Cited by 127Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's disease

Mann, David M.A., Yates, Peter O., Marcyniuk, Borys·1985·Neuroscience Letters

Abstract

The quantitative relationship between the numbers of senile plaques and neurofibrillary tangles in the temporal cortex and the degree of atrophy and loss of nerve cells from this region and from cortically projecting areas such as the nucleus basalis of Meynert, locus coeruleus and raphe nucleus was investigated in 32 patients with Alzheimer's disease. Strong correlations were noted between cortical plaque and tangle counts and nerve cell atrophy and loss in all 4 areas, suggesting that the formation of plaques and tangles may be of primary pathogenic importance to the cortical and subcortical cell loss.

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Crossref · 10.1016/0304-3940(85)90439-2

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Authors
Mann, D. M. A., Yates, P. O., & Marcyniuk, B.
Affiliations
University of Manchester (GB)
Corresponding author
Mann, David M.A.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
1985-05
Volume
56
Issue
1
Pages
51-55
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2087908526
Cited by
127
References
23
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
16.22
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, amyloid plaques, neurofibrillary tangles, neuronal loss, neuronal atrophy, temporal cortex, nucleus basalis of Meynert, locus coeruleus, raphe nuclei, subcortical structures, neuropathology
MeSH terms
Aged, Alzheimer Disease, Atrophy, Brain, Humans, Neurofibrils, Raphe Nuclei, Substantia Innominata, Substantia Nigra, Temporal Lobe

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