Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's disease
Abstract
The quantitative relationship between the numbers of senile plaques and neurofibrillary tangles in the temporal cortex and the degree of atrophy and loss of nerve cells from this region and from cortically projecting areas such as the nucleus basalis of Meynert, locus coeruleus and raphe nucleus was investigated in 32 patients with Alzheimer's disease. Strong correlations were noted between cortical plaque and tangle counts and nerve cell atrophy and loss in all 4 areas, suggesting that the formation of plaques and tangles may be of primary pathogenic importance to the cortical and subcortical cell loss.
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Previous studies helped establish the connection between amyloid-beta plaques, neurofibrillary tangles, and antemortem cognitive impairment.
“and previous studies that had also helped to establish the connection between AβPs, NFTs, and antemortem cognitive impairment (311-320).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [311]
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- Authors
- Mann, D. M. A., Yates, P. O., & Marcyniuk, B.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Mann, David M.A.
- ORCID
- Mann, David M.A.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1985-05
- Volume
- 56
- Issue
- 1
- Pages
- 51-55
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2087908526
- Cited by
- 127
- References
- 23
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid plaques, neurofibrillary tangles, neuronal loss, neuronal atrophy, temporal cortex, nucleus basalis of Meynert, locus coeruleus, raphe nuclei, subcortical structures, neuropathology
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Brain, Humans, Neurofibrils, Raphe Nuclei, Substantia Innominata, Substantia Nigra, Temporal Lobe
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