The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.
Open accessAbstract
A method for the volumetric assessment of early cerebral infarction, together with its statistical and biological validation, is described. In halothane anaesthetised rats the stem of the right middle cerebral artery was occluded and 3 hours later (with full monitoring of respiratory and cardiovascular status) the animals were killed by perfusion fixation. In normotensive normocapnic animals the volume of infarction was 52 +/- 4 mm3 in the cerebral cortex and 21 +/- 1 mm3 in the corpus striatum. The reproducibility of the volumetric assessment was found to be excellent (coefficient of correlation 0.995 on 18 replicate measurements). The minimum number of stereotactic levels which must be assessed to yield accurate volumetric measurements of infarction is 8. The method is sensitive at detecting alterations in the amount of infarction. For example, it can readily detect the increase in amount of structural damage in cerebral cortex following a transient episode of hypotension. This approach allows an objective assessment of drug therapy and management strategies in the treatment of cerebral infarction.
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Citations
Cites
Development of a Strain of Spontaneously Hypertensive Rats
OKAMOTO, K., & AOKI, K. (1963) · Japanese Circulation Journal · doi:10.1253/jcj.27.282 · Cited by 2,545
Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature · doi:10.1038/nature13909 · Cited by 2,907
A Semiautomated Method for Measuring Brain Infarct Volume
Swanson, R. A., Morton, M. T., Tsao-Wu, G., Savalos, R. A., Davidson, C., & Sharp, F. R. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.47 · Cited by 1,644
Rodent models of cerebral ischemia.
Ginsberg, M. D., & Busto, R. (1989) · Stroke · doi:10.1161/01.str.20.12.1627 · Cited by 659
Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat
Memezawa, H., Minamisawa, H., Smith, M.-L., & Siesj�, B. K. (1992) · Experimental Brain Research · doi:10.1007/bf00229002 · Cited by 310
Metadata
- Authors
- Osborne, K. A., Shigeno, T., Balarsky, A. M., Ford, I., McCulloch, J., Teasdale, G. M., & Graham, D. I.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1987-04-01
- Volume
- 50
- Issue
- 4
- Pages
- 402-410
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2166487601
- Cited by
- 297
- References
- 1
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Osborne, K. A., Shigeno, T., Balarsky, A. M., Ford, I., McCulloch, J., Teasdale, G. M., & Graham, D. I. (1987). Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.50.4.402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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