The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease.
Open accessAbstract
Significant loss of neurons in the pedunculopontine nucleus pars compacta (PPNc), a putative cholinergic nucleus involved in modulating somatic motor activities, has been demonstrated in progressive supranuclear palsy (PSP) and Parkinson's disease but not in Alzheimer's disease. A morphometric study of this nucleus was performed in two cases of PSP and in a cohort of cases of Parkinson's disease, Alzheimer's disease, senile dementia of Alzheimer type (SDAT), and age-matched controls. In PSP a significant 60% neuronal loss in PPNc was associated with neurofibrillary tangles in 40 to 64% of the remaining neurons. In Parkinson's disease there was a significant decrease in cell numbers and density by 53 and 51%, respectively, with Lewy bodies involving 6 to 39% of all neurons. In Alzheimer's disease and SDAT, large neurons were reduced by 29 and 33.8%, respectively, with tangles in 9 to 38% of the remaining cells. The selective affection of this putative cholinergic nucleus in PSP and Parkinson's disease appears to be related to motor dysfunctions in these disorders.
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Cites
Handbook of Clinical Neurology
Jellinger, K. A. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02422.x · Cited by 755
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Young onset Parkinson's disease
Quinn, N., Critchley, P., & Marsden, C. D. (1987) · Movement Disorders · doi:10.1002/mds.870020201 · Cited by 443
The pedunculopontine nucleus in Parkinson's disease
Zweig, R. M., Jankel, W. R., Hedreen, J. C., Mayeux, R., & Price, D. L. (1989) · Annals of Neurology · doi:10.1002/ana.410260106 · Cited by 386
Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons
Yamamoto, T., & Hirano, A. (1985) · Annals of Neurology · doi:10.1002/ana.410170608 · Cited by 338
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Cytoarchitecture of the Human Brain Stem
Bandler, R. (1983) · Pathology · doi:10.1016/s0031-3025(16)37288-9 · Cited by 299
The concept of subcortical and cortical dementia: Another look
Whitehouse, P. J. (1986) · Annals of Neurology · doi:10.1002/ana.410190102 · Cited by 204
Loss of pedunculopontine neurons in progressive supranuclear palsy
Zweig, R. M., Whitehouse, P. J., Casanova, M. F., Walker, L. C., Januarykel, W. R., & Price, D. L. (1987) · Annals of Neurology · doi:10.1002/ana.410220107 · Cited by 180
Cited by
Braak, H., & Del Tredici, K. (2017) · Journal of Parkinson’s Disease · doi:10.3233/jpd-179001 · Cited by 372
Arendt, T., Schindler, C., Brückner, M. K., Eschrich, K., Bigl, V., Zedlick, D., & Marcova, L. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00516.1997 · Cited by 319
Forster, G. L., & Blaha, C. D. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00250.x · Cited by 271
Mesulam, M. ‐., Geula, C., Bothwell, M. A., & Hersh, L. B. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902830414 · Cited by 270
Josset, N., Roussel, M., Lemieux, M., Lafrance-Zoubga, D., Rastqar, A., & Bretzner, F. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.007 · Cited by 194
Metadata
- Authors
- Jellinger, K.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1988-04-01
- Volume
- 51
- Issue
- 4
- Pages
- 540-543
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2119030930
- Cited by
- 373
- References
- 20
- FWCI
- 6.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jellinger, K. (1988). The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.51.4.540
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
