The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The substantia nigra and ventral tegmental area in Alzheimer’s disease and Down’s syndrome
Open accessAbstract
Degenerative changes in the substantia nigra and ventral tegmental area were investigated in 104 cases of Alzheimer's disease and 13 cases of Down's syndrome. Frequencies of tangles in three groups of patients with Alzheimer's disease were 86%, 44% and 46% (54% overall) respectively. About half of those with tangles, but no Lewy bodies, had excess nigral cell loss, and 16% had moderate or severe neuronal fallout, but none had a Parkinsonian syndrome. Cases with nigral tangles were younger, tended to have more hippocampal and cortical tangles and plaques, and lower activities of cortical choline acetyltransferase. In most cases of Alzheimer's disease degeneration in nigral and tegmental areas was greater than controls, and tangles were evenly distributed. All the cases of Down's syndrome had tangles in the nigra and eight showed mild cell loss. Mild degenerative changes accompanied by tangles in the substantia nigra and ventral tegmental area are common in Alzheimer's disease, but severe cell loss is rare. When a Parkinsonian syndrome occurs in Alzheimer's disease it is likely to be due to Lewy body pathology.
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“multiple studies established an early link be tween AD and deficits in mesocorticolimbic DA signalling”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Gibb et al., 1989
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Citations
Cites
Progressive Supranuclear Palsy
Steele, J. C. (1964) · Archives of Neurology · doi:10.1001/archneur.1964.00460160003001 · Cited by 1,930
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159
Bondareff, W., Mountjoy, C. Q., & Roth, M. (1982) · Neurology · doi:10.1212/wnl.32.2.164 · Cited by 683
Self-citationA POST-MORTEM STUDY OF THE CHOLINERGIC AND GABA SYSTEMS IN SENILE DEMENTIA
Rossor, M. N., Garrett, N., Johnson, A. L., Mountjoy, C. Q., Roth, M., & Iversen, L. L. (1982) · Brain · doi:10.1093/brain/105.2.313 · Cited by 460
Self-citationCell loss in the locus coeruleus in senile dementia of Alzheimer type
Tomlinson, B. E., Irving, D., & Blessed, G. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90031-9 · Cited by 453
PARKINSONISM-DEMENTIA COMPLEX, AN ENDEMIC DISEASE ON THE ISLAND OF GUAM
Hirano, A., Kurland, L. T., Krooth, R. S., & Lessell, S. (1961) · Brain · doi:10.1093/brain/84.4.642 · Cited by 419
Alzheimer's disease in Down's syndrome: Clinicopathologic studies
Wisniewski, K. E., Dalton, A. J., McLachlan, D. R. C., Wen, G. Y., & Wisniewski, H. M. (1985) · Neurology · doi:10.1212/wnl.35.7.957 · Cited by 417
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1984) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1984.tb00351.x · Cited by 345
Self-citationBurger, P. C., & Vogel, F. S. (1973) · PubMed Central · Cited by 342
Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons
Yamamoto, T., & Hirano, A. (1985) · Annals of Neurology · doi:10.1002/ana.410170608 · Cited by 338
Aral, H., Kosaka, K., & Iizuka, R. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb00913.x · Cited by 310
Biochemical changes in Dementia disorders of Alzheimer type (AD/SDAT)
Gottfries, C., Adolfsson, R., Aquilonius, S., Carlsson, A., Eckernäs, S. ‐., Nordberg, A. K., Oreland, L., Svennerholm, L. T., Wiberg, Å., & Winblad, B. G. (1983) · Neurobiology of Aging · doi:10.1016/0197-4580(83)90002-7 · Cited by 303
Ishii, T. (1966) · Acta Neuropathologica · doi:10.1007/bf00686763 · Cited by 303
Cortical neuronal counts in normal elderly controls and demented patients
Mountjoy, C. Q., Roth, M., Evans, N. J. R., & Evans, H. M. (1983) · Neurobiology of Aging · doi:10.1016/0197-4580(83)90048-9 · Cited by 291
Self-citationPRESENILE DEMENTIA AND ALZHEIMER'S DISEASE IN MONGOLISM
Olson, M. I., & Shaw, C. (1969) · Brain · doi:10.1093/brain/92.1.147 · Cited by 290
Changes in the Monoamine Containing Neurones of the Human Cns in Senile Dementia
Mann, D. M. A., Lincoln, J., Yates, P. O., Stamp, J., & Toper, S. (1980) · The British Journal of Psychiatry · doi:10.1192/bjp.136.6.533 · Cited by 285
Self-citationYates, C. M., Simpson, J. A., Gordon, A., Maloney, A. F. J., Allison, Y., Ritchie, I. M., & Urquhart, A. L. (1983) · Brain Research · doi:10.1016/0006-8993(83)91179-4 · Cited by 251
PARKINSONISM-DEMENTIA COMPLEX, AN ENDEMIC DISEASE ON THE ISLAND OF GUAM
HIRANO, A., Malamud, N., & Kurland, L. T. (1961) · Brain · doi:10.1093/brain/84.4.662 · Cited by 247
Nucleus Raphe Dorsalis in Dementia of the Alzheimer Type
Curcio, C. A., & Kemper, T. L. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198407000-00001 · Cited by 225
Presenile dementia in Down's syndrome
Ellis, W. G., McCULLOCH, J. R., & CORLEY, C. L. (1974) · Neurology · doi:10.1212/wnl.24.2.101 · Cited by 221
Abnormalities of the nucleus basalis in Down's syndrome
Casanova, M. F., Walker, L. C., Whitehouse, P. J., & Price, D. L. (1985) · Annals of Neurology · doi:10.1002/ana.410180306 · Cited by 202
The noradrenergic system in Alzheimer and multi-infarct dementias.
Mann, D., Yates, P. O., & Hawkes, J. (1982) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.45.2.113 · Cited by 185
Self-citationThe pathology of the human locus ceruleus.
Mann, D. M. A., Yates, P. O., & Hawkes, J. (1983) · PubMed · Cited by 161
Self-citationALZHEIMER'S DISEASE AND RELATED DISORDERS
Raskind, M. A., & Peskind, E. R. (2001) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70341-2 · Cited by 161
Extrapyramidal signs in Alzheimer's disease
Mölsä, P. K., Marttila, R. J., & Rinne, U. K. (1984) · Neurology · doi:10.1212/wnl.34.8.1114 · Cited by 153
Monoamine metabolism in senile dementia of Alzheimer type
Cross, A. J., Crow, T. J., Johnson, J. A., Joseph, M. H., Perry, E. K., Perry, R. H., Blessed, G., & Tomlinson, B. E. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90149-1 · Cited by 150
Roth, M. (1986) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072097 · Cited by 149
RECENT ADVANCES IN NEUROPATHOLOGY
Perry, R. H. (1986) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072096 · Cited by 132
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90439-2 · Cited by 127
Self-citationAlzheimer's disease and senile dementia of Alzheimer type
Sulkava, R. O. (1982) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1982.tb03117.x · Cited by 125
The Extrapyramidal Disorder of Alzheimer’s Disease
Pearce, J. M. S. (2008) · European Neurology · doi:10.1159/000114608 · Cited by 114
Dm, M., Yates, P. O., & Marcyniuk, B. (1985) · PubMed · Cited by 100
PATHOLOGICAL EVIDENCE FOR NEUROTRANSMITTER DEFICITS IN DOWN'S SYNDROME OF MIDDLE AGE
Mann, D. M. A., Yates, P. O., Marcyniuk, B., & Ravindra, C. (1985) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1985.tb00320.x · Cited by 97
Self-citationDopaminergic neurotransmitter systems in Alzheimer's disease and in Down's syndrome at middle age.
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.3.341 · Cited by 97
Self-citationAlzheimer's Disease and Down's Syndrome*
Price, D. L., Whitehouse, P. J., Struble, R. G., Coyle, J. T., Clark, A. W., DeLong, M. R., Cork, L. C., & Hedreen, J. C. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb26850.x · Cited by 94
MENTAL ILLNESS AND THE AGEING BRAIN
Cumings, J. N. (1963) · Journal of Clinical Pathology · doi:10.1136/jcp.16.1.98-c · Cited by 93
Recent Advances in Parkinson's Disease.
MCDOWELL, F. H., & Markham, C. H. (1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-3-527_1 · Cited by 92
Rb, C. (1982) · PubMed · Cited by 74
Tabaton, M., Schenone, A. E., Romagnoli, P., & Mancardi, G. (1985) · Acta Neuropathologica · doi:10.1007/bf00690198 · Cited by 69
DOPAMINE IN ALZHEIMER'S DISEASE AND SENILE DEMENTIA
Yates, C., Allison, Y., Simpson, J., Maloney, A. F. J., & Gordon, A. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92202-5 · Cited by 62
EXTRAPYRAMIDAL DEMENTIA AND LEVODOPA
Drachman, D. A., & Stahl, S. M. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92479-4 · Cited by 49
The estimation of neuronal population density by a robust distance method
Aherne, W., & Diggle, P. J. (1978) · Journal of Microscopy · doi:10.1111/j.1365-2818.1978.tb00138.x · Cited by 31
Alzheimer's Disease and Related Disorders
Bigl, V. (1987) · Neurochemistry International · doi:10.1016/0197-0186(87)90089-1 · Cited by 23
Flagged first, then by citations
Cited by
Sorted by citations
Dopamine and the regulation of cognition and attention
Nieoullon, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00011-4 · Cited by 1,131
Pathology of Parkinson’s disease
Jellinger, K. A. (1991) · Molecular and Chemical Neuropathology · doi:10.1007/bf03159935 · Cited by 708
Nobili, A., Latagliata, E. C., Viscomi, M. T., Cavallucci, V., Cutuli, D., Giacovazzo, G., Krashia, P., Rizzo, F. R., Marino, R., Federici, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms14727 · Cited by 514
Dopaminergic reward system: a short integrative review
Arias-Carrión, Ó., Stamelou, M., Murillo‐Rodríguez, E., Menéndez‐González, M., & Pöppel, E. (2010) · International Archives of Medicine · doi:10.1186/1755-7682-3-24 · Cited by 478
Negative symptoms: the ‘pathology’ of motivation and goal-directed behaviour
Brown, R. G., & Pluck, G. C. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01626-x · Cited by 297
Metadata
- Authors
- Gibb, W. R., Mountjoy, C. Q., Mann, D. M., & Lees, A. J.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1989-02-01
- Volume
- 52
- Issue
- 2
- Pages
- 193-200
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1032505
- OpenAlex
- W2015429211
- Cited by
- 122
- References
- 43
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 4 · 2023: 14 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 1
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- substantia nigra, ventral tegmental area, Alzheimer's disease, Down syndrome, neurofibrillary tangles, Lewy bodies, parkinsonism, choline acetyltransferase
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Inclusion Bodies, Cerebral Cortex, Down Syndrome, Female, Hippocampus, Humans, Male, Melanins, Middle Aged, Nerve Degeneration, Neurofibrils, Neurons, Substantia Nigra, Tegmentum Mesencephali
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