The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The substantia nigra and ventral tegmental area in Alzheimer’s disease and Down’s syndrome
Open accessAbstract
Degenerative changes in the substantia nigra and ventral tegmental area were investigated in 104 cases of Alzheimer's disease and 13 cases of Down's syndrome. Frequencies of tangles in three groups of patients with Alzheimer's disease were 86%, 44% and 46% (54% overall) respectively. About half of those with tangles, but no Lewy bodies, had excess nigral cell loss, and 16% had moderate or severe neuronal fallout, but none had a Parkinsonian syndrome. Cases with nigral tangles were younger, tended to have more hippocampal and cortical tangles and plaques, and lower activities of cortical choline acetyltransferase. In most cases of Alzheimer's disease degeneration in nigral and tegmental areas was greater than controls, and tangles were evenly distributed. All the cases of Down's syndrome had tangles in the nigra and eight showed mild cell loss. Mild degenerative changes accompanied by tangles in the substantia nigra and ventral tegmental area are common in Alzheimer's disease, but severe cell loss is rare. When a Parkinsonian syndrome occurs in Alzheimer's disease it is likely to be due to Lewy body pathology.
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“multiple studies established an early link be tween AD and deficits in mesocorticolimbic DA signalling”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Gibb et al., 1989
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Metadata
- Authors
- Gibb, W. R., Mountjoy, C. Q., Mann, D. M., & Lees, A. J.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1989-02-01
- Volume
- 52
- Issue
- 2
- Pages
- 193-200
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1032505
- OpenAlex
- W2015429211
- Cited by
- 122
- References
- 43
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 4 · 2023: 14 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 1
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- substantia nigra, ventral tegmental area, Alzheimer's disease, Down syndrome, neurofibrillary tangles, Lewy bodies, parkinsonism, choline acetyltransferase
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Inclusion Bodies, Cerebral Cortex, Down Syndrome, Female, Hippocampus, Humans, Male, Melanins, Middle Aged, Nerve Degeneration, Neurofibrils, Neurons, Substantia Nigra, Tegmentum Mesencephali
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