The DOI matches its Crossref record.
Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography.
Open accessAbstract
L-[18F] fluorodopa was administered in trace amounts intravenously to healthy control subjects and to patients with Parkinson's disease. Striatal uptake of radioactivity was measured using positron emission tomography. The capacity of the striatum to retain tracer was severely impaired in patients compared to controls. This may reflect a reduction of striatal dopamine storage in Parkinson's disease. Patients showing the "on/off" phenomenon had an even greater decrease of striatal storage capacity.
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Citations
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Metadata
- Authors
- Leenders, K. L., Palmer, A. J., Quinn, N., Clark, J. C., Firnau, G., Garnett, E. S., Nahmias, C., Jones, T., & Marsden, C. D.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1986-08-01
- Volume
- 49
- Issue
- 8
- Pages
- 853-860
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2043037767
- Cited by
- 354
- References
- 0
- FWCI
- 17.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Leenders, K. L., Palmer, A. J., Quinn, N., Clark, J. C., Firnau, G., Garnett, E. S., Nahmias, C., Jones, T., & Marsden, C. D. (1986). Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.49.8.853
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
