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Asbestos fibre dimensions and lung cancer mortality among workers exposed to chrysotile
Abstract
Objectives: To estimate exposures to asbestos fibres of specific sizes among asbestos textile manufacturing workers exposed to chrysotile using data from transmission electron microscopy (TEM) and to evaluate the extent to which the risk of lung cancer varies with fibre length and diameter. Methods: 3803 workers employed for at least 1 day between 1 January 1950 and 31 December 1973 in any of three plants in North Carolina, USA that produced asbestos textile products and followed for vital status through 31 December 2003 were included. Historical exposures to asbestos fibres were estimated from work histories and 3578 industrial hygiene measurements taken in 1935–1986. Exposure–response relationships for lung cancer were examined within the cohort using Poisson regression. Results: Indicators of fibre length and diameter obtained by TEM were positively and significantly associated with increasing risk of lung cancer. Exposures to longer and thinner fibres tended to be most strongly associated with lung cancer, and models for these fibres fit the data best. Simultaneously modelling indicators of cumulative mean fibre length and diameter yielded a positive coefficient for fibre length and a negative coefficient for fibre diameter. Conclusions: The results support the hypothesis that the risk of lung cancer among workers exposed to chrysotile asbestos increases with exposure to longer fibres. More research is needed to improve the characterisation of exposures by fibre size and number and to analyse the associated risks in a variety of industries and populations.
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“Nevertheless, the authors noted that exposure to short, thin fibers was associated with lung cancer risk, and these fibers represented the majority of those counted by TEM.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [34]
In the citing paper
“According to recent human data [33-37], it can be inferred that exposure to longer fibers was associated with higher rates of lung cancer, but no definite conclusion can be ascertained for the other size classes.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [34]
In the citing paper
“Cumulative exposure to all fibers counted by TEM was significantly associated with lung cancer risk, and to fibers of every length and diameter category when each dimension was considered separately.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [34]
In the citing paper
“Results from Loomis et al. [34] are consistent with those reported for South Carolina asbestos textile workers.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [34]
In the citing paper
“Models for exposure to longer fibers fit the data best and indicated the strongest association with lung cancer.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [34]
In the citing paper
“The model for TEM fibers > 5 μm of length fits the data better than models for other TEM exposure indicators of size classes.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [34]
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Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Case, B. W., Abraham, J. L., Meeker, G., Pooley, F. D., & Pinkerton, K. E. (2011) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2011.556045 · Cited by 123
Is asbestos still a problem in the world? A current review
Thives, L. P., Ghisi, E., Thives Júnior, J. J., & Vieira, A. S. (2022) · Journal of Environmental Management · doi:10.1016/j.jenvman.2022.115716 · Cited by 118
Korchevskiy, A., Rasmuson, J. O., & Rasmuson, E. J. (2019) · Inhalation Toxicology · doi:10.1080/08958378.2019.1640320 · Cited by 50
Asbestos in the ambient air from rural, urban, residential, baseball and mining areas in South Korea
Jung, H.-S., Jang, J., Cho, Y., Lee, J.-C., & Kim, H. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01226-7 · Cited by 8
Metadata
- Authors
- Loomis, D., Dement, J., Richardson, D., & Wolf, S.
- Venue
- Occupational and Environmental Medicine
- Publisher
- BMJ
- Published
- 2009-11-05
- Volume
- 67
- Issue
- 9
- Pages
- 580-584
- ISSN
- 1351-0711
- 1470-7926
- PMC
- PMC2975987
- Cited by
- 75
- References
- 0
- Language
- en
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- Loomis, D., Dement, J., Richardson, D., & Wolf, S. (2010). Asbestos fibre dimensions and lung cancer mortality among workers exposed to chrysotile. Occupational and Environmental Medicine. https://doi.org/10.1136/oem.2009.050120
