepam was administered rectally as a new experimental suppository formulation immediately after a seizure and was highly effective in preventing recurrent fits within a 24 h observation period (p less than 0.001). Pharmacokinetic studies revealed a wide range of serum diazepam concentrations 60 min after administration of the suppository (mean serum diazepam level 190 +/- 73 (SD ng/ml). In a similar study oral administration of diazepam 20 mg significantly reduced the incidence of serial seizures compared with a placebo (p less than 0.01) and the mean 60 min serum diazepam level was 273 +/- 190 (SD) ng/ml.
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Higher doses of rectal diazepam (20-30 mg) have been used in adults with drug-resistant epilepsy who are prone to serial seizures.
“and higher doses of rectal diazepam (20-30 mg) have been used in adult patients with drug-resistant epilepsy who are prone to serial seizures (94,95).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [94]
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- Authors
- Milligan, N. M., Dhillon, S., Griffiths, A., Oxley, J., & Richens, A.
- Affiliations
- University Hospital of Wales (GB)
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1984-03-01
- Volume
- 47
- Issue
- 3
- Pages
- 235-240
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1027720
- OpenAlex
- W2144565497
- Cited by
- 41
- References
- 15
- Citations by year
- 2022: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- diazepam, rectal administration, suppository formulation, oral administration, drug-resistant epilepsy, seizure prevention, anticonvulsant efficacy, pharmacokinetics
- MeSH terms
- Administration, Oral, Adolescent, Adult, Biological Availability, Clinical Trials as Topic, Diazepam, Epilepsy, Humans, Middle Aged, Suppositories
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