The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons
Abstract
Diffuse serotonergic fibers are presumed to project to the talencephalon from the nucleus raphe dorsalis (NRD) of the mid brain, in a manner similiar to the cholinergic projections from the nucleus basalis of Meynert (nbM) to the cerebral cortex. Neuropathological changes in both of these nuclei have been reported in Alzheimer's disease (AD). Although many morphometric studies of the nbM in AD have been documented, only one such study of the NRD has been documented, only one such study of the NRD has been conducted so far; it demonstrated a six fold increase in neurofibrillary tangles in AD but no statistically significant difference in the number of neurons in patients with AD and age‐matched controls. A study of the NRD utilizing different stains and wider anatomical boundaries is detailed in this report of 5 patients with AD and 7 age‐matched controls. In AD the NRD showed 39 times more neurofibrillary tangles and the number and cell density of large neurons were reduced to 23% and 28%, respectively, of those in the controls. A small number of senile plaques were found in the NRD in all patients with AD but none were found in the controls.
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Citations
Cites
Jones, E. G., Burton, H., Saper, C. B., & Swanson, L. W. (1976) · Journal of Comparative Neurology · doi:10.1002/cne.901670402 · Cited by 420
Alzheimer's Neurofibrillary Changes: A Topographic Study
HIRANO, A. (1962) · Archives of Neurology · doi:10.1001/archneur.1962.04210030065009 · Cited by 402
Self-citation
Cited by
A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat
Vertes, R. P. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130409 · Cited by 842
Katzman, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604103141506 · Cited by 801
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772
Uchida, Y., Takio, K., Titani, K., Ihara, Y., & Tomonaga, M. (1991) · Neuron · doi:10.1016/0896-6273(91)90272-2 · Cited by 699
Davies, C. A., Mann, D. M. A., Sumpter, P. Q., & Yates, P. O. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90057-8 · Cited by 628
Metadata
- Authors
- Yamamoto, T., & Hirano, A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1985-06
- Volume
- 17
- Issue
- 6
- Pages
- 573-577
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2023055592
- Cited by
- 338
- References
- 2
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yamamoto, T., & Hirano, A. (1985). Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons. Annals of Neurology. https://doi.org/10.1002/ana.410170608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
